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Acute renal failure is associated with higher death and disability in patients with acute ischemic stroke: analysis of nationwide inpatient sample.
Stroke. 2014 May; 45(5):1478-80.S

Abstract

BACKGROUND AND PURPOSE

Acute renal failure (ARF) in setting of acute ischemic stroke (AIS) is associated with worse outcome. We sought to determine the prevalence of ARF and effect on outcomes of patients with AIS.

METHODS

Data from all patients admitted to US hospitals between 2002 and 2010 with a primary discharge diagnosis of ischemic stroke and secondary diagnosis of ARF were included. The effect of ARF on rates of intracerebral hemorrhage and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis.

RESULTS

Of 7,068,334 patients with AIS, 372,223 (5.3%) had ARF during hospitalization. Dialysis was required in 2364 (0.6%) of 372,223 patients. Patients with AIS with ARF had higher rates of moderate to severe disability (41.3% versus 30%; P<0.0001), intracerebral hemorrhage (1.0% versus 0.5%; P<0.0001), and in-hospital mortality (8.4% versus 2.9%; P<0.0001) compared with those without ARF. After adjusting for confounding factors, patients with AIS with ARF had higher odds of moderate to severe disability (odds ratio, 1.3; 95% confidence interval, 1.3-1.4; P<0.0001), intracerebral hemorrhage (odds ratio, 1.4; 95% confidence interval, 1.3-1.6; P<0.0001), and death (odds ratio, 2.2; 95% confidence interval, 2.0-2.2; P<0.0001).

CONCLUSIONS

ARF in patients with AIS is associated with significantly higher rates of moderate to severe disability at discharge and in-hospital mortality.

Authors+Show Affiliations

From the Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH (F.S.); Zeenat Qureshi Stroke Institute, St. Cloud, MN (M.M.A., A.I.Q.); Department of Neurology, Louisiana State University Health Science Center, New Orleans, LA (F.K., L.A.B.); Department of Medicine, University of Rochester Medical Center, Rochester, NY (U.A.D.); and Department of Neurology, Ochsner Clinic Foundation, New Orleans, LA (G.A.V.).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24619397

Citation

Saeed, Fahad, et al. "Acute Renal Failure Is Associated With Higher Death and Disability in Patients With Acute Ischemic Stroke: Analysis of Nationwide Inpatient Sample." Stroke, vol. 45, no. 5, 2014, pp. 1478-80.
Saeed F, Adil MM, Khursheed F, et al. Acute renal failure is associated with higher death and disability in patients with acute ischemic stroke: analysis of nationwide inpatient sample. Stroke. 2014;45(5):1478-80.
Saeed, F., Adil, M. M., Khursheed, F., Daimee, U. A., Branch, L. A., Vidal, G. A., & Qureshi, A. I. (2014). Acute renal failure is associated with higher death and disability in patients with acute ischemic stroke: analysis of nationwide inpatient sample. Stroke, 45(5), 1478-80. https://doi.org/10.1161/STROKEAHA.114.004672
Saeed F, et al. Acute Renal Failure Is Associated With Higher Death and Disability in Patients With Acute Ischemic Stroke: Analysis of Nationwide Inpatient Sample. Stroke. 2014;45(5):1478-80. PubMed PMID: 24619397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute renal failure is associated with higher death and disability in patients with acute ischemic stroke: analysis of nationwide inpatient sample. AU - Saeed,Fahad, AU - Adil,Malik M, AU - Khursheed,Faraz, AU - Daimee,Usama A, AU - Branch,Lionel A,Jr AU - Vidal,Gabriel A, AU - Qureshi,Adnan I, Y1 - 2014/03/11/ PY - 2014/3/13/entrez PY - 2014/3/13/pubmed PY - 2014/7/6/medline KW - acute ischemic stroke KW - acute renal failure SP - 1478 EP - 80 JF - Stroke JO - Stroke VL - 45 IS - 5 N2 - BACKGROUND AND PURPOSE: Acute renal failure (ARF) in setting of acute ischemic stroke (AIS) is associated with worse outcome. We sought to determine the prevalence of ARF and effect on outcomes of patients with AIS. METHODS: Data from all patients admitted to US hospitals between 2002 and 2010 with a primary discharge diagnosis of ischemic stroke and secondary diagnosis of ARF were included. The effect of ARF on rates of intracerebral hemorrhage and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis. RESULTS: Of 7,068,334 patients with AIS, 372,223 (5.3%) had ARF during hospitalization. Dialysis was required in 2364 (0.6%) of 372,223 patients. Patients with AIS with ARF had higher rates of moderate to severe disability (41.3% versus 30%; P<0.0001), intracerebral hemorrhage (1.0% versus 0.5%; P<0.0001), and in-hospital mortality (8.4% versus 2.9%; P<0.0001) compared with those without ARF. After adjusting for confounding factors, patients with AIS with ARF had higher odds of moderate to severe disability (odds ratio, 1.3; 95% confidence interval, 1.3-1.4; P<0.0001), intracerebral hemorrhage (odds ratio, 1.4; 95% confidence interval, 1.3-1.6; P<0.0001), and death (odds ratio, 2.2; 95% confidence interval, 2.0-2.2; P<0.0001). CONCLUSIONS: ARF in patients with AIS is associated with significantly higher rates of moderate to severe disability at discharge and in-hospital mortality. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/24619397/Acute_renal_failure_is_associated_with_higher_death_and_disability_in_patients_with_acute_ischemic_stroke:_analysis_of_nationwide_inpatient_sample_ L2 - https://www.ahajournals.org/doi/10.1161/STROKEAHA.114.004672?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -