Tags

Type your tag names separated by a space and hit enter

Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations.
Int J Cancer 2014; 135(8):1949-60IJ

Abstract

General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥ 30 kg/m(2) was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI <25 kg/m(2). Every 5 kg/m(2) increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% CI = 1.02-1.16) and all-cause death (HR = 1.11, 95% CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

Authors+Show Affiliations

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24623514

Citation

Fedirko, Veronika, et al. "Pre-diagnostic Anthropometry and Survival After Colorectal Cancer Diagnosis in Western European Populations." International Journal of Cancer, vol. 135, no. 8, 2014, pp. 1949-60.
Fedirko V, Romieu I, Aleksandrova K, et al. Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. Int J Cancer. 2014;135(8):1949-60.
Fedirko, V., Romieu, I., Aleksandrova, K., Pischon, T., Trichopoulos, D., Peeters, P. H., ... Jenab, M. (2014). Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. International Journal of Cancer, 135(8), pp. 1949-60. doi:10.1002/ijc.28841.
Fedirko V, et al. Pre-diagnostic Anthropometry and Survival After Colorectal Cancer Diagnosis in Western European Populations. Int J Cancer. 2014 Oct 15;135(8):1949-60. PubMed PMID: 24623514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. AU - Fedirko,Veronika, AU - Romieu,Isabelle, AU - Aleksandrova,Krasimira, AU - Pischon,Tobias, AU - Trichopoulos,Dimitrios, AU - Peeters,Petra H, AU - Romaguera-Bosch,Dora, AU - Bueno-de-Mesquita,H B As, AU - Dahm,Christina C, AU - Overvad,Kim, AU - Chirlaque,Maria-Dolores, AU - Johansen,Christoffer, AU - Bidstrup,Pernille E, AU - Dalton,Susanne O, AU - Gunter,Marc J, AU - Wark,Petra A, AU - Norat,Teresa, AU - Halkjaer,Jytte, AU - Tjønneland,Anne, AU - Dik,Vincent K, AU - Siersema,Peter D, AU - Boutron-Ruault,Marie-Christine, AU - Dossus,Laure, AU - Bastide,Nadia, AU - Kühn,Tilman, AU - Kaaks,Rudolf, AU - Boeing,Heiner, AU - Trichopoulou,Antonia, AU - Klinaki,Eleni, AU - Katsoulis,Michalis, AU - Pala,Valeria, AU - Panico,Salvatore, AU - Tumino,Rosario, AU - Palli,Domenico, AU - Vineis,Paolo, AU - Weiderpass,Elisabete, AU - Skeie,Guri, AU - González,Carlos A, AU - Sánchez,María-José, AU - Barricarte,Aurelio, AU - Amiano,Pilar, AU - Quiros,J Ramon, AU - Manjer,Jonas, AU - Jirström,Karin, AU - Ljuslinder,Ingrid, AU - Palmqvist,Richard, AU - Khaw,Kay-Tee, AU - Wareham,Nick, AU - Bradbury,Kathryn E, AU - Stepien,Magdalena, AU - Duarte-Salles,Talita, AU - Riboli,Elio, AU - Jenab,Mazda, Y1 - 2014/04/07/ PY - 2013/12/15/received PY - 2014/02/25/accepted PY - 2014/3/14/entrez PY - 2014/3/14/pubmed PY - 2014/9/30/medline KW - abdominal obesity KW - body composition KW - colorectal neoplasms KW - obesity KW - survival SP - 1949 EP - 60 JF - International journal of cancer JO - Int. J. Cancer VL - 135 IS - 8 N2 - General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥ 30 kg/m(2) was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI <25 kg/m(2). Every 5 kg/m(2) increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% CI = 1.02-1.16) and all-cause death (HR = 1.11, 95% CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/24623514/Pre_diagnostic_anthropometry_and_survival_after_colorectal_cancer_diagnosis_in_Western_European_populations_ L2 - https://doi.org/10.1002/ijc.28841 DB - PRIME DP - Unbound Medicine ER -