Tags

Type your tag names separated by a space and hit enter

A review of metal-catalyzed molecular damage: protection by melatonin.
J Pineal Res. 2014 May; 56(4):343-70.JP

Abstract

Metal exposure is associated with several toxic effects; herein, we review the toxicity mechanisms of cadmium, mercury, arsenic, lead, aluminum, chromium, iron, copper, nickel, cobalt, vanadium, and molybdenum as these processes relate to free radical generation. Free radicals can be generated in cells due to a wide variety of exogenous and endogenous processes, causing modifications in DNA bases, enhancing lipid peroxidation, and altering calcium and sulfhydryl homeostasis. Melatonin, an ubiquitous and pleiotropic molecule, exerts efficient protection against oxidative stress and ameliorates oxidative/nitrosative damage by a variety of mechanisms. Also, melatonin has a chelating property which may contribute in reducing metal-induced toxicity as we postulate here. The aim of this review was to highlight the protective role of melatonin in counteracting metal-induced free radical generation. Understanding the physicochemical insights of melatonin related to the free radical scavenging activity and the stimulation of antioxidative enzymes is of critical importance for the development of novel therapeutic strategies against the toxic action of these metals.

Authors+Show Affiliations

Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24628077

Citation

Romero, Alejandro, et al. "A Review of Metal-catalyzed Molecular Damage: Protection By Melatonin." Journal of Pineal Research, vol. 56, no. 4, 2014, pp. 343-70.
Romero A, Ramos E, de Los Ríos C, et al. A review of metal-catalyzed molecular damage: protection by melatonin. J Pineal Res. 2014;56(4):343-70.
Romero, A., Ramos, E., de Los Ríos, C., Egea, J., Del Pino, J., & Reiter, R. J. (2014). A review of metal-catalyzed molecular damage: protection by melatonin. Journal of Pineal Research, 56(4), 343-70. https://doi.org/10.1111/jpi.12132
Romero A, et al. A Review of Metal-catalyzed Molecular Damage: Protection By Melatonin. J Pineal Res. 2014;56(4):343-70. PubMed PMID: 24628077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of metal-catalyzed molecular damage: protection by melatonin. AU - Romero,Alejandro, AU - Ramos,Eva, AU - de Los Ríos,Cristóbal, AU - Egea,Javier, AU - Del Pino,Javier, AU - Reiter,Russel J, Y1 - 2014/04/05/ PY - 2014/02/17/received PY - 2014/03/11/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/12/15/medline KW - chelating properties KW - free radicals KW - melatonin KW - metals KW - oxidative stress SP - 343 EP - 70 JF - Journal of pineal research JO - J Pineal Res VL - 56 IS - 4 N2 - Metal exposure is associated with several toxic effects; herein, we review the toxicity mechanisms of cadmium, mercury, arsenic, lead, aluminum, chromium, iron, copper, nickel, cobalt, vanadium, and molybdenum as these processes relate to free radical generation. Free radicals can be generated in cells due to a wide variety of exogenous and endogenous processes, causing modifications in DNA bases, enhancing lipid peroxidation, and altering calcium and sulfhydryl homeostasis. Melatonin, an ubiquitous and pleiotropic molecule, exerts efficient protection against oxidative stress and ameliorates oxidative/nitrosative damage by a variety of mechanisms. Also, melatonin has a chelating property which may contribute in reducing metal-induced toxicity as we postulate here. The aim of this review was to highlight the protective role of melatonin in counteracting metal-induced free radical generation. Understanding the physicochemical insights of melatonin related to the free radical scavenging activity and the stimulation of antioxidative enzymes is of critical importance for the development of novel therapeutic strategies against the toxic action of these metals. SN - 1600-079X UR - https://www.unboundmedicine.com/medline/citation/24628077/A_review_of_metal_catalyzed_molecular_damage:_protection_by_melatonin_ L2 - https://doi.org/10.1111/jpi.12132 DB - PRIME DP - Unbound Medicine ER -