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The participation of varicella zoster virus in relapses of multiple sclerosis.
Clin Neurol Neurosurg 2014; 119:44-8CN

Abstract

OBJECTIVE

Recent studies have documented the apparent participation of varicella zoster virus (VZV) in the etiopathogenesis of multiple sclerosis (MS). The present study aimed to corroborate the possible presence of VZV during exacerbations of MS.

DESIGN

Fifty-three patients with definite MS were included; of them, 31 were studied during the first week of a clinical relapse, whereas 16 were studied during remission; 6 patients with progressive MS were also studied. Genes from 5 herpes viruses: varicella zoster, herpes simplex 1 and 2, Epstein-Barr and herpes 6 were studied by polymerase chain reaction in cerebrospinal fluid and in peripheral blood mononuclear cells (PBMC). As controls 21 patients with inflammatory or functional neurological disorders were included.

RESULTS

DNA from varicella zoster virus was found in the CSF from all MS patients studied during relapse (100%) and in the PBMC from 28 of them (90%). However, VZV DNA was found in the CSF only in 5 MS patients studied during remission (31%) and in the PBMC from 3 of them (19%). VZV DNA was also found, but in lower amounts, in the CSF (83%) and PBMC (33%) from patients with progressive MS. In contrast, VZV was not found either in CSF or in PBMC from controls. Results from the other herpes viruses tested were similar in MS patients and in controls.

CONCLUSIONS

Our results corroborate the conspicuous, but ephemeral presence of VZV during relapses of MS and support the idea of VZV involvement in the etiopathogenesis of MS. Recent epidemiological and molecular studies as well as reports of severe VZV infections triggered by specifically induced immunosuppression during therapy of MS give additional support to this potential association.

Authors+Show Affiliations

Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico. Electronic address: jsotelo@unam.mx.Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico.Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico.Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24635924

Citation

Sotelo, Julio, et al. "The Participation of Varicella Zoster Virus in Relapses of Multiple Sclerosis." Clinical Neurology and Neurosurgery, vol. 119, 2014, pp. 44-8.
Sotelo J, Ordoñez G, Pineda B, et al. The participation of varicella zoster virus in relapses of multiple sclerosis. Clin Neurol Neurosurg. 2014;119:44-8.
Sotelo, J., Ordoñez, G., Pineda, B., & Flores, J. (2014). The participation of varicella zoster virus in relapses of multiple sclerosis. Clinical Neurology and Neurosurgery, 119, pp. 44-8. doi:10.1016/j.clineuro.2013.12.020.
Sotelo J, et al. The Participation of Varicella Zoster Virus in Relapses of Multiple Sclerosis. Clin Neurol Neurosurg. 2014;119:44-8. PubMed PMID: 24635924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The participation of varicella zoster virus in relapses of multiple sclerosis. AU - Sotelo,Julio, AU - Ordoñez,Graciela, AU - Pineda,Benjamín, AU - Flores,José, Y1 - 2014/01/10/ PY - 2013/03/14/received PY - 2013/12/18/revised PY - 2013/12/25/accepted PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2014/11/6/medline KW - Fingolimod KW - Multiple sclerosis KW - Natalizumab KW - Varicella zoster virus KW - Virus and multiple sclerosis SP - 44 EP - 8 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 119 N2 - OBJECTIVE: Recent studies have documented the apparent participation of varicella zoster virus (VZV) in the etiopathogenesis of multiple sclerosis (MS). The present study aimed to corroborate the possible presence of VZV during exacerbations of MS. DESIGN: Fifty-three patients with definite MS were included; of them, 31 were studied during the first week of a clinical relapse, whereas 16 were studied during remission; 6 patients with progressive MS were also studied. Genes from 5 herpes viruses: varicella zoster, herpes simplex 1 and 2, Epstein-Barr and herpes 6 were studied by polymerase chain reaction in cerebrospinal fluid and in peripheral blood mononuclear cells (PBMC). As controls 21 patients with inflammatory or functional neurological disorders were included. RESULTS: DNA from varicella zoster virus was found in the CSF from all MS patients studied during relapse (100%) and in the PBMC from 28 of them (90%). However, VZV DNA was found in the CSF only in 5 MS patients studied during remission (31%) and in the PBMC from 3 of them (19%). VZV DNA was also found, but in lower amounts, in the CSF (83%) and PBMC (33%) from patients with progressive MS. In contrast, VZV was not found either in CSF or in PBMC from controls. Results from the other herpes viruses tested were similar in MS patients and in controls. CONCLUSIONS: Our results corroborate the conspicuous, but ephemeral presence of VZV during relapses of MS and support the idea of VZV involvement in the etiopathogenesis of MS. Recent epidemiological and molecular studies as well as reports of severe VZV infections triggered by specifically induced immunosuppression during therapy of MS give additional support to this potential association. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/24635924/The_participation_of_varicella_zoster_virus_in_relapses_of_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(14)00009-2 DB - PRIME DP - Unbound Medicine ER -