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Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder.
Psychopharmacology (Berl) 2014; 231(8):1467-77P

Abstract

RATIONALE

The active component of cannabis, delta-9 tetrahydrocannabinol (THC), has a long half-life and widespread neurocognitive effects. There are inconsistent reports of neurocognitive deficits in adults and adolescents with cannabis use disorders (CUD), particularly after a period of abstinence.

OBJECTIVES

This study aims to examine neurocognitive measures (IQ, academic achievement, attention, memory, executive functions) in abstinent adolescents with CUD, while controlling for demographic, psychopathology, and poly-substance confounders.

METHODS

We investigated neurocognitive performance in three groups: adolescents with CUD after successful first treatment and in full remission (n = 33); controls with psychiatric disorders without substance use disorder history (n = 37); and healthy adolescents (n = 43).

RESULTS

Adolescents with psychiatric disorders, regardless of CUD status, performed significantly worse than the healthy adolescents in academic achievement. No group differences were seen in IQ, attention, memory, or executive functions. Lower academic achievement was positively associated with younger age of CUD onset, regular cannabis use, and maximum daily use. In the CUD group, lifetime nicotine use episodes were negatively associated with IQ. Lower overall neurocognitive function was associated with younger age of onset of regular cannabis use and relapse within the 1 year follow-up.

CONCLUSIONS

Verifiably, abstinent adolescents with CUD history did not differ from the two comparison groups, suggesting that previously reported neurocognitive deficits may be related to other factors, including residual drug effects, preexisting cognitive deficits, concurrent use of other substances (e.g., nicotine), or psychopathology. Adolescents with CUD may not be vulnerable to THC neuropsychological deficits once they achieve remission from all drugs for at least 30 days.

Authors+Show Affiliations

Department of Psychiatry and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24619597

Citation

Hooper, Stephen R., et al. "Intellectual, Neurocognitive, and Academic Achievement in Abstinent Adolescents With Cannabis Use Disorder." Psychopharmacology, vol. 231, no. 8, 2014, pp. 1467-77.
Hooper SR, Woolley D, De Bellis MD. Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder. Psychopharmacology (Berl). 2014;231(8):1467-77.
Hooper, S. R., Woolley, D., & De Bellis, M. D. (2014). Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder. Psychopharmacology, 231(8), pp. 1467-77. doi:10.1007/s00213-014-3463-z.
Hooper SR, Woolley D, De Bellis MD. Intellectual, Neurocognitive, and Academic Achievement in Abstinent Adolescents With Cannabis Use Disorder. Psychopharmacology (Berl). 2014;231(8):1467-77. PubMed PMID: 24619597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder. AU - Hooper,Stephen R, AU - Woolley,Donald, AU - De Bellis,Michael D, Y1 - 2014/03/12/ PY - 2013/05/17/received PY - 2014/01/21/accepted PY - 2014/3/13/entrez PY - 2014/3/13/pubmed PY - 2015/1/27/medline SP - 1467 EP - 77 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 231 IS - 8 N2 - RATIONALE: The active component of cannabis, delta-9 tetrahydrocannabinol (THC), has a long half-life and widespread neurocognitive effects. There are inconsistent reports of neurocognitive deficits in adults and adolescents with cannabis use disorders (CUD), particularly after a period of abstinence. OBJECTIVES: This study aims to examine neurocognitive measures (IQ, academic achievement, attention, memory, executive functions) in abstinent adolescents with CUD, while controlling for demographic, psychopathology, and poly-substance confounders. METHODS: We investigated neurocognitive performance in three groups: adolescents with CUD after successful first treatment and in full remission (n = 33); controls with psychiatric disorders without substance use disorder history (n = 37); and healthy adolescents (n = 43). RESULTS: Adolescents with psychiatric disorders, regardless of CUD status, performed significantly worse than the healthy adolescents in academic achievement. No group differences were seen in IQ, attention, memory, or executive functions. Lower academic achievement was positively associated with younger age of CUD onset, regular cannabis use, and maximum daily use. In the CUD group, lifetime nicotine use episodes were negatively associated with IQ. Lower overall neurocognitive function was associated with younger age of onset of regular cannabis use and relapse within the 1 year follow-up. CONCLUSIONS: Verifiably, abstinent adolescents with CUD history did not differ from the two comparison groups, suggesting that previously reported neurocognitive deficits may be related to other factors, including residual drug effects, preexisting cognitive deficits, concurrent use of other substances (e.g., nicotine), or psychopathology. Adolescents with CUD may not be vulnerable to THC neuropsychological deficits once they achieve remission from all drugs for at least 30 days. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/24619597/Intellectual_neurocognitive_and_academic_achievement_in_abstinent_adolescents_with_cannabis_use_disorder_ L2 - https://dx.doi.org/10.1007/s00213-014-3463-z DB - PRIME DP - Unbound Medicine ER -