TY - JOUR T1 - In vitro Analysis of Antioxidant, Antimicrobial and Antiproliferative Activity of Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata Extracts. AU - Narasimhan,Manoj Kumar, AU - Pavithra,Shenoy K, AU - Krishnan,Vishnupriya, AU - Chandrasekaran,Muthukumaran, Y1 - 2013/11/02/ PY - 2013/03/21/received PY - 2013/06/12/accepted PY - 2014/3/14/entrez PY - 2014/3/14/pubmed PY - 2014/3/14/medline KW - Antioxidants KW - Reactive Oxygen Species KW - Seaweed SP - 151 EP - 9 JF - Jundishapur journal of natural pharmaceutical products JO - Jundishapur J Nat Pharm Prod VL - 8 IS - 4 N2 - BACKGROUND: Seaweeds are taxonomically diverse benthic algae, which are rich in bioactive compounds. These compounds have a potential application in medicine. OBJECTIVES: The aim of the study was to investigate the bioactive properties of three seaweed samples, Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata were collected from the shoreline of Mahabalipuram, Tamilnadu. MATERIALS AND METHODS: Bioactive components were extracted by using various solvents. Antioxidant analysis methods like scavenging activity of nitric oxide, hydrogen peroxide, hydroxyl radicals, free radical scavenging (DPPH), FRAP (ferric reducing ability plasma) ability and reducing power were carried out. MTT assay was employed to study the anticancer activity against cancer cell lines Hep-G2, MCF7 and normal VERO cell lines. RESULTS: It was found that methanolic extracts elicited higher total phenolic content, higher percentage scavenging activity of nitric oxide, hydrogen peroxide, hydroxyl radicals, free radical scavenging (DPPH), FRAP (ferric reducing ability plasma) ability and reducing power. Different concentrations of crude methanolic extracts of seaweeds showed potential antimicrobial activity by well diffusion method. Crude methanolic extract of G. corticata had significant anticancer activity followed by E. antenna and E. linza on cancer cell lines Hep-G2, MCF7 and normal VERO cell lines by MTT assay. CONCLUSIONS: The methanolic extracts of seaweeds Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata possess high total phenolic content and shows a good free radical scavenging activity and hence are proven to have better antioxidant activity and they might be good candidates for further investigations in order to develop potential anticancer drugs. SN - 1735-7780 UR - https://www.unboundmedicine.com/medline/citation/24624206/In_vitro_Analysis_of_Antioxidant_Antimicrobial_and_Antiproliferative_Activity_of_Enteromorpha_antenna_Enteromorpha_linza_and_Gracilaria_corticata_Extracts_ DB - PRIME DP - Unbound Medicine ER -