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Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells.
Thorax. 1988 Oct; 43(10):756-61.T

Abstract

Sodium cromoglycate and nedocromil sodium produced a dose dependent inhibition of histamine secretion from human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of lung parenchyma. Both compounds were significantly more active against the lavage cells than against the dispersed lung cells, and nedocromil sodium was an order of magnitude more effective than sodium cromoglycate against both cell types. Tachyphylaxis was observed with the parenchymal cells but not with the lavage cells. Nedocromil sodium and sodium cromoglycate also inhibited histamine release from the lavage cells of patients with sarcoidosis and extrinsic asthma.

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Authors+Show Affiliations

Leung KB
Department of Chemistry, University College London.
Flint KC
No affiliation info available
Brostoff J
No affiliation info available
Hudspith BN
No affiliation info available
Johnson NM
No affiliation info available
Lau HY
No affiliation info available
Liu WL
No affiliation info available
Pearce FL
No affiliation info available

MeSH

AsthmaBronchoalveolar Lavage FluidCromolyn SodiumDepression, ChemicalDose-Response Relationship, DrugHistamine ReleaseHumansLungLung DiseasesMast CellsNedocromilQuinolonesSarcoidosisTachyphylaxis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2462755

Citation

Leung, K B., et al. "Effects of Sodium Cromoglycate and Nedocromil Sodium On Histamine Secretion From Human Lung Mast Cells." Thorax, vol. 43, no. 10, 1988, pp. 756-61.
Leung KB, Flint KC, Brostoff J, et al. Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. Thorax. 1988;43(10):756-61.
Leung, K. B., Flint, K. C., Brostoff, J., Hudspith, B. N., Johnson, N. M., Lau, H. Y., Liu, W. L., & Pearce, F. L. (1988). Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. Thorax, 43(10), 756-61.
Leung KB, et al. Effects of Sodium Cromoglycate and Nedocromil Sodium On Histamine Secretion From Human Lung Mast Cells. Thorax. 1988;43(10):756-61. PubMed PMID: 2462755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. AU - Leung,K B, AU - Flint,K C, AU - Brostoff,J, AU - Hudspith,B N, AU - Johnson,N M, AU - Lau,H Y, AU - Liu,W L, AU - Pearce,F L, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 756 EP - 61 JF - Thorax JO - Thorax VL - 43 IS - 10 N2 - Sodium cromoglycate and nedocromil sodium produced a dose dependent inhibition of histamine secretion from human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of lung parenchyma. Both compounds were significantly more active against the lavage cells than against the dispersed lung cells, and nedocromil sodium was an order of magnitude more effective than sodium cromoglycate against both cell types. Tachyphylaxis was observed with the parenchymal cells but not with the lavage cells. Nedocromil sodium and sodium cromoglycate also inhibited histamine release from the lavage cells of patients with sarcoidosis and extrinsic asthma. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/2462755/Effects_of_sodium_cromoglycate_and_nedocromil_sodium_on_histamine_secretion_from_human_lung_mast_cells_ DB - PRIME DP - Unbound Medicine ER -