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Gastroprotective effect of standardized leaf extract from Careya arborea on experimental gastric ulcers in rats.
Pharm Biol. 2014 Aug; 52(8):1003-8.PB

Abstract

CONTEXT

The leaf of Careya arborea Roxb. (Lecthidaceae) has been advocated in Ayurveda for the treatment of various disorders, including ulcers, healing of wounds and several skin diseases.

OBJECTIVE

The 70% ethanol (EtOH) extract of C. arborea leaves (CALE) was investigated for its gastroprotective effect in different gastric ulcer models.

MATERIALS AND METHODS

CALE (100, 200, and 400 mg/kg body weight) was administered orally, twice daily for 5 d, for preventing aspirin (ASP)-, EtOH-, pylorus ligation (PL)-, and cold restraint stress (CRS)-induced ulcer in rats. The status of the antioxidant enzymes in CRS-induced ulcers, H(+)K(+)ATPase activity, gastric wall mucous in EtOH-induced ulcer, and gastric secretion parameters were estimated in the PL-induced ulcer model.

RESULTS

CALE exhibited significant (p < 0.01) dose-dependent inhibition of ulcer index in ASP 12.90-51.61%, EtOH 11.97-40.35%, PL 28.63-63.92%, and CRS 38.30-66.37%, respectively. A significant (p < 0.001) decrease occurred in the level of H(+)K(+)ATPase, volume of gastric juice, and acid output. Simultaneously, the level of gastric wall mucus was increased significantly (p < 0.05). The antioxidant enzyme levels of LPO and SOD were decreased with concomitant increase in catalase activity in CRS-induced ulcers. High-performance thin-layer chromatography (HPTLC) showed the presence of quercetin, ellagic acid, and gallic acid (0.31%, 0.24%, and 0.71% w/w, respectively) in CALE.

CONCLUSIONS

Our results show that C. arborea possesses significant gastro-protective activity, probably due to its free radical scavenging activity, and validate the folklore claim.

Authors+Show Affiliations

Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University , Kanpur, Uttar Pradesh , India and.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24635213

Citation

Gupta, Prakash Chandra, and Chandana V. Rao. "Gastroprotective Effect of Standardized Leaf Extract From Careya Arborea On Experimental Gastric Ulcers in Rats." Pharmaceutical Biology, vol. 52, no. 8, 2014, pp. 1003-8.
Gupta PC, Rao CV. Gastroprotective effect of standardized leaf extract from Careya arborea on experimental gastric ulcers in rats. Pharm Biol. 2014;52(8):1003-8.
Gupta, P. C., & Rao, C. V. (2014). Gastroprotective effect of standardized leaf extract from Careya arborea on experimental gastric ulcers in rats. Pharmaceutical Biology, 52(8), 1003-8. https://doi.org/10.3109/13880209.2013.876052
Gupta PC, Rao CV. Gastroprotective Effect of Standardized Leaf Extract From Careya Arborea On Experimental Gastric Ulcers in Rats. Pharm Biol. 2014;52(8):1003-8. PubMed PMID: 24635213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective effect of standardized leaf extract from Careya arborea on experimental gastric ulcers in rats. AU - Gupta,Prakash Chandra, AU - Rao,Chandana V, Y1 - 2014/03/17/ PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2015/3/31/medline KW - Antioxidant KW - free radicals KW - phenolics KW - reactive oxygen species KW - superoxide dismutase SP - 1003 EP - 8 JF - Pharmaceutical biology JO - Pharm Biol VL - 52 IS - 8 N2 - CONTEXT: The leaf of Careya arborea Roxb. (Lecthidaceae) has been advocated in Ayurveda for the treatment of various disorders, including ulcers, healing of wounds and several skin diseases. OBJECTIVE: The 70% ethanol (EtOH) extract of C. arborea leaves (CALE) was investigated for its gastroprotective effect in different gastric ulcer models. MATERIALS AND METHODS: CALE (100, 200, and 400 mg/kg body weight) was administered orally, twice daily for 5 d, for preventing aspirin (ASP)-, EtOH-, pylorus ligation (PL)-, and cold restraint stress (CRS)-induced ulcer in rats. The status of the antioxidant enzymes in CRS-induced ulcers, H(+)K(+)ATPase activity, gastric wall mucous in EtOH-induced ulcer, and gastric secretion parameters were estimated in the PL-induced ulcer model. RESULTS: CALE exhibited significant (p < 0.01) dose-dependent inhibition of ulcer index in ASP 12.90-51.61%, EtOH 11.97-40.35%, PL 28.63-63.92%, and CRS 38.30-66.37%, respectively. A significant (p < 0.001) decrease occurred in the level of H(+)K(+)ATPase, volume of gastric juice, and acid output. Simultaneously, the level of gastric wall mucus was increased significantly (p < 0.05). The antioxidant enzyme levels of LPO and SOD were decreased with concomitant increase in catalase activity in CRS-induced ulcers. High-performance thin-layer chromatography (HPTLC) showed the presence of quercetin, ellagic acid, and gallic acid (0.31%, 0.24%, and 0.71% w/w, respectively) in CALE. CONCLUSIONS: Our results show that C. arborea possesses significant gastro-protective activity, probably due to its free radical scavenging activity, and validate the folklore claim. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/24635213/Gastroprotective_effect_of_standardized_leaf_extract_from_Careya_arborea_on_experimental_gastric_ulcers_in_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2013.876052 DB - PRIME DP - Unbound Medicine ER -