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Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study.
BMC Cancer 2014; 14:187BC

Abstract

BACKGROUND

Prospective data on alcohol consumption, cigarette smoking and risk of head-neck cancer (HNC) subtypes, i.e. oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), are limited. We investigated these associations within the second largest prospective study on this topic so far, the Netherlands Cohort Study.

METHODS

120,852 participants completed a questionnaire on diet and other cancer risk factors in 1986. After 17.3 years of follow-up, 395 HNC (110 OCC, 83 OHPC, and 199 LC) cases and 4288 subcohort members were available for case-cohort analysis using Cox proportional hazards models.

RESULTS

For total HNC, the multivariable adjusted incidence rate ratio (RR) was 2.74 (95% confidence interval (CI) 1.85-4.06) for those drinking ≥30 g ethanol/day compared with abstainers; in subtypes, RRs were 6.39 for OCC, 3.52 for OHPC, and 1.54 for LC. Compared with never cigarette smokers, current cigarette smokers had a RR of 4.49 (95%CI 3.11-6.48) for HNC overall, and 2.11 for OCC, 8.53 for OHPC, and 8.07 for LC. A significant, positive, multiplicative interaction between categories of alcohol consumption and cigarette smoking was found for HNC overall (P interaction 0.03).

CONCLUSIONS

Alcohol consumption and cigarette smoking were independently associated with risk of HNC overall, with a positive, multiplicative interaction. The strength of these associations differed among HNC-subtypes: OCC was most strongly associated with alcohol consumption but most weakly with cigarette smoking, whereas LC was not statistically significantly associated with alcohol consumption.

Authors+Show Affiliations

Department of Epidemiology, GROW - School for Oncology & Developmental Biology, Maastricht University, P,O, Box 616 Maastricht 6200, MD, The Netherlands. denise.maasland@maastrichtuniversity.nl.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24629046

Citation

Maasland, Denise H E., et al. "Alcohol Consumption, Cigarette Smoking and the Risk of Subtypes of Head-neck Cancer: Results From the Netherlands Cohort Study." BMC Cancer, vol. 14, 2014, p. 187.
Maasland DH, van den Brandt PA, Kremer B, et al. Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study. BMC Cancer. 2014;14:187.
Maasland, D. H., van den Brandt, P. A., Kremer, B., Goldbohm, R. A., & Schouten, L. J. (2014). Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study. BMC Cancer, 14, p. 187. doi:10.1186/1471-2407-14-187.
Maasland DH, et al. Alcohol Consumption, Cigarette Smoking and the Risk of Subtypes of Head-neck Cancer: Results From the Netherlands Cohort Study. BMC Cancer. 2014 Mar 14;14:187. PubMed PMID: 24629046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study. AU - Maasland,Denise H E, AU - van den Brandt,Piet A, AU - Kremer,Bernd, AU - Goldbohm,R Alexandra Sandra, AU - Schouten,Leo J, Y1 - 2014/03/14/ PY - 2013/10/11/received PY - 2014/02/27/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/11/7/medline SP - 187 EP - 187 JF - BMC cancer JO - BMC Cancer VL - 14 N2 - BACKGROUND: Prospective data on alcohol consumption, cigarette smoking and risk of head-neck cancer (HNC) subtypes, i.e. oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), are limited. We investigated these associations within the second largest prospective study on this topic so far, the Netherlands Cohort Study. METHODS: 120,852 participants completed a questionnaire on diet and other cancer risk factors in 1986. After 17.3 years of follow-up, 395 HNC (110 OCC, 83 OHPC, and 199 LC) cases and 4288 subcohort members were available for case-cohort analysis using Cox proportional hazards models. RESULTS: For total HNC, the multivariable adjusted incidence rate ratio (RR) was 2.74 (95% confidence interval (CI) 1.85-4.06) for those drinking ≥30 g ethanol/day compared with abstainers; in subtypes, RRs were 6.39 for OCC, 3.52 for OHPC, and 1.54 for LC. Compared with never cigarette smokers, current cigarette smokers had a RR of 4.49 (95%CI 3.11-6.48) for HNC overall, and 2.11 for OCC, 8.53 for OHPC, and 8.07 for LC. A significant, positive, multiplicative interaction between categories of alcohol consumption and cigarette smoking was found for HNC overall (P interaction 0.03). CONCLUSIONS: Alcohol consumption and cigarette smoking were independently associated with risk of HNC overall, with a positive, multiplicative interaction. The strength of these associations differed among HNC-subtypes: OCC was most strongly associated with alcohol consumption but most weakly with cigarette smoking, whereas LC was not statistically significantly associated with alcohol consumption. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/24629046/Alcohol_consumption_cigarette_smoking_and_the_risk_of_subtypes_of_head_neck_cancer:_results_from_the_Netherlands_Cohort_Study_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-187 DB - PRIME DP - Unbound Medicine ER -