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Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease.
J Am Geriatr Soc. 2014 Apr; 62(4):679-84.JA

Abstract

OBJECTIVES

To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).

DESIGN

Retrospective chart review.

SETTING

Community-based memory clinic.

PARTICIPANTS

Individuals meeting Petersen's MCI criteria (N = 165).

MEASUREMENTS

Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.

RESULTS

One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%).

CONCLUSION

Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.

Authors+Show Affiliations

Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada; Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24635004

Citation

Julayanont, Parunyou, et al. "Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease." Journal of the American Geriatrics Society, vol. 62, no. 4, 2014, pp. 679-84.
Julayanont P, Brousseau M, Chertkow H, et al. Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease. J Am Geriatr Soc. 2014;62(4):679-84.
Julayanont, P., Brousseau, M., Chertkow, H., Phillips, N., & Nasreddine, Z. S. (2014). Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease. Journal of the American Geriatrics Society, 62(4), 679-84. https://doi.org/10.1111/jgs.12742
Julayanont P, et al. Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease. J Am Geriatr Soc. 2014;62(4):679-84. PubMed PMID: 24635004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease. AU - Julayanont,Parunyou, AU - Brousseau,Mélanie, AU - Chertkow,Howard, AU - Phillips,Natalie, AU - Nasreddine,Ziad S, Y1 - 2014/03/17/ PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2014/6/4/medline KW - Alzheimer KW - Memory Index Score KW - Montreal Cognitive Assessment KW - mild cognitive impairment SP - 679 EP - 84 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 62 IS - 4 N2 - OBJECTIVES: To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). DESIGN: Retrospective chart review. SETTING: Community-based memory clinic. PARTICIPANTS: Individuals meeting Petersen's MCI criteria (N = 165). MEASUREMENTS: Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD. RESULTS: One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%). CONCLUSION: Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/24635004/Montreal_Cognitive_Assessment_Memory_Index_Score__MoCA_MIS__as_a_predictor_of_conversion_from_mild_cognitive_impairment_to_Alzheimer's_disease_ L2 - https://doi.org/10.1111/jgs.12742 DB - PRIME DP - Unbound Medicine ER -