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Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control.
Diabetes Metab. 2014 Sep; 40(4):272-7.DM

Abstract

AIMS

This study investigated the relationship between markers of overall glucose exposure, postprandial glucose excursions and glycaemic variability in patients with type 2 diabetes mellitus (T2DM).

METHODS

A total of 63 patients with T2DM (mean age 56 years) were enrolled. All wore a continuous glucose monitoring system (CGMS) device for 72 h to collect data on markers of overall glucose exposure, postprandial glucose excursions and glycaemic variability parameters.

RESULTS

Spearman's correlation analysis revealed significant correlations between all markers of overall glucose exposure and various parameters related to glucose excursions. The percent coefficient of variation (CV) showed the strongest correlation with glycated albumin (r=0.470, P<0.01). In participants with HbA1c levels < 7.5% (n=33), almost all glycaemic markers and glycaemic variability parameters were significantly correlated with each other. Also, all postprandial glucose excursion parameters showed significant correlation with other glycaemic markers, and all markers of overall glucose exposure were significantly related to mean glucose, postprandial glucose excursions and glycaemic variability parameters (except CV). In contrast, in participants with HbA1c levels ≥ 7.5% (n=30), no parameters of postprandial glucose excursions and glycaemic variability were related to any markers of chronic glycaemia.

CONCLUSION

Postprandial glucose excursions may explain glycaemic variability and total glucose exposures in well-controlled T2DM patients.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 135-710 Seoul, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 135-710 Seoul, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 135-710 Seoul, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 135-710 Seoul, Republic of Korea.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 135-710 Seoul, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 135-710 Seoul, Republic of Korea.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-Dong, Gangnam-Gu, 135-710 Seoul, Republic of Korea. Electronic address: jaehyeon@skku.edu.

MeSH

AgedBiomarkersBlood GlucoseDiabetes Mellitus, Type 2Dietary CarbohydratesFemaleGlucoseGlycated HemoglobinGlycation End Products, AdvancedHumansHypoglycemic AgentsMaleMiddle AgedPostprandial PeriodSerum AlbuminGlycated Serum Albumin

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24630733

Citation

Suh, S, et al. "Strong Correlation Between Glycaemic Variability and Total Glucose Exposure in Type 2 Diabetes Is Limited to Subjects With Satisfactory Glycaemic Control." Diabetes & Metabolism, vol. 40, no. 4, 2014, pp. 272-7.

Suh S, Joung JY, Jin SM, et al. Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control. Diabetes Metab. 2014;40(4):272-7.

Suh, S., Joung, J. Y., Jin, S. M., Kim, M. Y., Bae, J. C., Park, H. D., Lee, M. S., Lee, M. K., & Kim, J. H. (2014). Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control. Diabetes & Metabolism, 40(4), 272-7. https://doi.org/10.1016/j.diabet.2014.01.006

Suh S, et al. Strong Correlation Between Glycaemic Variability and Total Glucose Exposure in Type 2 Diabetes Is Limited to Subjects With Satisfactory Glycaemic Control. Diabetes Metab. 2014;40(4):272-7. PubMed PMID: 24630733.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control. AU - Suh,S, AU - Joung,J Y, AU - Jin,S M, AU - Kim,M Y, AU - Bae,J C, AU - Park,H D, AU - Lee,M S, AU - Lee,M K, AU - Kim,J H, Y1 - 2014/03/11/ PY - 2013/12/03/received PY - 2014/01/24/revised PY - 2014/01/30/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2015/5/28/medline KW - 1,5-Anhydroglucitol KW - Continuous glucose monitoring systems KW - Fructosamine KW - Glycated albumin KW - HbA(1c) SP - 272 EP - 7 JF - Diabetes & metabolism JO - Diabetes Metab VL - 40 IS - 4 N2 - AIMS: This study investigated the relationship between markers of overall glucose exposure, postprandial glucose excursions and glycaemic variability in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 63 patients with T2DM (mean age 56 years) were enrolled. All wore a continuous glucose monitoring system (CGMS) device for 72 h to collect data on markers of overall glucose exposure, postprandial glucose excursions and glycaemic variability parameters. RESULTS: Spearman's correlation analysis revealed significant correlations between all markers of overall glucose exposure and various parameters related to glucose excursions. The percent coefficient of variation (CV) showed the strongest correlation with glycated albumin (r=0.470, P<0.01). In participants with HbA1c levels < 7.5% (n=33), almost all glycaemic markers and glycaemic variability parameters were significantly correlated with each other. Also, all postprandial glucose excursion parameters showed significant correlation with other glycaemic markers, and all markers of overall glucose exposure were significantly related to mean glucose, postprandial glucose excursions and glycaemic variability parameters (except CV). In contrast, in participants with HbA1c levels ≥ 7.5% (n=30), no parameters of postprandial glucose excursions and glycaemic variability were related to any markers of chronic glycaemia. CONCLUSION: Postprandial glucose excursions may explain glycaemic variability and total glucose exposures in well-controlled T2DM patients. SN - 1878-1780 UR - https://www.unboundmedicine.com/medline/citation/24630733/Strong_correlation_between_glycaemic_variability_and_total_glucose_exposure_in_type_2_diabetes_is_limited_to_subjects_with_satisfactory_glycaemic_control_ DB - PRIME DP - Unbound Medicine ER -