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Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity.
Eur J Epidemiol. 2014 Apr; 29(4):285-92.EJ

Abstract

The risk factors for Parkinson's disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973-1976. The study population comprised 6,715 men and women aged 50-79 years and free of PD at the baseline. All of the subjects completed a baseline health examination (including height and weight measurements) and a questionnaire providing information on leisure-time physical activity, smoking, and alcohol consumption. During a 22-year follow-up, 101 incident cases of PD occurred. The statistical analyses were based on Cox's model including age, sex, education, community density, occupation, coffee consumption, body mass index (BMI), leisure-time physical activity, smoking and alcohol consumption as independent variables. At first, BMI was not associated with PD risk, but after exclusion of the first 15 years of follow-up, an elevated risk appeared at higher BMI levels (P for trend 0.02). Furthermore, subjects with heavy leisure-time physical activity had a lower PD risk than those with no activity [relative risk (RR) 0.27, 95 % confidence interval (CI) 0.08-0.90]. In variance with findings for other chronic diseases, current smokers had a lower PD risk than those who had never smoked (RR 0.23, 95 % CI 0.08-0.67), and individuals with moderate alcohol intake (at the level of <5 g/day) had an elevated PD risk compared to non-drinkers. The results support the hypothesis that lifestyle factors predict the occurrence of Parkinson's disease, but more research is needed.

Authors+Show Affiliations

Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24633681

Citation

Sääksjärvi, Katri, et al. "Reduced Risk of Parkinson's Disease Associated With Lower Body Mass Index and Heavy Leisure-time Physical Activity." European Journal of Epidemiology, vol. 29, no. 4, 2014, pp. 285-92.
Sääksjärvi K, Knekt P, Männistö S, et al. Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity. Eur J Epidemiol. 2014;29(4):285-92.
Sääksjärvi, K., Knekt, P., Männistö, S., Lyytinen, J., Jääskeläinen, T., Kanerva, N., & Heliövaara, M. (2014). Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity. European Journal of Epidemiology, 29(4), 285-92. https://doi.org/10.1007/s10654-014-9887-2
Sääksjärvi K, et al. Reduced Risk of Parkinson's Disease Associated With Lower Body Mass Index and Heavy Leisure-time Physical Activity. Eur J Epidemiol. 2014;29(4):285-92. PubMed PMID: 24633681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity. AU - Sääksjärvi,Katri, AU - Knekt,Paul, AU - Männistö,Satu, AU - Lyytinen,Jukka, AU - Jääskeläinen,Tuija, AU - Kanerva,Noora, AU - Heliövaara,Markku, Y1 - 2014/03/16/ PY - 2013/06/14/received PY - 2014/02/26/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2014/7/8/medline SP - 285 EP - 92 JF - European journal of epidemiology JO - Eur J Epidemiol VL - 29 IS - 4 N2 - The risk factors for Parkinson's disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973-1976. The study population comprised 6,715 men and women aged 50-79 years and free of PD at the baseline. All of the subjects completed a baseline health examination (including height and weight measurements) and a questionnaire providing information on leisure-time physical activity, smoking, and alcohol consumption. During a 22-year follow-up, 101 incident cases of PD occurred. The statistical analyses were based on Cox's model including age, sex, education, community density, occupation, coffee consumption, body mass index (BMI), leisure-time physical activity, smoking and alcohol consumption as independent variables. At first, BMI was not associated with PD risk, but after exclusion of the first 15 years of follow-up, an elevated risk appeared at higher BMI levels (P for trend 0.02). Furthermore, subjects with heavy leisure-time physical activity had a lower PD risk than those with no activity [relative risk (RR) 0.27, 95 % confidence interval (CI) 0.08-0.90]. In variance with findings for other chronic diseases, current smokers had a lower PD risk than those who had never smoked (RR 0.23, 95 % CI 0.08-0.67), and individuals with moderate alcohol intake (at the level of <5 g/day) had an elevated PD risk compared to non-drinkers. The results support the hypothesis that lifestyle factors predict the occurrence of Parkinson's disease, but more research is needed. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/24633681/Reduced_risk_of_Parkinson's_disease_associated_with_lower_body_mass_index_and_heavy_leisure_time_physical_activity_ L2 - https://doi.org/10.1007/s10654-014-9887-2 DB - PRIME DP - Unbound Medicine ER -