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High-risk human papillomavirus and lymph node size in patients with single node metastasis of oral and oropharyngeal cancer.
Acta Otolaryngol 2014; 134(4):395-400AO

Abstract

CONCLUSION

High-risk human papillomavirus (HPV) infection was significantly related to lymph node size in patients with single node metastasis of oral and oropharyngeal cancer.

OBJECTIVE

The purpose of this study was to examine the relationship between high-risk HPV infection and lymph node size in patients with single node metastasis of oral and oropharyngeal carcinoma.

METHODS

This study included 48 patients with oral and oropharyngeal carcinoma. Pathologic lymph node stages comprised 36 N1 and 12 N2a.

RESULTS

High-risk HPV in situ hybridization was positive in 29% of patients (14/48). Of those patients with high-risk HPV, there was a significant difference (p = 0.008) between oral (9.5%) and oropharyngeal (44.4%) cancers. Average lymph node diameter was 20.7 ± 12.6 mm (range 5-54 mm). We found a positive correlation between high-risk HPV status and lymph node size (p = 0.018). Mean lymph node diameter in high-risk HPV-positive cases was 27.3 ± 13.1 mm and 18.0 ± 11.5 mm in high-risk HPV-negative cases. Extracapsular spread (p = 0.030) and cystic nodal metastases (p = 0.019) were also significantly related to lymph node size. High-risk HPV negative status (p = 0.043), advanced tumor stage (p = 0.009), and extracapsular spread (p = 0.038) all had significant adverse effects on 5-year disease-specific survival.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Korea , Seoul , Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24628336

Citation

Joo, Young-Hoon, et al. "High-risk Human Papillomavirus and Lymph Node Size in Patients With Single Node Metastasis of Oral and Oropharyngeal Cancer." Acta Oto-laryngologica, vol. 134, no. 4, 2014, pp. 395-400.
Joo YH, Cho KJ, Park JO, et al. High-risk human papillomavirus and lymph node size in patients with single node metastasis of oral and oropharyngeal cancer. Acta Otolaryngol. 2014;134(4):395-400.
Joo, Y. H., Cho, K. J., Park, J. O., Nam, I. C., Kim, C. S., & Kim, M. S. (2014). High-risk human papillomavirus and lymph node size in patients with single node metastasis of oral and oropharyngeal cancer. Acta Oto-laryngologica, 134(4), pp. 395-400. doi:10.3109/00016489.2013.844364.
Joo YH, et al. High-risk Human Papillomavirus and Lymph Node Size in Patients With Single Node Metastasis of Oral and Oropharyngeal Cancer. Acta Otolaryngol. 2014;134(4):395-400. PubMed PMID: 24628336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-risk human papillomavirus and lymph node size in patients with single node metastasis of oral and oropharyngeal cancer. AU - Joo,Young-Hoon, AU - Cho,Kwang-Jae, AU - Park,Jun-Ook, AU - Nam,In-Chul, AU - Kim,Chung-Soo, AU - Kim,Min-Sik, PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/11/19/medline SP - 395 EP - 400 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 134 IS - 4 N2 - CONCLUSION: High-risk human papillomavirus (HPV) infection was significantly related to lymph node size in patients with single node metastasis of oral and oropharyngeal cancer. OBJECTIVE: The purpose of this study was to examine the relationship between high-risk HPV infection and lymph node size in patients with single node metastasis of oral and oropharyngeal carcinoma. METHODS: This study included 48 patients with oral and oropharyngeal carcinoma. Pathologic lymph node stages comprised 36 N1 and 12 N2a. RESULTS: High-risk HPV in situ hybridization was positive in 29% of patients (14/48). Of those patients with high-risk HPV, there was a significant difference (p = 0.008) between oral (9.5%) and oropharyngeal (44.4%) cancers. Average lymph node diameter was 20.7 ± 12.6 mm (range 5-54 mm). We found a positive correlation between high-risk HPV status and lymph node size (p = 0.018). Mean lymph node diameter in high-risk HPV-positive cases was 27.3 ± 13.1 mm and 18.0 ± 11.5 mm in high-risk HPV-negative cases. Extracapsular spread (p = 0.030) and cystic nodal metastases (p = 0.019) were also significantly related to lymph node size. High-risk HPV negative status (p = 0.043), advanced tumor stage (p = 0.009), and extracapsular spread (p = 0.038) all had significant adverse effects on 5-year disease-specific survival. SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/24628336/High_risk_human_papillomavirus_and_lymph_node_size_in_patients_with_single_node_metastasis_of_oral_and_oropharyngeal_cancer_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016489.2013.844364 DB - PRIME DP - Unbound Medicine ER -