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Effect of SNP polymorphisms of EDN1, EDNRA, and EDNRB gene on ischemic stroke.
Cell Biochem Biophys. 2014 Sep; 70(1):233-9.CB

Abstract

The objective of this study is to investigate the association between SNP polymorphisms of endothelin-1 (EDN1) and endothelin receptor (EDNRA and EDNRB) gene and ischemic stroke (IS) in the Chinese Han population in northern. A case-control study was introduced. We genotyped eight SNPs (rs1800541, rs2070699, and rs5370 in EDN1 gene; rs1801708, rs5333, and rs5335 in EDNRA gene; and rs3818416 and rs5351 in EDNRB gene) and calculated their polymorphic distribution in control group, IS group, and the IS subgroups. In male population, EDN1 gene rs2070699 G allele increased the incidence risk to 1.78 times (P = 0.009; OR 1.78; 95 % CI 1.15-2.75) and the risk of morbidity of rs5370 T allele carrying increased to 1.49 times (P = 0.048; OR 1.49; 95 % CI 1.00-2.21). EDNRA gene mutation rs5335 homozygous CC morbidity risk was significantly lower (P = 0.016; OR 0.52; 95 % CI 0.31-0.88). In the female population, the mutant homozygous AA cancer risk was significantly higher than G allele carriers (P = 0.019; OR 2.65; 95 % CI 1.18-6.00) on EDNRA gene rs1801708. In EDN1 gene, T allele of rs5370 and G allele of rs2070699 may be IS incidence risk factors in Northern Han male population. A allele of rs1801708 in EDNRA gene can increase the risk of IS in Northern Han women population.

Authors+Show Affiliations

School of Nursing, Liaoning Medical College, Jinzhou, China.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24633486

Citation

Zhang, Lei, and Rubo Sui. "Effect of SNP Polymorphisms of EDN1, EDNRA, and EDNRB Gene On Ischemic Stroke." Cell Biochemistry and Biophysics, vol. 70, no. 1, 2014, pp. 233-9.
Zhang L, Sui R. Effect of SNP polymorphisms of EDN1, EDNRA, and EDNRB gene on ischemic stroke. Cell Biochem Biophys. 2014;70(1):233-9.
Zhang, L., & Sui, R. (2014). Effect of SNP polymorphisms of EDN1, EDNRA, and EDNRB gene on ischemic stroke. Cell Biochemistry and Biophysics, 70(1), 233-9. https://doi.org/10.1007/s12013-014-9887-6
Zhang L, Sui R. Effect of SNP Polymorphisms of EDN1, EDNRA, and EDNRB Gene On Ischemic Stroke. Cell Biochem Biophys. 2014;70(1):233-9. PubMed PMID: 24633486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of SNP polymorphisms of EDN1, EDNRA, and EDNRB gene on ischemic stroke. AU - Zhang,Lei, AU - Sui,Rubo, PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2015/9/4/medline SP - 233 EP - 9 JF - Cell biochemistry and biophysics JO - Cell Biochem Biophys VL - 70 IS - 1 N2 - The objective of this study is to investigate the association between SNP polymorphisms of endothelin-1 (EDN1) and endothelin receptor (EDNRA and EDNRB) gene and ischemic stroke (IS) in the Chinese Han population in northern. A case-control study was introduced. We genotyped eight SNPs (rs1800541, rs2070699, and rs5370 in EDN1 gene; rs1801708, rs5333, and rs5335 in EDNRA gene; and rs3818416 and rs5351 in EDNRB gene) and calculated their polymorphic distribution in control group, IS group, and the IS subgroups. In male population, EDN1 gene rs2070699 G allele increased the incidence risk to 1.78 times (P = 0.009; OR 1.78; 95 % CI 1.15-2.75) and the risk of morbidity of rs5370 T allele carrying increased to 1.49 times (P = 0.048; OR 1.49; 95 % CI 1.00-2.21). EDNRA gene mutation rs5335 homozygous CC morbidity risk was significantly lower (P = 0.016; OR 0.52; 95 % CI 0.31-0.88). In the female population, the mutant homozygous AA cancer risk was significantly higher than G allele carriers (P = 0.019; OR 2.65; 95 % CI 1.18-6.00) on EDNRA gene rs1801708. In EDN1 gene, T allele of rs5370 and G allele of rs2070699 may be IS incidence risk factors in Northern Han male population. A allele of rs1801708 in EDNRA gene can increase the risk of IS in Northern Han women population. SN - 1559-0283 UR - https://www.unboundmedicine.com/medline/citation/24633486/Effect_of_SNP_polymorphisms_of_EDN1_EDNRA_and_EDNRB_gene_on_ischemic_stroke_ L2 - https://dx.doi.org/10.1007/s12013-014-9887-6 DB - PRIME DP - Unbound Medicine ER -