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A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls.

Abstract

BACKGROUND

Poor diet and a sedentary lifestyle can contribute to nonalcoholic fatty liver disease (NAFLD).

OBJECTIVE

Our aim was to compare diet and physical activity of patients with NAFLD and healthy controls with current recommendations.

DESIGN

This was a cross-sectional study.

PARTICIPANTS/SETTINGS

Seventy-four patients with biopsy-proven NAFLD (33 simple steatosis and 41 steatohepatitis [NASH]) and 27 healthy controls participated between 2003 and 2011.

MAIN OUTCOME MEASURES

Food records and activity logs were completed for 7 days. Results were compared with Dietary Reference Intakes and Canadian Physical Activity Guidelines. Plasma vitamin C was measured to assess food record accuracy.

STATISTICAL ANALYSES PERFORMED

Intake/activity for each participant was compared with the recommendations and proportion of subjects not meeting the requirements was calculated. Groups were compared by Kruskal-Wallis and Mann-Whitney U test or z-test with Bonferroni adjustment.

RESULTS

More patients with NASH (58.5%) were obese compared with patients with simple steatosis (24.2%) and healthy controls (7.4%; P<0.01). Patients with NAFLD showed more insulin resistance than healthy controls. The reported energy intake was below estimated requirements in all groups (P≤0.001). The proportion of subjects from each group exceeding acceptable energy intake from fat was as follows: simple steatosis: 27.3%; NASH: 46.3%; healthy controls: 63.0% (simple steatosis vs health controls; P<0.05) and from saturated fat: simple steatosis: 42.4%; NASH: 70.7%; healthy controls: 63.0% (simple steatosis vs. NASH; P<0.05). In each group, >80% of subjects did not consume enough linoleic or linolenic acid, vitamin D, and vitamin E, and >60% exceeded the upper intake level for sodium. Only 53.1% of patients with simple steatosis and 53.8% of patients with NASH, but 84.6% of healthy controls, met recommendations for physical activity (P=0.020). Plasma vitamin C was normal, similar among groups, and correlated with vitamin C intakes.

CONCLUSIONS

All participants followed a similar Western diet with high fat and sodium intakes and suboptimal micronutrient intakes. However, physical activity was lower in NAFLD compared with healthy controls and was associated with higher body mass index and insulin resistance.

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    MeSH

    Adult
    Aged
    Ascorbic Acid
    Body Mass Index
    Canada
    Case-Control Studies
    Cross-Sectional Studies
    Diet Records
    Dietary Fats
    Energy Intake
    Fatty Liver
    Female
    Guidelines as Topic
    Healthy Volunteers
    Humans
    Insulin Resistance
    Male
    Middle Aged
    Motor Activity
    Non-alcoholic Fatty Liver Disease
    Nutrition Assessment
    Prospective Studies
    Sodium, Dietary
    Vitamin D
    Vitamin E
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24631112

    Citation

    Da Silva, Hannah E., et al. "A Cross-sectional Study Assessing Dietary Intake and Physical Activity in Canadian Patients With Nonalcoholic Fatty Liver Disease Vs Healthy Controls." Journal of the Academy of Nutrition and Dietetics, vol. 114, no. 8, 2014, pp. 1181-94.
    Da Silva HE, Arendt BM, Noureldin SA, et al. A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls. J Acad Nutr Diet. 2014;114(8):1181-94.
    Da Silva, H. E., Arendt, B. M., Noureldin, S. A., Therapondos, G., Guindi, M., & Allard, J. P. (2014). A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls. Journal of the Academy of Nutrition and Dietetics, 114(8), pp. 1181-94. doi:10.1016/j.jand.2014.01.009.
    Da Silva HE, et al. A Cross-sectional Study Assessing Dietary Intake and Physical Activity in Canadian Patients With Nonalcoholic Fatty Liver Disease Vs Healthy Controls. J Acad Nutr Diet. 2014;114(8):1181-94. PubMed PMID: 24631112.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls. AU - Da Silva,Hannah E, AU - Arendt,Bianca M, AU - Noureldin,Seham A, AU - Therapondos,George, AU - Guindi,Maha, AU - Allard,Johane P, Y1 - 2014/03/14/ PY - 2012/05/15/received PY - 2014/01/06/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/9/16/medline KW - Diet KW - Nonalcoholic fatty liver disease KW - Nutrient intake KW - Physical activity KW - Steatohepatitis SP - 1181 EP - 94 JF - Journal of the Academy of Nutrition and Dietetics JO - J Acad Nutr Diet VL - 114 IS - 8 N2 - BACKGROUND: Poor diet and a sedentary lifestyle can contribute to nonalcoholic fatty liver disease (NAFLD). OBJECTIVE: Our aim was to compare diet and physical activity of patients with NAFLD and healthy controls with current recommendations. DESIGN: This was a cross-sectional study. PARTICIPANTS/SETTINGS: Seventy-four patients with biopsy-proven NAFLD (33 simple steatosis and 41 steatohepatitis [NASH]) and 27 healthy controls participated between 2003 and 2011. MAIN OUTCOME MEASURES: Food records and activity logs were completed for 7 days. Results were compared with Dietary Reference Intakes and Canadian Physical Activity Guidelines. Plasma vitamin C was measured to assess food record accuracy. STATISTICAL ANALYSES PERFORMED: Intake/activity for each participant was compared with the recommendations and proportion of subjects not meeting the requirements was calculated. Groups were compared by Kruskal-Wallis and Mann-Whitney U test or z-test with Bonferroni adjustment. RESULTS: More patients with NASH (58.5%) were obese compared with patients with simple steatosis (24.2%) and healthy controls (7.4%; P<0.01). Patients with NAFLD showed more insulin resistance than healthy controls. The reported energy intake was below estimated requirements in all groups (P≤0.001). The proportion of subjects from each group exceeding acceptable energy intake from fat was as follows: simple steatosis: 27.3%; NASH: 46.3%; healthy controls: 63.0% (simple steatosis vs health controls; P<0.05) and from saturated fat: simple steatosis: 42.4%; NASH: 70.7%; healthy controls: 63.0% (simple steatosis vs. NASH; P<0.05). In each group, >80% of subjects did not consume enough linoleic or linolenic acid, vitamin D, and vitamin E, and >60% exceeded the upper intake level for sodium. Only 53.1% of patients with simple steatosis and 53.8% of patients with NASH, but 84.6% of healthy controls, met recommendations for physical activity (P=0.020). Plasma vitamin C was normal, similar among groups, and correlated with vitamin C intakes. CONCLUSIONS: All participants followed a similar Western diet with high fat and sodium intakes and suboptimal micronutrient intakes. However, physical activity was lower in NAFLD compared with healthy controls and was associated with higher body mass index and insulin resistance. SN - 2212-2672 UR - https://www.unboundmedicine.com/medline/citation/24631112/A_cross_sectional_study_assessing_dietary_intake_and_physical_activity_in_Canadian_patients_with_nonalcoholic_fatty_liver_disease_vs_healthy_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-2672(14)00099-9 DB - PRIME DP - Unbound Medicine ER -