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General and abdominal fat outcomes in school-age children associated with infant breastfeeding patterns.
Am J Clin Nutr. 2014 Jun; 99(6):1351-8.AJ

Abstract

BACKGROUND

Breastfeeding may have a protective effect on the development of obesity in later life. Not much is known about the effects of infant feeding on more-specific fat measures.

OBJECTIVE

We examined associations of breastfeeding duration and exclusiveness and age at the introduction of solid foods with general and abdominal fat outcomes in children.

DESIGN

We performed a population-based, prospective cohort study in 5063 children. Information about infant feeding was obtained by using questionnaires. At the median age of 6.0 y (95% range: 5.7 y, 6.8 y), we measured childhood anthropometric measures, total fat mass and the android:gynoid fat ratio by using dual-energy X-ray absorptiometry, and preperitoneal abdominal fat by using ultrasound.

RESULTS

We observed that, in the models adjusted for child age, sex, and height only, a shorter breastfeeding duration, nonexclusive breastfeeding, and younger age at the introduction of solid foods were associated with higher childhood general and abdominal fat measures (P-trend < 0.05) but not with higher childhood body mass index. The introduction of solid foods at a younger age but not breastfeeding duration or exclusivity was associated with higher risk of overweight or obesity (OR: 2.05; 95% CI: 1.41, 2.90). After adjustment for family-based sociodemographic, maternal lifestyle, and childhood factors, the introduction of solid food between 4 and 4.9 mo of age was associated with higher risks of overweight or obesity, but the overall trend was not significant.

CONCLUSIONS

Associations of infant breastfeeding and age at the introduction of solid foods with general and abdominal fat outcomes are explained by sociodemographic and lifestyle-related factors. Whether infant dietary composition affects specific fat outcomes at older ages should be further studied.

Authors+Show Affiliations

From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).From the Generation R Study Group (BD, DHMH, OG, RG, and VWVJ) and the Departments of Pediatrics (DHMH, OG, LD, RG, and VWVJ) and Epidemiology (BD, DHMH, OG, AH, LD, RG, and VWVJ), Erasmus University Medical Center, Rotterdam, Netherlands; the Department of Radiology, Radboud University, Nijmegen, Netherlands (RM); and Nutricia Research, Utrecht, Netherlands (MA-B and EMvdB).

Pub Type(s)

Comparative Study
Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24622802

Citation

Durmuş, Büşra, et al. "General and Abdominal Fat Outcomes in School-age Children Associated With Infant Breastfeeding Patterns." The American Journal of Clinical Nutrition, vol. 99, no. 6, 2014, pp. 1351-8.
Durmuş B, Heppe DH, Gishti O, et al. General and abdominal fat outcomes in school-age children associated with infant breastfeeding patterns. Am J Clin Nutr. 2014;99(6):1351-8.
Durmuş, B., Heppe, D. H., Gishti, O., Manniesing, R., Abrahamse-Berkeveld, M., van der Beek, E. M., Hofman, A., Duijts, L., Gaillard, R., & Jaddoe, V. W. (2014). General and abdominal fat outcomes in school-age children associated with infant breastfeeding patterns. The American Journal of Clinical Nutrition, 99(6), 1351-8. https://doi.org/10.3945/ajcn.113.075937
Durmuş B, et al. General and Abdominal Fat Outcomes in School-age Children Associated With Infant Breastfeeding Patterns. Am J Clin Nutr. 2014;99(6):1351-8. PubMed PMID: 24622802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - General and abdominal fat outcomes in school-age children associated with infant breastfeeding patterns. AU - Durmuş,Büşra, AU - Heppe,Denise H M, AU - Gishti,Olta, AU - Manniesing,Rashindra, AU - Abrahamse-Berkeveld,Marieke, AU - van der Beek,Eline M, AU - Hofman,Albert, AU - Duijts,Liesbeth, AU - Gaillard,Romy, AU - Jaddoe,Vincent W V, Y1 - 2014/03/12/ PY - 2014/3/14/entrez PY - 2014/3/14/pubmed PY - 2015/4/22/medline SP - 1351 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 99 IS - 6 N2 - BACKGROUND: Breastfeeding may have a protective effect on the development of obesity in later life. Not much is known about the effects of infant feeding on more-specific fat measures. OBJECTIVE: We examined associations of breastfeeding duration and exclusiveness and age at the introduction of solid foods with general and abdominal fat outcomes in children. DESIGN: We performed a population-based, prospective cohort study in 5063 children. Information about infant feeding was obtained by using questionnaires. At the median age of 6.0 y (95% range: 5.7 y, 6.8 y), we measured childhood anthropometric measures, total fat mass and the android:gynoid fat ratio by using dual-energy X-ray absorptiometry, and preperitoneal abdominal fat by using ultrasound. RESULTS: We observed that, in the models adjusted for child age, sex, and height only, a shorter breastfeeding duration, nonexclusive breastfeeding, and younger age at the introduction of solid foods were associated with higher childhood general and abdominal fat measures (P-trend < 0.05) but not with higher childhood body mass index. The introduction of solid foods at a younger age but not breastfeeding duration or exclusivity was associated with higher risk of overweight or obesity (OR: 2.05; 95% CI: 1.41, 2.90). After adjustment for family-based sociodemographic, maternal lifestyle, and childhood factors, the introduction of solid food between 4 and 4.9 mo of age was associated with higher risks of overweight or obesity, but the overall trend was not significant. CONCLUSIONS: Associations of infant breastfeeding and age at the introduction of solid foods with general and abdominal fat outcomes are explained by sociodemographic and lifestyle-related factors. Whether infant dietary composition affects specific fat outcomes at older ages should be further studied. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24622802/General_and_abdominal_fat_outcomes_in_school_age_children_associated_with_infant_breastfeeding_patterns_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.075937 DB - PRIME DP - Unbound Medicine ER -