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Unraveling the ties between irritable bowel syndrome and intestinal microbiota.
World J Gastroenterol. 2014 Mar 14; 20(10):2470-81.WJ

Abstract

Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder. It is a multifactorial disorder. Intestinal microbiota may cause the pathogenesis of IBS by contributing to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, communication in the gut-brain axis, and so on. Previous attempts to identify the intestinal microbiota composition in IBS patients have yielded inconsistent and occasionally contradictory results. This inconsistency may be due to the differences in the molecular techniques employed, the sample collection and handling methods, use of single samples that are not linked to fluctuating symptoms, or other factors such as patients' diets and phenotypic characterizations. Despite these difficulties, previous studies found that the intestinal microbiota in some IBS patients was completely different from that in healthy controls, and there does appear to be a consistent theme of Firmicutes enrichment and reduced abundance of Bacteroides. Based on the differences in intestinal microbiota composition, many studies have addressed the roles of microbiota-targeted treatments, such as antibiotics and probiotics, in alleviating certain symptoms of IBS. This review summarizes the current knowledge of the associations between intestinal microbiota and IBS as well as the possible modes of action of intestinal microbiota in the pathogenesis of IBS. Improving the current level of understanding of host-microbiota interactions in IBS is important not only for determining the role of intestinal microbiota in IBS pathogenesis but also for therapeutic modulation of the microbiota.

Authors+Show Affiliations

Sung Noh Hong, Poong-Lyul Rhee, Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.Sung Noh Hong, Poong-Lyul Rhee, Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24627584

Citation

Hong, Sung Noh, and Poong-Lyul Rhee. "Unraveling the Ties Between Irritable Bowel Syndrome and Intestinal Microbiota." World Journal of Gastroenterology, vol. 20, no. 10, 2014, pp. 2470-81.
Hong SN, Rhee PL. Unraveling the ties between irritable bowel syndrome and intestinal microbiota. World J Gastroenterol. 2014;20(10):2470-81.
Hong, S. N., & Rhee, P. L. (2014). Unraveling the ties between irritable bowel syndrome and intestinal microbiota. World Journal of Gastroenterology, 20(10), 2470-81. https://doi.org/10.3748/wjg.v20.i10.2470
Hong SN, Rhee PL. Unraveling the Ties Between Irritable Bowel Syndrome and Intestinal Microbiota. World J Gastroenterol. 2014 Mar 14;20(10):2470-81. PubMed PMID: 24627584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unraveling the ties between irritable bowel syndrome and intestinal microbiota. AU - Hong,Sung Noh, AU - Rhee,Poong-Lyul, PY - 2013/10/02/received PY - 2013/11/26/revised PY - 2014/01/03/accepted PY - 2014/3/15/entrez PY - 2014/3/15/pubmed PY - 2015/4/7/medline KW - Antibiotics KW - Dysbiosis KW - Intestinal microbiota KW - Irritable bowel syndrome KW - Probiotics SP - 2470 EP - 81 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 20 IS - 10 N2 - Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorder. It is a multifactorial disorder. Intestinal microbiota may cause the pathogenesis of IBS by contributing to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, communication in the gut-brain axis, and so on. Previous attempts to identify the intestinal microbiota composition in IBS patients have yielded inconsistent and occasionally contradictory results. This inconsistency may be due to the differences in the molecular techniques employed, the sample collection and handling methods, use of single samples that are not linked to fluctuating symptoms, or other factors such as patients' diets and phenotypic characterizations. Despite these difficulties, previous studies found that the intestinal microbiota in some IBS patients was completely different from that in healthy controls, and there does appear to be a consistent theme of Firmicutes enrichment and reduced abundance of Bacteroides. Based on the differences in intestinal microbiota composition, many studies have addressed the roles of microbiota-targeted treatments, such as antibiotics and probiotics, in alleviating certain symptoms of IBS. This review summarizes the current knowledge of the associations between intestinal microbiota and IBS as well as the possible modes of action of intestinal microbiota in the pathogenesis of IBS. Improving the current level of understanding of host-microbiota interactions in IBS is important not only for determining the role of intestinal microbiota in IBS pathogenesis but also for therapeutic modulation of the microbiota. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24627584/Unraveling_the_ties_between_irritable_bowel_syndrome_and_intestinal_microbiota_ L2 - https://www.wjgnet.com/1007-9327/full/v20/i10/2470.htm DB - PRIME DP - Unbound Medicine ER -