Tags

Type your tag names separated by a space and hit enter

The involvement of distraction in memory deficits induced by NMDAR antagonism: relevance to cognitive deficits in schizophrenia.
Behav Brain Res. 2014 Jun 01; 266:188-92.BB

Abstract

Recognition memory, impaired in neuropsychiatric conditions and currently untreated, may be assessed by the novel object recognition (NOR) task with robust impairments induced by sub-chronic treatment with the N-methyl-d-aspartate receptor antagonist phencyclidine (PCP). The aim of the present study was to investigate how sub-chronic PCP produces its effects in this task. Forty adult female rats received vehicle or PCP (2mg/kg i.p. twice daily for 7 days followed by 7 days washout). Rats completed a 3-min acquisition trial followed by differential inter-trial-interval (ITI) conditions (1 min in the home cage, 10s in the home cage, 1 min in the NOR test box in the presence of an unfamiliar object or 1 min in the NOR test box completely undisturbed) followed by a 3-min retention trial. Control rats spent significantly more time exploring the novel compared with the familiar object in retention. This effect was abolished in the sub-chronic PCP treated animals following all ITI conditions except in rats left completely undisturbed in the NOR test box for a 1 min ITI. The combined influence of sub-chronic PCP treatment and the effect of distraction provides further support for the validity of the NOR test in mimicking cognitive deficits of relevance to schizophrenia.

Authors+Show Affiliations

Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK. Electronic address: Ben.grayson@manchester.ac.uk.Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK. Electronic address: Joanna.neill@manchester.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24632009

Citation

Grayson, Ben, et al. "The Involvement of Distraction in Memory Deficits Induced By NMDAR Antagonism: Relevance to Cognitive Deficits in Schizophrenia." Behavioural Brain Research, vol. 266, 2014, pp. 188-92.
Grayson B, Adamson L, Harte M, et al. The involvement of distraction in memory deficits induced by NMDAR antagonism: relevance to cognitive deficits in schizophrenia. Behav Brain Res. 2014;266:188-92.
Grayson, B., Adamson, L., Harte, M., Leger, M., Marsh, S., Piercy, C., & Neill, J. C. (2014). The involvement of distraction in memory deficits induced by NMDAR antagonism: relevance to cognitive deficits in schizophrenia. Behavioural Brain Research, 266, 188-92. https://doi.org/10.1016/j.bbr.2014.03.011
Grayson B, et al. The Involvement of Distraction in Memory Deficits Induced By NMDAR Antagonism: Relevance to Cognitive Deficits in Schizophrenia. Behav Brain Res. 2014 Jun 1;266:188-92. PubMed PMID: 24632009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The involvement of distraction in memory deficits induced by NMDAR antagonism: relevance to cognitive deficits in schizophrenia. AU - Grayson,Ben, AU - Adamson,Lisa, AU - Harte,Michael, AU - Leger,Marianne, AU - Marsh,Samuel, AU - Piercy,Chloe, AU - Neill,Joanna C, Y1 - 2014/03/13/ PY - 2014/02/10/received PY - 2014/03/04/revised PY - 2014/03/06/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/12/17/medline KW - Animal models KW - Cognition KW - Object recognition memory KW - Phencyclidine KW - Rat KW - Schizophrenia SP - 188 EP - 92 JF - Behavioural brain research JO - Behav Brain Res VL - 266 N2 - Recognition memory, impaired in neuropsychiatric conditions and currently untreated, may be assessed by the novel object recognition (NOR) task with robust impairments induced by sub-chronic treatment with the N-methyl-d-aspartate receptor antagonist phencyclidine (PCP). The aim of the present study was to investigate how sub-chronic PCP produces its effects in this task. Forty adult female rats received vehicle or PCP (2mg/kg i.p. twice daily for 7 days followed by 7 days washout). Rats completed a 3-min acquisition trial followed by differential inter-trial-interval (ITI) conditions (1 min in the home cage, 10s in the home cage, 1 min in the NOR test box in the presence of an unfamiliar object or 1 min in the NOR test box completely undisturbed) followed by a 3-min retention trial. Control rats spent significantly more time exploring the novel compared with the familiar object in retention. This effect was abolished in the sub-chronic PCP treated animals following all ITI conditions except in rats left completely undisturbed in the NOR test box for a 1 min ITI. The combined influence of sub-chronic PCP treatment and the effect of distraction provides further support for the validity of the NOR test in mimicking cognitive deficits of relevance to schizophrenia. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/24632009/The_involvement_of_distraction_in_memory_deficits_induced_by_NMDAR_antagonism:_relevance_to_cognitive_deficits_in_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(14)00157-0 DB - PRIME DP - Unbound Medicine ER -