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Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies.
J Formos Med Assoc. 2014 Mar; 113(3):155-60.JF

Abstract

BACKGROUND/PURPOSE

Autoimmune thyroiditis can be diagnosed by measuring patients' serum levels of thyroid stimulating hormone (TSH), anti-thyroglobulin antibody (TGA), and anti-thyroid microsomal antibody (TMA). This study evaluated whether there were hematinic deficiencies, high blood homocysteine levels, and serum gastric parietal cell antibody (GPCA) positivity in patients with TGA or TMA.

METHODS

The blood hemoglobin (Hb), iron, vitamin B12, folic acid, homocysteine and TSH concentrations and the serum GPCA level in 190 TGA- or TMA-positive patients were measured and compared with the corresponding levels in 190 age- and sex-matched healthy control subjects.

RESULTS

We found that 31 (16.3%), 27 (14.2%), 12 (6.3%), and 2 (1.1%) TGA- or TMA-positive patients had deficiencies of Hb (Men<13g/dL, Women<12g/dL), iron (< 60μg/dL), vitamin B12 (< 200pg/mL), and folic acid (< 4ng/mL), respectively. Moreover, 25 (13.2%) and 48 (25.3%) TGA- or TMA-positive patients had abnormally high blood homocysteine level and serum GPCA positivity, respectively. TGA- or TMA-positive patients had a significantly higher frequency of Hb (p<0.001), iron (p<0.001), or vitamin B12 deficiency (p=0.001), of abnormally elevated blood homocysteine level (p=0.001), or of serum GPCA positivity (p<0.001) than healthy control subjects. Of 190 TGA- or TMA-positive patients, 8 (4.2%) had lower serum TSH level (< 0.1μIU/mL, suggestive of hyperthyroidism), 163 (85.8%) had serum TSH level within normal range (0.1-4.5μIU/mL), and 19 (10%) had higher serum TSH level (>4.5μIU/mL, suggestive of hypothyroidis).

CONCLUSION

There are significant deficiencies of hemoglobin, iron, and vitamin B12, abnormally high blood homocysteine levels, and serum GPCA positivity in TGA- or TMA-positive patients. In addition, the majority (85.8%) of TGA- or TMA-positive patients had euthyroid and only a small portion (14.2%) of TGA- or TMA-positive patients had either hypothyroidism or hyperthyroidism.

Authors+Show Affiliations

Graduate Institute of Clinical Dentistry, National Taiwan University, Taipei, Taiwan; School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, National Taiwan University, Taipei, Taiwan; School of Dentistry, National Taiwan University, Taipei, Taiwan.School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, Taipei, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, Taipei, Taiwan.School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24630032

Citation

Wang, Yi-Ping, et al. "Hemoglobin, Iron, and Vitamin B12 Deficiencies and High Blood Homocysteine Levels in Patients With Anti-thyroid Autoantibodies." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 113, no. 3, 2014, pp. 155-60.
Wang YP, Lin HP, Chen HM, et al. Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies. J Formos Med Assoc. 2014;113(3):155-60.
Wang, Y. P., Lin, H. P., Chen, H. M., Kuo, Y. S., Lang, M. J., & Sun, A. (2014). Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 113(3), 155-60. https://doi.org/10.1016/j.jfma.2012.04.003
Wang YP, et al. Hemoglobin, Iron, and Vitamin B12 Deficiencies and High Blood Homocysteine Levels in Patients With Anti-thyroid Autoantibodies. J Formos Med Assoc. 2014;113(3):155-60. PubMed PMID: 24630032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies. AU - Wang,Yi-Ping, AU - Lin,Hung-Pin, AU - Chen,Hsin-Ming, AU - Kuo,Ying-Shiung, AU - Lang,Ming-Jane, AU - Sun,Andy, Y1 - 2012/06/29/ PY - 2012/03/15/received PY - 2012/04/09/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/9/4/medline KW - anti-thyroglobulin antibody KW - anti-thyroid microsomal antibody KW - hemoglobin KW - homocysteine KW - iron KW - vitamin B12 SP - 155 EP - 60 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 113 IS - 3 N2 - BACKGROUND/PURPOSE: Autoimmune thyroiditis can be diagnosed by measuring patients' serum levels of thyroid stimulating hormone (TSH), anti-thyroglobulin antibody (TGA), and anti-thyroid microsomal antibody (TMA). This study evaluated whether there were hematinic deficiencies, high blood homocysteine levels, and serum gastric parietal cell antibody (GPCA) positivity in patients with TGA or TMA. METHODS: The blood hemoglobin (Hb), iron, vitamin B12, folic acid, homocysteine and TSH concentrations and the serum GPCA level in 190 TGA- or TMA-positive patients were measured and compared with the corresponding levels in 190 age- and sex-matched healthy control subjects. RESULTS: We found that 31 (16.3%), 27 (14.2%), 12 (6.3%), and 2 (1.1%) TGA- or TMA-positive patients had deficiencies of Hb (Men<13g/dL, Women<12g/dL), iron (< 60μg/dL), vitamin B12 (< 200pg/mL), and folic acid (< 4ng/mL), respectively. Moreover, 25 (13.2%) and 48 (25.3%) TGA- or TMA-positive patients had abnormally high blood homocysteine level and serum GPCA positivity, respectively. TGA- or TMA-positive patients had a significantly higher frequency of Hb (p<0.001), iron (p<0.001), or vitamin B12 deficiency (p=0.001), of abnormally elevated blood homocysteine level (p=0.001), or of serum GPCA positivity (p<0.001) than healthy control subjects. Of 190 TGA- or TMA-positive patients, 8 (4.2%) had lower serum TSH level (< 0.1μIU/mL, suggestive of hyperthyroidism), 163 (85.8%) had serum TSH level within normal range (0.1-4.5μIU/mL), and 19 (10%) had higher serum TSH level (>4.5μIU/mL, suggestive of hypothyroidis). CONCLUSION: There are significant deficiencies of hemoglobin, iron, and vitamin B12, abnormally high blood homocysteine levels, and serum GPCA positivity in TGA- or TMA-positive patients. In addition, the majority (85.8%) of TGA- or TMA-positive patients had euthyroid and only a small portion (14.2%) of TGA- or TMA-positive patients had either hypothyroidism or hyperthyroidism. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/24630032/Hemoglobin_iron_and_vitamin_B12_deficiencies_and_high_blood_homocysteine_levels_in_patients_with_anti_thyroid_autoantibodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(12)00271-9 DB - PRIME DP - Unbound Medicine ER -