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The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial.
Clin Endocrinol (Oxf). 2014 Oct; 81(4):582-7.CE

Abstract

OBJECTIVE

This study was conducted to determine the effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress among women with polycystic ovary syndrome (PCOS).

DESIGN, PATIENTS AND MEASUREMENTS

This randomized, double-blind, placebo-controlled clinical trial was conducted among 69 women diagnosed with PCOS and aged 18-40 year old. Participants were randomly assigned to three groups receiving the following: (1) folate-1: 1 mg/d folate supplements (N = 23); (2) folate-5: 5 mg/d folate supplements (N = 23) and (3) placebo (N = 23) for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8 weeks to measure homocysteine (Hcy), inflammatory factors including high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), biomarkers of oxidative stress including total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA) and homoeostatic model assessment-beta cell function (HOMA-B).

RESULTS

Supplementation with 5 mg/d folate resulted in reduced plasma Hcy (-2·23 vs -1·86 and 1·16 μm, respectively, P < 0·05), HOMA-B (-7·63 vs 1·43 and 13·66, respectively, P < 0·05), serum hs-CRP (-212·2 vs -262·4 and 729·8 μg/l, respectively, P < 0·05) and plasma MDA concentrations (-0·48 vs -0·24 and 0·69 μm, respectively, P < 0·01) compared with folate-1 and placebo groups. Furthermore, a significant rise in plasma TAC (0·64 vs -3·53 and -215·47 mm, respectively, P < 0·01) and GSH levels (162·1 vs 195·8 and -158·2 μm, respectively, P < 0·01) was also observed following the administration of 5 mg/d folate supplements compared with folate-1 and placebo groups.

CONCLUSIONS

In conclusion, folate supplementation (5 mg/d) in women with PCOS had beneficial effects on inflammatory factors and biomarkers of oxidative stress.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Bahmani F
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Karamali M
No affiliation info available
Shakeri H
No affiliation info available
Asemi Z
No affiliation info available

MeSH

AdolescentAdultAntioxidantsBiomarkersC-Reactive ProteinDouble-Blind MethodFemaleFolic AcidGlutathioneHumansMalondialdehydeNitric OxideObesityOverweightOxidative StressPolycystic Ovary SyndromeYoung Adult

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24628390

Citation

Bahmani, Fereshteh, et al. "The Effects of Folate Supplementation On Inflammatory Factors and Biomarkers of Oxidative Stress in Overweight and Obese Women With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Clinical Trial." Clinical Endocrinology, vol. 81, no. 4, 2014, pp. 582-7.
Bahmani F, Karamali M, Shakeri H, et al. The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial. Clin Endocrinol (Oxf). 2014;81(4):582-7.
Bahmani, F., Karamali, M., Shakeri, H., & Asemi, Z. (2014). The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial. Clinical Endocrinology, 81(4), 582-7. https://doi.org/10.1111/cen.12451
Bahmani F, et al. The Effects of Folate Supplementation On Inflammatory Factors and Biomarkers of Oxidative Stress in Overweight and Obese Women With Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Clinical Trial. Clin Endocrinol (Oxf). 2014;81(4):582-7. PubMed PMID: 24628390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial. AU - Bahmani,Fereshteh, AU - Karamali,Maryam, AU - Shakeri,Hossein, AU - Asemi,Zatollah, Y1 - 2014/04/15/ PY - 2014/01/07/received PY - 2014/02/05/revised PY - 2014/02/06/revised PY - 2014/03/11/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2015/5/16/medline SP - 582 EP - 7 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 81 IS - 4 N2 - OBJECTIVE: This study was conducted to determine the effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress among women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS: This randomized, double-blind, placebo-controlled clinical trial was conducted among 69 women diagnosed with PCOS and aged 18-40 year old. Participants were randomly assigned to three groups receiving the following: (1) folate-1: 1 mg/d folate supplements (N = 23); (2) folate-5: 5 mg/d folate supplements (N = 23) and (3) placebo (N = 23) for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8 weeks to measure homocysteine (Hcy), inflammatory factors including high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), biomarkers of oxidative stress including total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA) and homoeostatic model assessment-beta cell function (HOMA-B). RESULTS: Supplementation with 5 mg/d folate resulted in reduced plasma Hcy (-2·23 vs -1·86 and 1·16 μm, respectively, P < 0·05), HOMA-B (-7·63 vs 1·43 and 13·66, respectively, P < 0·05), serum hs-CRP (-212·2 vs -262·4 and 729·8 μg/l, respectively, P < 0·05) and plasma MDA concentrations (-0·48 vs -0·24 and 0·69 μm, respectively, P < 0·01) compared with folate-1 and placebo groups. Furthermore, a significant rise in plasma TAC (0·64 vs -3·53 and -215·47 mm, respectively, P < 0·01) and GSH levels (162·1 vs 195·8 and -158·2 μm, respectively, P < 0·01) was also observed following the administration of 5 mg/d folate supplements compared with folate-1 and placebo groups. CONCLUSIONS: In conclusion, folate supplementation (5 mg/d) in women with PCOS had beneficial effects on inflammatory factors and biomarkers of oxidative stress. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/24628390/The_effects_of_folate_supplementation_on_inflammatory_factors_and_biomarkers_of_oxidative_stress_in_overweight_and_obese_women_with_polycystic_ovary_syndrome:_a_randomized_double_blind_placebo_controlled_clinical_trial_ DB - PRIME DP - Unbound Medicine ER -