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Beta-blockers increase the risk of being born small for gestational age or of being institutionalised during infancy.
BJOG. 2014 Aug; 121(9):1090-6.BJOG

Abstract

OBJECTIVE

To compare infant outcomes between mothers with hypertension treated by beta-blockers alone and by methyldopa alone during pregnancy.

DESIGN

Historical cohort study.

SETTING

Saskatchewan, Canada.

POPULATION

Women who delivered a singleton birth in Saskatchewan during the periods from 1 January 1980 to 30 June 1987 or from 1 January 1990 to 31 December 2005 (women who delivered between 1 July 1987 and 31 December 1989 were excluded because the information recorded on maternal drug use during pregnancy is incomplete) with a diagnosis of a hypertensive disorder during pregnancy, and who were dispensed only beta-blockers (n = 416) or only methyldopa (n = 1000).

METHODS

Occurrences of adverse infant outcomes were compared between women who received beta-blockers only and women who received methyldopa only during pregnancy, first in all eligible women, and then in women with chronic hypertension and in women with gestational hypertension or pre-eclampsia/eclampsia, separately. Multiple logistic regression analyses were performed to adjust for potential confounding.

MAIN OUTCOME MEASURES

Small for gestational age (SGA) < 10th percentile, SGA < 3rd percentile, preterm birth, stillbirth, institutionalisation for respiratory distress syndrome (RDS), sepsis, seizure during infancy, and infant death.

RESULTS

Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) for infants born to mothers with chronic hypertension who were dispensed beta-blockers only, as compared with infants born to mothers who were dispensed methyldopa only, during pregnancy were: 1.95 (1.21-3.15), 2.17 (1.06-4.44), and 2.17 (1.09-4.34), respectively, for SGA < 10th percentile, SGA < 3rd percentile, and being institutionalised during infancy.

CONCLUSIONS

For infants born to mothers with chronic hypertension, compared with those treated by methyldopa alone, those treated by beta-blockers appear to be at increased rates of SGA and hospitalisation during infancy.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Xie RH
Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou, China; OMNI Research Group, Department of Obstetrics and Gynaecology, University of Ottawa Faculty of Medicine, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Guo Y
No affiliation info available
Krewski D
No affiliation info available
Mattison D
No affiliation info available
Walker MC
No affiliation info available
Nerenberg K
No affiliation info available
Wen SW
No affiliation info available

MeSH

Adrenergic beta-AntagonistsAdultAntihypertensive AgentsFemaleHospitalizationHumansHypertensionHypertension, Pregnancy-InducedInfant, NewbornInfant, Small for Gestational AgeLogistic ModelsMethyldopaPregnancyPregnancy Complications, CardiovascularPregnancy OutcomeRetrospective StudiesRisk FactorsSaskatchewanTreatment Outcome

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24628701

Citation

Xie, R-h, et al. "Beta-blockers Increase the Risk of Being Born Small for Gestational Age or of Being Institutionalised During Infancy." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 121, no. 9, 2014, pp. 1090-6.
Xie RH, Guo Y, Krewski D, et al. Beta-blockers increase the risk of being born small for gestational age or of being institutionalised during infancy. BJOG. 2014;121(9):1090-6.
Xie, R. H., Guo, Y., Krewski, D., Mattison, D., Walker, M. C., Nerenberg, K., & Wen, S. W. (2014). Beta-blockers increase the risk of being born small for gestational age or of being institutionalised during infancy. BJOG : an International Journal of Obstetrics and Gynaecology, 121(9), 1090-6. https://doi.org/10.1111/1471-0528.12678
Xie RH, et al. Beta-blockers Increase the Risk of Being Born Small for Gestational Age or of Being Institutionalised During Infancy. BJOG. 2014;121(9):1090-6. PubMed PMID: 24628701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beta-blockers increase the risk of being born small for gestational age or of being institutionalised during infancy. AU - Xie,R-h, AU - Guo,Y, AU - Krewski,D, AU - Mattison,D, AU - Walker,M C, AU - Nerenberg,K, AU - Wen,S W, Y1 - 2014/03/17/ PY - 2013/12/19/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/9/12/medline KW - Adrenergic beta-antagonists KW - hypertension KW - infant KW - institutionalised KW - small for gestational age SP - 1090 EP - 6 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 121 IS - 9 N2 - OBJECTIVE: To compare infant outcomes between mothers with hypertension treated by beta-blockers alone and by methyldopa alone during pregnancy. DESIGN: Historical cohort study. SETTING: Saskatchewan, Canada. POPULATION: Women who delivered a singleton birth in Saskatchewan during the periods from 1 January 1980 to 30 June 1987 or from 1 January 1990 to 31 December 2005 (women who delivered between 1 July 1987 and 31 December 1989 were excluded because the information recorded on maternal drug use during pregnancy is incomplete) with a diagnosis of a hypertensive disorder during pregnancy, and who were dispensed only beta-blockers (n = 416) or only methyldopa (n = 1000). METHODS: Occurrences of adverse infant outcomes were compared between women who received beta-blockers only and women who received methyldopa only during pregnancy, first in all eligible women, and then in women with chronic hypertension and in women with gestational hypertension or pre-eclampsia/eclampsia, separately. Multiple logistic regression analyses were performed to adjust for potential confounding. MAIN OUTCOME MEASURES: Small for gestational age (SGA) < 10th percentile, SGA < 3rd percentile, preterm birth, stillbirth, institutionalisation for respiratory distress syndrome (RDS), sepsis, seizure during infancy, and infant death. RESULTS: Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) for infants born to mothers with chronic hypertension who were dispensed beta-blockers only, as compared with infants born to mothers who were dispensed methyldopa only, during pregnancy were: 1.95 (1.21-3.15), 2.17 (1.06-4.44), and 2.17 (1.09-4.34), respectively, for SGA < 10th percentile, SGA < 3rd percentile, and being institutionalised during infancy. CONCLUSIONS: For infants born to mothers with chronic hypertension, compared with those treated by methyldopa alone, those treated by beta-blockers appear to be at increased rates of SGA and hospitalisation during infancy. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/24628701/Beta_blockers_increase_the_risk_of_being_born_small_for_gestational_age_or_of_being_institutionalised_during_infancy_ DB - PRIME DP - Unbound Medicine ER -