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[Aspergillus galactomannan assay for the management of histoplasmosis due to Histoplasma capsulatum var. duboisii in HIV-infected patients: education from a clinical case].
J Mycol Med. 2014 Jun; 24(2):166-70.JM

Abstract

The diagnosis of histoplasmosis due to Histoplasma capsulatum var capsulatum is based on a direct examination identifying encapsulated yeast with narrow-based budding. Galactomannan antigenemia facilitates diagnosis, as well as the monitoring of patients receiving treatment. The case of a HIV-positive patient from Congo-Brazzaville with a disseminated form of African histoplasmosis highlighted the positive galactomannan antigen in this disease due to Histoplasma capsulatum var duboisii. Galactomannan antigenemia remained high with a very slow decrease during antifungal therapy and slow regression of clinical lesions. African histoplasmosis is a rare disease that is difficult to diagnose and rarely described in immunocompromised patients, in whom differential diagnosis can be common. This observation underlines the importance of the galactomannan antigen assay in patients who have travelled to endemic areas. As in the case of Histoplasma capsulatum var capsulatum, the positivity of the Aspergillus galactomannan antigen is very useful in the diagnosis and monitoring of African histoplasmosis.

Authors+Show Affiliations

Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier de Versailles, 78150 Le Chesnay, France.Parasitologie, unité de microbiologie, département de biologie, hôpital André-Mignot, centre hospitalier de Versailles, 177, rue de Versailles, 78157 Le Chesnay, France.Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier de Versailles, 78150 Le Chesnay, France.Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier de Versailles, 78150 Le Chesnay, France.Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier de Versailles, 78150 Le Chesnay, France.Parasitologie, unité de microbiologie, département de biologie, hôpital André-Mignot, centre hospitalier de Versailles, 177, rue de Versailles, 78157 Le Chesnay, France. Electronic address: oeloy@ch-versailles.fr.

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

24636196

Citation

Therby, A, et al. "[Aspergillus Galactomannan Assay for the Management of Histoplasmosis Due to Histoplasma Capsulatum Var. Duboisii in HIV-infected Patients: Education From a Clinical Case]." Journal De Mycologie Medicale, vol. 24, no. 2, 2014, pp. 166-70.
Therby A, Polotzanu O, Khau D, et al. [Aspergillus galactomannan assay for the management of histoplasmosis due to Histoplasma capsulatum var. duboisii in HIV-infected patients: education from a clinical case]. J Mycol Med. 2014;24(2):166-70.
Therby, A., Polotzanu, O., Khau, D., Monnier, S., Greder Belan, A., & Eloy, O. (2014). [Aspergillus galactomannan assay for the management of histoplasmosis due to Histoplasma capsulatum var. duboisii in HIV-infected patients: education from a clinical case]. Journal De Mycologie Medicale, 24(2), 166-70. https://doi.org/10.1016/j.mycmed.2014.01.002
Therby A, et al. [Aspergillus Galactomannan Assay for the Management of Histoplasmosis Due to Histoplasma Capsulatum Var. Duboisii in HIV-infected Patients: Education From a Clinical Case]. J Mycol Med. 2014;24(2):166-70. PubMed PMID: 24636196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Aspergillus galactomannan assay for the management of histoplasmosis due to Histoplasma capsulatum var. duboisii in HIV-infected patients: education from a clinical case]. AU - Therby,A, AU - Polotzanu,O, AU - Khau,D, AU - Monnier,S, AU - Greder Belan,A, AU - Eloy,O, Y1 - 2014/03/11/ PY - 2013/10/15/received PY - 2013/12/06/revised PY - 2014/01/06/accepted PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2015/4/17/medline KW - African histoplasmosis KW - Galactomannan KW - Galactomannane KW - HIV KW - Histoplasma capsulatum var. duboisii KW - Histoplasmose africaine KW - VIH SP - 166 EP - 70 JF - Journal de mycologie medicale JO - J Mycol Med VL - 24 IS - 2 N2 - The diagnosis of histoplasmosis due to Histoplasma capsulatum var capsulatum is based on a direct examination identifying encapsulated yeast with narrow-based budding. Galactomannan antigenemia facilitates diagnosis, as well as the monitoring of patients receiving treatment. The case of a HIV-positive patient from Congo-Brazzaville with a disseminated form of African histoplasmosis highlighted the positive galactomannan antigen in this disease due to Histoplasma capsulatum var duboisii. Galactomannan antigenemia remained high with a very slow decrease during antifungal therapy and slow regression of clinical lesions. African histoplasmosis is a rare disease that is difficult to diagnose and rarely described in immunocompromised patients, in whom differential diagnosis can be common. This observation underlines the importance of the galactomannan antigen assay in patients who have travelled to endemic areas. As in the case of Histoplasma capsulatum var capsulatum, the positivity of the Aspergillus galactomannan antigen is very useful in the diagnosis and monitoring of African histoplasmosis. SN - 1773-0449 UR - https://www.unboundmedicine.com/medline/citation/24636196/[Aspergillus_galactomannan_assay_for_the_management_of_histoplasmosis_due_to_Histoplasma_capsulatum_var__duboisii_in_HIV_infected_patients:_education_from_a_clinical_case]_ DB - PRIME DP - Unbound Medicine ER -