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[YEL-AND meningoencephalitis in a 4-year-old boy consecutive to a yellow-fever vaccine].
Arch Pediatr. 2014 Apr; 21(4):384-7.AP

Abstract

Yellow fever is a vector-borne disease transmitted by an endemic mosquito in sub-Saharan Africa and tropical South America. It causes fever and possibly liver and renal failure with hemorrhagic signs, which may be fatal. The yellow-fever vaccine is an attenuated vaccine that is recommended for all travelers over the age of 9 months in high-risk areas. Adverse effects have been reported: minor symptoms (such as viral syndrome), hypersensitivity reactions, and major symptoms such as viscerotropic disease (YEL-AVD) and neurotropic disease (YEL-AND). The yellow-fever vaccine-associated autoimmune disease with central nervous system involvement (such as acute disseminated encephalomyelitis) associates fever and headaches, neurologic dysfunction, seizures, cerebrospinal fluid (CSF) pleocytosis, and elevated protein, with neuroimaging consistent with multifocal areas of demyelization. The presence of antibodies or virus in CSF, within 1-30 days following vaccination, and the exclusion of other causes is necessary for diagnosis. We describe herein the case of a 4-year-old child who presented with severe encephalitis consecutive to a yellow-fever vaccine, with favorable progression. Diagnosis is based on the chronology of clinical and paraclinical signs and the presence of yellow-fever-specific antibodies in CSF. The treatment consists of symptomatic treatment and immunoglobulin injection.

Authors+Show Affiliations

Clinique universitaire de pédiatrie, hôpital couple-enfant, 38000 Grenoble, France. Electronic address: mgerin@chu-grenoble.fr.Clinique universitaire de réanimation pédiatrique et médecine néonatale, hôpital couple-enfant, 38000 Grenoble, France.Clinique universitaire de pédiatrie, hôpital couple-enfant, 38000 Grenoble, France.Clinique universitaire de pédiatrie, hôpital couple-enfant, 38000 Grenoble, France.Clinique universitaire de réanimation pédiatrique et médecine néonatale, hôpital couple-enfant, 38000 Grenoble, France.

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

24630625

Citation

Gerin, M, et al. "[YEL-AND Meningoencephalitis in a 4-year-old Boy Consecutive to a Yellow-fever Vaccine]." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 21, no. 4, 2014, pp. 384-7.
Gerin M, Wroblewski I, Bost-Bru C, et al. [YEL-AND meningoencephalitis in a 4-year-old boy consecutive to a yellow-fever vaccine]. Arch Pediatr. 2014;21(4):384-7.
Gerin, M., Wroblewski, I., Bost-Bru, C., N'guyen, M. A., & Debillon, T. (2014). [YEL-AND meningoencephalitis in a 4-year-old boy consecutive to a yellow-fever vaccine]. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 21(4), 384-7. https://doi.org/10.1016/j.arcped.2014.01.014
Gerin M, et al. [YEL-AND Meningoencephalitis in a 4-year-old Boy Consecutive to a Yellow-fever Vaccine]. Arch Pediatr. 2014;21(4):384-7. PubMed PMID: 24630625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [YEL-AND meningoencephalitis in a 4-year-old boy consecutive to a yellow-fever vaccine]. AU - Gerin,M, AU - Wroblewski,I, AU - Bost-Bru,C, AU - N'guyen,M-A, AU - Debillon,T, Y1 - 2014/03/12/ PY - 2013/04/23/received PY - 2013/09/15/revised PY - 2014/01/18/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2015/1/20/medline SP - 384 EP - 7 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 21 IS - 4 N2 - Yellow fever is a vector-borne disease transmitted by an endemic mosquito in sub-Saharan Africa and tropical South America. It causes fever and possibly liver and renal failure with hemorrhagic signs, which may be fatal. The yellow-fever vaccine is an attenuated vaccine that is recommended for all travelers over the age of 9 months in high-risk areas. Adverse effects have been reported: minor symptoms (such as viral syndrome), hypersensitivity reactions, and major symptoms such as viscerotropic disease (YEL-AVD) and neurotropic disease (YEL-AND). The yellow-fever vaccine-associated autoimmune disease with central nervous system involvement (such as acute disseminated encephalomyelitis) associates fever and headaches, neurologic dysfunction, seizures, cerebrospinal fluid (CSF) pleocytosis, and elevated protein, with neuroimaging consistent with multifocal areas of demyelization. The presence of antibodies or virus in CSF, within 1-30 days following vaccination, and the exclusion of other causes is necessary for diagnosis. We describe herein the case of a 4-year-old child who presented with severe encephalitis consecutive to a yellow-fever vaccine, with favorable progression. Diagnosis is based on the chronology of clinical and paraclinical signs and the presence of yellow-fever-specific antibodies in CSF. The treatment consists of symptomatic treatment and immunoglobulin injection. SN - 1769-664X UR - https://www.unboundmedicine.com/medline/citation/24630625/[YEL_AND_meningoencephalitis_in_a_4_year_old_boy_consecutive_to_a_yellow_fever_vaccine]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-693X(14)00035-9 DB - PRIME DP - Unbound Medicine ER -