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Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study.
J Am Geriatr Soc. 2014 Apr; 62(4):636-41.JA

Abstract

OBJECTIVES

To examine the relationship between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance over time in older adults in the Health, Aging and Body Composition (Health ABC) Study.

DESIGN

Prospective cohort study.

SETTING

Community-dwelling participants in Pittsburgh, Pennsylvania, and Memphis, Tennessee.

PARTICIPANTS

Well-functioning adults aged 70 to 79 at baseline with serum 25(OH)D measured at the 12-month follow-up visit and cognitive function measured at baseline and 4-year follow-up visit (N = 2,777).

MEASUREMENTS

Vitamin D status was categorized as 25(OH)D levels of less than 20.0 ng/mL, 20.0 to 29.9 ng/mL, or 30.0 ng/mL or greater. Cognition was measured using the modified Mini-Mental State Examination (3MS) and Digit Symbol Substitution Test (DSST). Linear regression models adjusting for multiple covariates, including age, education, sex, race, site, season, physical activity, and comorbidities, were used in the analysis.

RESULTS

Sixty-eight percent of participants had 25(OH)D levels of less than 30.0 ng/mL. Lower 25(OH)D levels were associated with lower baseline cognitive scores on the 3MS (adjusted mean 89.9, 95% confidence interval (CI) = 89.4-90.4 for <20.0 ng/mL; adjusted mean 90.8, 95% CI = 90.4-91.3 for 20.0-29.9 ng/mL; adjusted mean 90.6, 95% CI = 90.2-91.1 for ≥ 30.0 ng/mL; P trend = .02) and the DSST (adjusted mean 35.2, 95% CI = 34.5-36.0 for <20.0 ng/mL; adjusted mean 35.9, 95% CI = 35.2-36.6 for 20.0-29.9 ng/mL; adjusted mean 37.0, 95% CI = 36.3-37.8 for ≥ 30.0 ng/mL; P trend = .01). Participants with low 25(OH)D levels had greater declines in 3MS scores over 4 years than those with higher levels (least square mean change -1.0, 95% CI = -1.5 to -0.6 for <20.0 ng/mL; least square mean change -0.8, 95% CI = -1.2 to -0.3 for 20.0-29.9 ng/mL; least square mean change -0.2, 95% CI = -0.7 to 0.2 for ≥30.0 ng/mL; P = .05). There was no significant difference in DSST decline according to 25(OH)D level.

CONCLUSION

Low 25(OH)D levels were associated with worse global cognitive function and greater decline over time according to the 3MS. Intervention trials are needed to determine whether vitamin D supplementation can reduce cognitive decline.

Authors+Show Affiliations

Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

24635412

Citation

Wilson, Valerie K., et al. "Relationship Between 25-hydroxyvitamin D and Cognitive Function in Older Adults: the Health, Aging and Body Composition Study." Journal of the American Geriatrics Society, vol. 62, no. 4, 2014, pp. 636-41.
Wilson VK, Houston DK, Kilpatrick L, et al. Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2014;62(4):636-41.
Wilson, V. K., Houston, D. K., Kilpatrick, L., Lovato, J., Yaffe, K., Cauley, J. A., Harris, T. B., Simonsick, E. M., Ayonayon, H. N., Kritchevsky, S. B., & Sink, K. M. (2014). Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society, 62(4), 636-41. https://doi.org/10.1111/jgs.12765
Wilson VK, et al. Relationship Between 25-hydroxyvitamin D and Cognitive Function in Older Adults: the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2014;62(4):636-41. PubMed PMID: 24635412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between 25-hydroxyvitamin D and cognitive function in older adults: the Health, Aging and Body Composition Study. AU - Wilson,Valerie K, AU - Houston,Denise K, AU - Kilpatrick,Laurel, AU - Lovato,James, AU - Yaffe,Kristine, AU - Cauley,Jane A, AU - Harris,Tamara B, AU - Simonsick,Eleanor M, AU - Ayonayon,Hilsa N, AU - Kritchevsky,Stephen B, AU - Sink,Kaycee M, AU - ,, Y1 - 2014/03/17/ PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2014/6/4/medline KW - cognition KW - cognitive function KW - memory KW - vitamin D SP - 636 EP - 41 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 62 IS - 4 N2 - OBJECTIVES: To examine the relationship between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance over time in older adults in the Health, Aging and Body Composition (Health ABC) Study. DESIGN: Prospective cohort study. SETTING: Community-dwelling participants in Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Well-functioning adults aged 70 to 79 at baseline with serum 25(OH)D measured at the 12-month follow-up visit and cognitive function measured at baseline and 4-year follow-up visit (N = 2,777). MEASUREMENTS: Vitamin D status was categorized as 25(OH)D levels of less than 20.0 ng/mL, 20.0 to 29.9 ng/mL, or 30.0 ng/mL or greater. Cognition was measured using the modified Mini-Mental State Examination (3MS) and Digit Symbol Substitution Test (DSST). Linear regression models adjusting for multiple covariates, including age, education, sex, race, site, season, physical activity, and comorbidities, were used in the analysis. RESULTS: Sixty-eight percent of participants had 25(OH)D levels of less than 30.0 ng/mL. Lower 25(OH)D levels were associated with lower baseline cognitive scores on the 3MS (adjusted mean 89.9, 95% confidence interval (CI) = 89.4-90.4 for <20.0 ng/mL; adjusted mean 90.8, 95% CI = 90.4-91.3 for 20.0-29.9 ng/mL; adjusted mean 90.6, 95% CI = 90.2-91.1 for ≥ 30.0 ng/mL; P trend = .02) and the DSST (adjusted mean 35.2, 95% CI = 34.5-36.0 for <20.0 ng/mL; adjusted mean 35.9, 95% CI = 35.2-36.6 for 20.0-29.9 ng/mL; adjusted mean 37.0, 95% CI = 36.3-37.8 for ≥ 30.0 ng/mL; P trend = .01). Participants with low 25(OH)D levels had greater declines in 3MS scores over 4 years than those with higher levels (least square mean change -1.0, 95% CI = -1.5 to -0.6 for <20.0 ng/mL; least square mean change -0.8, 95% CI = -1.2 to -0.3 for 20.0-29.9 ng/mL; least square mean change -0.2, 95% CI = -0.7 to 0.2 for ≥30.0 ng/mL; P = .05). There was no significant difference in DSST decline according to 25(OH)D level. CONCLUSION: Low 25(OH)D levels were associated with worse global cognitive function and greater decline over time according to the 3MS. Intervention trials are needed to determine whether vitamin D supplementation can reduce cognitive decline. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/24635412/Relationship_between_25_hydroxyvitamin_D_and_cognitive_function_in_older_adults:_the_Health_Aging_and_Body_Composition_Study_ L2 - https://doi.org/10.1111/jgs.12765 DB - PRIME DP - Unbound Medicine ER -