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Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics.
Antioxid Redox Signal. 2015 Feb 10; 22(5):398-410.AR

Abstract

SIGNIFICANCE

There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair. There is also growing evidence that H2S can be successfully exploited in drug development.

RECENT ADVANCES

H2S synthesis and degradation are regulated in circumstances of inflammation and injury so as to promote repair and re-establish homeostasis. Novel H2S-releasing drugs exhibit enhanced anti-inflammatory and pro-restorative effects, while having reduced adverse effects in many tissues.

CRITICAL ISSUES

H2S is a pleiotropic mediator, having effects on many elements in the inflammatory cascade and promoting the resolution of inflammation and injury. It also contributes significantly to mucosal defence in the gastrointestinal tract, and in host defence against infection. There is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models, and several are progressing through human trials.

FUTURE DIRECTIONS

A better understanding of the physiological and pathophysiological roles of H2S continues to be restrained by the lack of simple, reliable methods for measurement of H2S synthesis, and the paucity of highly selective inhibitors of enzymes that participate in endogenous H2S synthesis. On the other hand, H2S donors show promise as therapeutics for several important indications.

Authors+Show Affiliations

1 Department of Physiology & Pharmacology, University of Calgary , Calgary, Canada .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24635322

Citation

Wallace, John L., et al. "Anti-inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics." Antioxidants & Redox Signaling, vol. 22, no. 5, 2015, pp. 398-410.
Wallace JL, Blackler RW, Chan MV, et al. Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics. Antioxid Redox Signal. 2015;22(5):398-410.
Wallace, J. L., Blackler, R. W., Chan, M. V., Da Silva, G. J., Elsheikh, W., Flannigan, K. L., Gamaniek, I., Manko, A., Wang, L., Motta, J. P., & Buret, A. G. (2015). Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics. Antioxidants & Redox Signaling, 22(5), 398-410. https://doi.org/10.1089/ars.2014.5901
Wallace JL, et al. Anti-inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics. Antioxid Redox Signal. 2015 Feb 10;22(5):398-410. PubMed PMID: 24635322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics. AU - Wallace,John L, AU - Blackler,Rory W, AU - Chan,Melissa V, AU - Da Silva,Gabriela J, AU - Elsheikh,Wagdi, AU - Flannigan,Kyle L, AU - Gamaniek,Iulia, AU - Manko,Anna, AU - Wang,Lu, AU - Motta,Jean-Paul, AU - Buret,Andre G, Y1 - 2014/04/15/ PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2015/11/18/medline SP - 398 EP - 410 JF - Antioxidants & redox signaling JO - Antioxid. Redox Signal. VL - 22 IS - 5 N2 - SIGNIFICANCE: There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair. There is also growing evidence that H2S can be successfully exploited in drug development. RECENT ADVANCES: H2S synthesis and degradation are regulated in circumstances of inflammation and injury so as to promote repair and re-establish homeostasis. Novel H2S-releasing drugs exhibit enhanced anti-inflammatory and pro-restorative effects, while having reduced adverse effects in many tissues. CRITICAL ISSUES: H2S is a pleiotropic mediator, having effects on many elements in the inflammatory cascade and promoting the resolution of inflammation and injury. It also contributes significantly to mucosal defence in the gastrointestinal tract, and in host defence against infection. There is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models, and several are progressing through human trials. FUTURE DIRECTIONS: A better understanding of the physiological and pathophysiological roles of H2S continues to be restrained by the lack of simple, reliable methods for measurement of H2S synthesis, and the paucity of highly selective inhibitors of enzymes that participate in endogenous H2S synthesis. On the other hand, H2S donors show promise as therapeutics for several important indications. SN - 1557-7716 UR - https://www.unboundmedicine.com/medline/citation/24635322/Anti_inflammatory_and_cytoprotective_actions_of_hydrogen_sulfide:_translation_to_therapeutics_ L2 - https://www.liebertpub.com/doi/full/10.1089/ars.2014.5901?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -