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Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia.
Fitoterapia. 2014 Jun; 95:75-82.F

Abstract

Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (7), 5β,19-epoxycucurbita-6, 23-diene-3β,19,25-triol (8), kuguacin R (9), and (19R,23E)-5β,19-epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 14.3-20.5μmol/L.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhao GT
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, People's Republic of China.
Liu JQ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
Deng YY
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of Chinese Academy of Science, Beijing 100049, People's Republic of China.
Li HZ
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, People's Republic of China.
Chen JC
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
Zhang ZR
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
Zhou L
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
Qiu MH
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of Chinese Academy of Science, Beijing 100049, People's Republic of China. Electronic address: mhchiu@mail.kib.ac.cn.

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalGlycosidesHumansInhibitory Concentration 50Magnetic Resonance SpectroscopyMolecular StructureMomordica charantiaPlant ExtractsPlant LeavesPlant StemsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24631764

Citation

Zhao, Gao-Ting, et al. "Cucurbitane-type Triterpenoids From the Stems and Leaves of Momordica Charantia." Fitoterapia, vol. 95, 2014, pp. 75-82.
Zhao GT, Liu JQ, Deng YY, et al. Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia. Fitoterapia. 2014;95:75-82.
Zhao, G. T., Liu, J. Q., Deng, Y. Y., Li, H. Z., Chen, J. C., Zhang, Z. R., Zhou, L., & Qiu, M. H. (2014). Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia. Fitoterapia, 95, 75-82. https://doi.org/10.1016/j.fitote.2014.03.005
Zhao GT, et al. Cucurbitane-type Triterpenoids From the Stems and Leaves of Momordica Charantia. Fitoterapia. 2014;95:75-82. PubMed PMID: 24631764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia. AU - Zhao,Gao-Ting, AU - Liu,Jie-Qing, AU - Deng,Yuan-Yuan, AU - Li,Hai-Zhou, AU - Chen,Jian-Chao, AU - Zhang,Zhi-Run, AU - Zhou,Lin, AU - Qiu,Ming-Hua, Y1 - 2014/03/14/ PY - 2014/01/20/received PY - 2014/02/26/revised PY - 2014/03/03/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2015/1/8/medline KW - Cucurbitaceae KW - Cucurbitane-type triterpenoids KW - Cytotoxicity KW - Momordica charantia SP - 75 EP - 82 JF - Fitoterapia JO - Fitoterapia VL - 95 N2 - Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (7), 5β,19-epoxycucurbita-6, 23-diene-3β,19,25-triol (8), kuguacin R (9), and (19R,23E)-5β,19-epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 14.3-20.5μmol/L. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/24631764/Cucurbitane_type_triterpenoids_from_the_stems_and_leaves_of_Momordica_charantia_ DB - PRIME DP - Unbound Medicine ER -