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Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China.
Acta Physiol Hung 2014; 101(1):59-66AP

Abstract

This study is to explore the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers.

METHODS

We conducted a cross-sectional study on 156 workers with occupational exposure to lead between 2002 and 2007. The results of laboratory examinations were analyzed.

RESULTS

The authors found that workers with the ALAD 1-1 genotype were associated with higher blood lead level than those with the ALADl-2 genotype. Blood and urine lead levels were much higher in storage battery workers than in cable workers. The urine ALA and blood ZPP levels in workers with the ALAD 1-1 genotype were higher than those with the ALADl-2 genotype. The serum Cr level in workers with the ALADl-1 genotype was much higher than those with the ALADl-2 genotype especially in higher lead exposure level.

CONCLUSIONS

The ALAD-2 protein might modify the kinetics of lead in blood at a relatively higher blood lead level and protect against hematopoietic, hepatic and renal toxicity from lead. Urine ALA, blood ZPP and serum Cr levels might be considered as effective biological monitoring partners of lead induced hematopoietic and renal toxicology.

Authors+Show Affiliations

Sichuan University West China Fourth Hospital of West China Public Health Institute No. 18, Section 3, Renmin Nanlu Chengdu P. R. China.Sichuan University West China Fourth Hospital of West China Public Health Institute No. 18, Section 3, Renmin Nanlu Chengdu P. R. China.Fudan University School of Public Health Shanghai P. R. China.Sichuan University West China Fourth Hospital of West China Public Health Institute No. 18, Section 3, Renmin Nanlu Chengdu P. R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24631795

Citation

Wan, H, et al. "Investigation of Delta-aminolevulinic Acid Dehydratase Polymorphism Affecting Hematopoietic, Hepatic and Renal Toxicity From Lead in Han Subjects of Southwestern China." Acta Physiologica Hungarica, vol. 101, no. 1, 2014, pp. 59-66.
Wan H, Wu J, Sun P, et al. Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China. Acta Physiol Hung. 2014;101(1):59-66.
Wan, H., Wu, J., Sun, P., & Yang, Y. (2014). Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China. Acta Physiologica Hungarica, 101(1), pp. 59-66. doi:10.1556/APhysiol.101.2014.1.7.
Wan H, et al. Investigation of Delta-aminolevulinic Acid Dehydratase Polymorphism Affecting Hematopoietic, Hepatic and Renal Toxicity From Lead in Han Subjects of Southwestern China. Acta Physiol Hung. 2014;101(1):59-66. PubMed PMID: 24631795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China. AU - Wan,H, AU - Wu,J, AU - Sun,P, AU - Yang,Yuelin, PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/8/12/medline KW - delta-aminolevulinic acid dehydratase KW - hematopoietic toxicity KW - hepatic toxicity KW - lead toxicity KW - occupational exposure KW - polymorphism KW - renal toxicity SP - 59 EP - 66 JF - Acta physiologica Hungarica JO - Acta Physiol Hung VL - 101 IS - 1 N2 - UNLABELLED: This study is to explore the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers. METHODS: We conducted a cross-sectional study on 156 workers with occupational exposure to lead between 2002 and 2007. The results of laboratory examinations were analyzed. RESULTS: The authors found that workers with the ALAD 1-1 genotype were associated with higher blood lead level than those with the ALADl-2 genotype. Blood and urine lead levels were much higher in storage battery workers than in cable workers. The urine ALA and blood ZPP levels in workers with the ALAD 1-1 genotype were higher than those with the ALADl-2 genotype. The serum Cr level in workers with the ALADl-1 genotype was much higher than those with the ALADl-2 genotype especially in higher lead exposure level. CONCLUSIONS: The ALAD-2 protein might modify the kinetics of lead in blood at a relatively higher blood lead level and protect against hematopoietic, hepatic and renal toxicity from lead. Urine ALA, blood ZPP and serum Cr levels might be considered as effective biological monitoring partners of lead induced hematopoietic and renal toxicology. SN - 0231-424X UR - https://www.unboundmedicine.com/medline/citation/24631795/Investigation_of_delta_aminolevulinic_acid_dehydratase_polymorphism_affecting_hematopoietic_hepatic_and_renal_toxicity_from_lead_in_Han_subjects_of_southwestern_China_ L2 - http://www.akademiai.com/doi/full/10.1556/APhysiol.101.2014.1.7?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -