Tags

Type your tag names separated by a space and hit enter

Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial.
Eur J Prev Cardiol 2015; 22(5):582-93EJ

Abstract

BACKGROUND

Despite suffering from poor prognosis, progressive exercise intolerance, and impaired quality of life (QoL), effective therapeutic strategies in heart failure with preserved ejection fraction (HFpEF) are sparse. Exercise training (ET) improves physical QoL in HFpEF, but the effects on other aspects of QoL are unknown.

METHODS

The multicentre, prospective, randomized, controlled Exercise training in Diastolic Heart Failure Pilot study included 64 HFpEF patients (65 ± 7 years, 56% female). They were randomized to supervised endurance/resistance training in addition to usual care (ET, n = 44) or usual care alone (UC, n = 20). At baseline and after 3 months, QoL was assessed (36-item Short-form Health Survey (SF-36), Minnesota Living With Heart Failure Questionnaire (MLWHFQ), and Patient Health Questionnaire (PHQ-9).

RESULTS

Exercise improved the following SF-36 dimensions: physical functioning (p < 0.001, p = 0.001 vs. UC), bodily pain (p = 0.046), general health perception (p < 0.001, p = 0.016 vs. UC), general mental health (p = 0.002), vitality (p = 0.003), social functioning (p < 0.001) physical (p < 0.001, p = 0.001 vs. UC), and mental component score (p = 0.030). ET did not improve role limitations due to physical and emotional problems. The MLWHFQ total scale (p < 0.001) and the MLWHFQ physical limitation scale (p < 0.001, p = 0.04 vs. UC) also improved with ET. The MLWHFQ emotional limitation scale did not change with ET. With ET, also the PHQ-9 total score improved significantly (p = 0.004, p = 0.735 vs. UC).

CONCLUSIONS

In patients with HFpEF, exercise training improved emotional status, physical and social dimensions of QoL as well as symptoms of depression from pre to post test. Physical dimensions of QoL and general health perception also improved significantly with exercise in comparison to usual care.

Authors+Show Affiliations

Department of Cardiology, University of Göttingen, Göttingen, Germany.Department of Psychosomatic Medicine, University of Göttingen, Göttingen, Germany German Center for Cardiovascular Research (DZHK) Site Göttingen, Germany.Department of Cardiology, University of Göttingen, Göttingen, Germany German Center for Cardiovascular Research (DZHK) Site Göttingen, Germany.Institute for Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.Department of Internal Medicine - Cardiology, Charité - Campus Virchow-Klinikum, University of Berlin, Augustenburger Platz 1, Berlin, Germany.Department of Internal Medicine - Cardiology, Klinikum rechts der Isar, Technische Universität München, München, Germany.Department of Cardiology, University of Göttingen, Göttingen, Germany.Department of Cardiology, University of Göttingen, Göttingen, Germany Department of Psychosomatic Medicine, University of Göttingen, Göttingen, Germany.Department of Prevention, Rehabilitation and Sports Medicine, Technische Universität München, Munich, Germany.Department of Cardiology, University of Göttingen, Göttingen, Germany German Center for Cardiovascular Research (DZHK) Site Göttingen, Germany.Department of Prevention, Rehabilitation and Sports Medicine, Technische Universität München, Munich, Germany Munich Heart Alliance, Partner Site German Centre for Cardiovascular Research (DZHK), Germany.Department of Cardiology, Medical University of Graz, Graz, Austria.Department of Cardiology, University of Göttingen, Göttingen, Germany German Center for Cardiovascular Research (DZHK) Site Göttingen, Germany fedelmann@med.uni-goettingen.de.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

24627449

Citation

Nolte, Kathleen, et al. "Effects of Exercise Training On Different Quality of Life Dimensions in Heart Failure With Preserved Ejection Fraction: the Ex-DHF-P Trial." European Journal of Preventive Cardiology, vol. 22, no. 5, 2015, pp. 582-93.
Nolte K, Herrmann-Lingen C, Wachter R, et al. Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial. Eur J Prev Cardiol. 2015;22(5):582-93.
Nolte, K., Herrmann-Lingen, C., Wachter, R., Gelbrich, G., Düngen, H. D., Duvinage, A., ... Edelmann, F. (2015). Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial. European Journal of Preventive Cardiology, 22(5), pp. 582-93. doi:10.1177/2047487314526071.
Nolte K, et al. Effects of Exercise Training On Different Quality of Life Dimensions in Heart Failure With Preserved Ejection Fraction: the Ex-DHF-P Trial. Eur J Prev Cardiol. 2015;22(5):582-93. PubMed PMID: 24627449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial. AU - Nolte,Kathleen, AU - Herrmann-Lingen,Christoph, AU - Wachter,Rolf, AU - Gelbrich,Götz, AU - Düngen,Hans-Dirk, AU - Duvinage,André, AU - Hoischen,Nadine, AU - von Oehsen,Karima, AU - Schwarz,Silja, AU - Hasenfuss,Gerd, AU - Halle,Martin, AU - Pieske,Burkert, AU - Edelmann,Frank, Y1 - 2014/03/13/ PY - 2013/10/22/received PY - 2014/02/08/accepted PY - 2014/3/15/entrez PY - 2014/3/15/pubmed PY - 2016/2/18/medline KW - Depression KW - diastolic heart failure KW - exercise training KW - heart failure with preserved ejection fraction KW - quality of life SP - 582 EP - 93 JF - European journal of preventive cardiology JO - Eur J Prev Cardiol VL - 22 IS - 5 N2 - BACKGROUND: Despite suffering from poor prognosis, progressive exercise intolerance, and impaired quality of life (QoL), effective therapeutic strategies in heart failure with preserved ejection fraction (HFpEF) are sparse. Exercise training (ET) improves physical QoL in HFpEF, but the effects on other aspects of QoL are unknown. METHODS: The multicentre, prospective, randomized, controlled Exercise training in Diastolic Heart Failure Pilot study included 64 HFpEF patients (65 ± 7 years, 56% female). They were randomized to supervised endurance/resistance training in addition to usual care (ET, n = 44) or usual care alone (UC, n = 20). At baseline and after 3 months, QoL was assessed (36-item Short-form Health Survey (SF-36), Minnesota Living With Heart Failure Questionnaire (MLWHFQ), and Patient Health Questionnaire (PHQ-9). RESULTS: Exercise improved the following SF-36 dimensions: physical functioning (p < 0.001, p = 0.001 vs. UC), bodily pain (p = 0.046), general health perception (p < 0.001, p = 0.016 vs. UC), general mental health (p = 0.002), vitality (p = 0.003), social functioning (p < 0.001) physical (p < 0.001, p = 0.001 vs. UC), and mental component score (p = 0.030). ET did not improve role limitations due to physical and emotional problems. The MLWHFQ total scale (p < 0.001) and the MLWHFQ physical limitation scale (p < 0.001, p = 0.04 vs. UC) also improved with ET. The MLWHFQ emotional limitation scale did not change with ET. With ET, also the PHQ-9 total score improved significantly (p = 0.004, p = 0.735 vs. UC). CONCLUSIONS: In patients with HFpEF, exercise training improved emotional status, physical and social dimensions of QoL as well as symptoms of depression from pre to post test. Physical dimensions of QoL and general health perception also improved significantly with exercise in comparison to usual care. SN - 2047-4881 UR - https://www.unboundmedicine.com/medline/citation/24627449/Effects_of_exercise_training_on_different_quality_of_life_dimensions_in_heart_failure_with_preserved_ejection_fraction:_the_Ex_DHF_P_trial_ L2 - http://journals.sagepub.com/doi/full/10.1177/2047487314526071?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -