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Association analysis of STK39, MCCC1/LAMP3 and sporadic PD in the Chinese Han population.
Neurosci Lett. 2014 Apr 30; 566:206-9.NL

Abstract

With the completion of the Human Genome Project, GWAS have been widely used in exploring the genetic studies of complex diseases. A meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe found 11 loci that surpassed the threshold for genome-wide significance (p<5×10(-8)), and five were newly identified loci (ACMSD, STK39, MCCC1/LAMP3, SYT11 and CCDC62/HIP1R). Another GWAS of the Ashkenazi Jewish population also identified loci in STK39 and LAMP3. Because the association between the STK39 and MCCC1/LAMP3 genes and PD was confirmed in different populations, we conducted a case-control cohort to clarify the association between the four single nucleotide polymorphism (SNP) loci (rs2102808 and rs3754775 in the STK39; rs11711441 and rs12493050 in the MCCC1/LAMP3) and PD in the Chinese Han population. Polymerase chain reaction and direct DNA sequencing analyses were used to detect the four variations in a case-control cohort comprised of 993 ethnic Chinese subjects. We found that in the detection of the rs11711441, there was a significant difference between ungrouped populations, early-onset PD, late-onset PD, male PD, female PD and the corresponding control group in allele and genotype frequency (p<0.001, OR<1). In the detection of the rs2102808, rs3754775 and rs12493050, ungrouped populations, early-onset PD, late-onset PD, male PD or female PD with the corresponding control group showed no significant difference in allele and genotype frequency (p>0.0125). Our findings suggested that the allele G of rs11711441 of the MCCC1/LAMP3 gene can decrease the risk of PD in Chinese population. No statistically significant difference in genotype frequency between cases and controls was observed for the other three SNPs.

Authors+Show Affiliations

Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha 410008, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha 410008, Hunan, People's Republic of China.Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People's Republic of China; State Key Laboratory of Medical Genetics, Changsha 410008, Hunan, People's Republic of China; Human Key Laboratory of Neurodegenerative Disorders, Central South University, Changsha 410008, Hunan, People's Republic of China; Neurodegenerative Disorders Research Center, Central South University, Changsha 410008, Hunan, People's Republic of China. Electronic address: guojifeng2003@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24631562

Citation

Wang, Ya-qin, et al. "Association Analysis of STK39, MCCC1/LAMP3 and Sporadic PD in the Chinese Han Population." Neuroscience Letters, vol. 566, 2014, pp. 206-9.
Wang YQ, Tang BS, Yu RL, et al. Association analysis of STK39, MCCC1/LAMP3 and sporadic PD in the Chinese Han population. Neurosci Lett. 2014;566:206-9.
Wang, Y. Q., Tang, B. S., Yu, R. L., Li, K., Liu, Z. H., Xu, Q., Sun, Q. Y., Yan, X. X., & Guo, J. F. (2014). Association analysis of STK39, MCCC1/LAMP3 and sporadic PD in the Chinese Han population. Neuroscience Letters, 566, 206-9. https://doi.org/10.1016/j.neulet.2014.03.007
Wang YQ, et al. Association Analysis of STK39, MCCC1/LAMP3 and Sporadic PD in the Chinese Han Population. Neurosci Lett. 2014 Apr 30;566:206-9. PubMed PMID: 24631562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association analysis of STK39, MCCC1/LAMP3 and sporadic PD in the Chinese Han population. AU - Wang,Ya-qin, AU - Tang,Bei-sha, AU - Yu,Ri-li, AU - Li,Kai, AU - Liu,Zhen-hua, AU - Xu,Qian, AU - Sun,Qi-ying, AU - Yan,Xin-xiang, AU - Guo,Ji-feng, Y1 - 2014/03/12/ PY - 2013/12/17/received PY - 2014/03/02/revised PY - 2014/03/04/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/11/12/medline KW - GWAS KW - Parkinson's disease KW - SNP SP - 206 EP - 9 JF - Neuroscience letters JO - Neurosci Lett VL - 566 N2 - With the completion of the Human Genome Project, GWAS have been widely used in exploring the genetic studies of complex diseases. A meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe found 11 loci that surpassed the threshold for genome-wide significance (p<5×10(-8)), and five were newly identified loci (ACMSD, STK39, MCCC1/LAMP3, SYT11 and CCDC62/HIP1R). Another GWAS of the Ashkenazi Jewish population also identified loci in STK39 and LAMP3. Because the association between the STK39 and MCCC1/LAMP3 genes and PD was confirmed in different populations, we conducted a case-control cohort to clarify the association between the four single nucleotide polymorphism (SNP) loci (rs2102808 and rs3754775 in the STK39; rs11711441 and rs12493050 in the MCCC1/LAMP3) and PD in the Chinese Han population. Polymerase chain reaction and direct DNA sequencing analyses were used to detect the four variations in a case-control cohort comprised of 993 ethnic Chinese subjects. We found that in the detection of the rs11711441, there was a significant difference between ungrouped populations, early-onset PD, late-onset PD, male PD, female PD and the corresponding control group in allele and genotype frequency (p<0.001, OR<1). In the detection of the rs2102808, rs3754775 and rs12493050, ungrouped populations, early-onset PD, late-onset PD, male PD or female PD with the corresponding control group showed no significant difference in allele and genotype frequency (p>0.0125). Our findings suggested that the allele G of rs11711441 of the MCCC1/LAMP3 gene can decrease the risk of PD in Chinese population. No statistically significant difference in genotype frequency between cases and controls was observed for the other three SNPs. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/24631562/Association_analysis_of_STK39_MCCC1/LAMP3_and_sporadic_PD_in_the_Chinese_Han_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(14)00197-9 DB - PRIME DP - Unbound Medicine ER -