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Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The Vent-HeFT trial: a European prospective multicentre randomized trial.
Eur J Heart Fail 2014; 16(5):574-82EJ

Abstract

AIMS

Vent-HeFT is a multicentre randomized trial designed to investigate the potential additive benefits of inspiratory muscle training (IMT) on aerobic training (AT) in patients with chronic heart failure (CHF).

METHODS AND RESULTS

Forty-three CHF patients with a mean age of 58 ± 12 years, peak oxygen consumption (peak VO2) 17.9 ± 5 mL/kg/min, and LVEF 29.5 ± 5% were randomized to an AT/IMT group (n = 21) or to an AT/SHAM group (n = 22) in a 12-week exercise programme. AT involved 45 min of ergometer training at 70-80% of maximum heart rate, three times a week for both groups. In the AT/IMT group, IMT was performed at 60% of sustained maximal inspiratory pressure (SPImax) while in the AT/SHAM group it was performed at 10% of SPImax , using a computer biofeedback trainer for 30 min, three times a week. At baseline and at 3 months, patients were evaluated for exercise capacity, lung function, inspiratory muscle strength (PImax) and work capacity (SPImax), quality of life (QoL), LVEF and LV diameter, dyspnoea, C-reactive protein (CRP), and NT-proBNP. IMT resulted in a significantly higher benefit in SPImax (P = 0.02), QoL (P = 0.002), dyspnoea (P = 0.004), CRP (P = 0.03), and NT-proBNP (P = 0.004). In both AT/IMT and AT/SHAM groups PImax (P < 0.001, P = 0.02), peak VO2 (P = 0.008, P = 0.04), and LVEF (P = 0.005, P = 0.002) improved significantly; however, without an additional benefit for either of the groups.

CONCLUSION

This randomized multicentre study demonstrates that IMT combined with aerobic training provides additional benefits in functional and serum biomarkers in patients with moderate CHF. These findings advocate for application of IMT in cardiac rehabilitation programmes.

Authors+Show Affiliations

Heart Failure Unit, Stress Testing & Rehabilitation, Onassis Cardiac Surgery Center, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

24634346

Citation

Adamopoulos, Stamatis, et al. "Combined Aerobic/inspiratory Muscle Training Vs. Aerobic Training in Patients With Chronic Heart Failure: the Vent-HeFT Trial: a European Prospective Multicentre Randomized Trial." European Journal of Heart Failure, vol. 16, no. 5, 2014, pp. 574-82.
Adamopoulos S, Schmid JP, Dendale P, et al. Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The Vent-HeFT trial: a European prospective multicentre randomized trial. Eur J Heart Fail. 2014;16(5):574-82.
Adamopoulos, S., Schmid, J. P., Dendale, P., Poerschke, D., Hansen, D., Dritsas, A., ... Laoutaris, I. D. (2014). Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The Vent-HeFT trial: a European prospective multicentre randomized trial. European Journal of Heart Failure, 16(5), pp. 574-82. doi:10.1002/ejhf.70.
Adamopoulos S, et al. Combined Aerobic/inspiratory Muscle Training Vs. Aerobic Training in Patients With Chronic Heart Failure: the Vent-HeFT Trial: a European Prospective Multicentre Randomized Trial. Eur J Heart Fail. 2014;16(5):574-82. PubMed PMID: 24634346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The Vent-HeFT trial: a European prospective multicentre randomized trial. AU - Adamopoulos,Stamatis, AU - Schmid,Jean-Paul, AU - Dendale,Paul, AU - Poerschke,Daniel, AU - Hansen,Dominique, AU - Dritsas,Athanasios, AU - Kouloubinis,Alexandros, AU - Alders,Toon, AU - Gkouziouta,Aggeliki, AU - Reyckers,Ilse, AU - Vartela,Vasiliki, AU - Plessas,Nikos, AU - Doulaptsis,Costas, AU - Saner,Hugo, AU - Laoutaris,Ioannis D, Y1 - 2014/03/14/ PY - 2013/10/01/received PY - 2013/12/19/revised PY - 2014/01/03/accepted PY - 2014/3/18/entrez PY - 2014/3/19/pubmed PY - 2015/4/11/medline KW - Aerobic training KW - Chronic heart failure KW - Exercise KW - Inspiratory muscle training KW - Quality of life KW - Rehabilitation KW - Vent-HeFT trial SP - 574 EP - 82 JF - European journal of heart failure JO - Eur. J. Heart Fail. VL - 16 IS - 5 N2 - AIMS: Vent-HeFT is a multicentre randomized trial designed to investigate the potential additive benefits of inspiratory muscle training (IMT) on aerobic training (AT) in patients with chronic heart failure (CHF). METHODS AND RESULTS: Forty-three CHF patients with a mean age of 58 ± 12 years, peak oxygen consumption (peak VO2) 17.9 ± 5 mL/kg/min, and LVEF 29.5 ± 5% were randomized to an AT/IMT group (n = 21) or to an AT/SHAM group (n = 22) in a 12-week exercise programme. AT involved 45 min of ergometer training at 70-80% of maximum heart rate, three times a week for both groups. In the AT/IMT group, IMT was performed at 60% of sustained maximal inspiratory pressure (SPImax) while in the AT/SHAM group it was performed at 10% of SPImax , using a computer biofeedback trainer for 30 min, three times a week. At baseline and at 3 months, patients were evaluated for exercise capacity, lung function, inspiratory muscle strength (PImax) and work capacity (SPImax), quality of life (QoL), LVEF and LV diameter, dyspnoea, C-reactive protein (CRP), and NT-proBNP. IMT resulted in a significantly higher benefit in SPImax (P = 0.02), QoL (P = 0.002), dyspnoea (P = 0.004), CRP (P = 0.03), and NT-proBNP (P = 0.004). In both AT/IMT and AT/SHAM groups PImax (P < 0.001, P = 0.02), peak VO2 (P = 0.008, P = 0.04), and LVEF (P = 0.005, P = 0.002) improved significantly; however, without an additional benefit for either of the groups. CONCLUSION: This randomized multicentre study demonstrates that IMT combined with aerobic training provides additional benefits in functional and serum biomarkers in patients with moderate CHF. These findings advocate for application of IMT in cardiac rehabilitation programmes. SN - 1879-0844 UR - https://www.unboundmedicine.com/medline/citation/24634346/Combined_aerobic/inspiratory_muscle_training_vs__aerobic_training_in_patients_with_chronic_heart_failure:_The_Vent_HeFT_trial:_a_European_prospective_multicentre_randomized_trial_ L2 - https://doi.org/10.1002/ejhf.70 DB - PRIME DP - Unbound Medicine ER -