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Alcohol consumption and survival after a breast cancer diagnosis: a literature-based meta-analysis and collaborative analysis of data for 29,239 cases.
Cancer Epidemiol Biomarkers Prev 2014; 23(6):934-45CE

Abstract

BACKGROUND

Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts.

METHODS

A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts.

RESULTS

We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease.

CONCLUSION

There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease.

IMPACT

Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer.

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    Authors+Show Affiliations

    Ali AM
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Schmidt MK
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Bolla MK
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Wang Q
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Gago-Dominguez M
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Castelao JE
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Carracedo A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Garzón VM
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Bojesen SE
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Nordestgaard BG
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Flyger H
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Chang-Claude J
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Vrieling A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Rudolph A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Seibold P
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Nevanlinna H
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Muranen TA
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Aaltonen K
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Blomqvist C
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Matsuo K
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Ito H
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Iwata H
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Horio A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    John EM
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Sherman M
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Lissowska J
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Figueroa J
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Garcia-Closas M
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Anton-Culver H
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Shah M
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Hopper JL
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Trichopoulou A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Bueno-de-Mesquita B
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Krogh V
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Weiderpass E
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Andersson A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Clavel-Chapelon F
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Dossus L
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Fagherazzi G
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Peeters PH
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Olsen A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Wishart GC
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Easton DF
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Borgquist S
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Overvad K
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Barricarte A
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    González CA
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Sánchez MJ
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Amiano P
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Riboli E
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Key T
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D
    Pharoah PD
    Authors' Affiliations: Department of Public Health and Primary Care, University of Cambridge; Department of Public Health and Primary Care and Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge; Faculty of Health, Social Care & Education, Anglia Ruskin University, Cambridge; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London; School of Public Health, Imperial College London, London; and Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics and Cancer Epidemiology, South Egypt Cancer Institute, Assiut, Egypt; Divisions of Psychosocial Research and Epidemiology and Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam; Department for Health Evidence, Radboud University Medical Centre, Nijmegen; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela; Oncology and Genetics Unit, University Hospital of Vigo, Galicia Health Service (SERGAS); Radiotherapy Department, University Hospital of Vigo, Vigo; Navarre Public Health Institute, Pamplona; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP); Chief Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona; Andalusian School of Public Health, Granada; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid; Public Health D

    MeSH

    AdultAgedAlcohol DrinkingBreast NeoplasmsCohort StudiesFemaleHumansMiddle AgedPrognosisRisk FactorsYoung Adult

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24636975

    Citation

    Ali, Alaa M G., et al. "Alcohol Consumption and Survival After a Breast Cancer Diagnosis: a Literature-based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 23, no. 6, 2014, pp. 934-45.
    Ali AM, Schmidt MK, Bolla MK, et al. Alcohol consumption and survival after a breast cancer diagnosis: a literature-based meta-analysis and collaborative analysis of data for 29,239 cases. Cancer Epidemiol Biomarkers Prev. 2014;23(6):934-45.
    Ali, A. M., Schmidt, M. K., Bolla, M. K., Wang, Q., Gago-Dominguez, M., Castelao, J. E., ... Pharoah, P. D. (2014). Alcohol consumption and survival after a breast cancer diagnosis: a literature-based meta-analysis and collaborative analysis of data for 29,239 cases. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 23(6), pp. 934-45. doi:10.1158/1055-9965.EPI-13-0901.
    Ali AM, et al. Alcohol Consumption and Survival After a Breast Cancer Diagnosis: a Literature-based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases. Cancer Epidemiol Biomarkers Prev. 2014;23(6):934-45. PubMed PMID: 24636975.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and survival after a breast cancer diagnosis: a literature-based meta-analysis and collaborative analysis of data for 29,239 cases. AU - Ali,Alaa M G, AU - Schmidt,Marjanka K, AU - Bolla,Manjeet K, AU - Wang,Qin, AU - Gago-Dominguez,M, AU - Castelao,J Esteban, AU - Carracedo,Angel, AU - Garzón,Victor Muñoz, AU - Bojesen,Stig E, AU - Nordestgaard,Børge G, AU - Flyger,Henrik, AU - Chang-Claude,Jenny, AU - Vrieling,Alina, AU - Rudolph,Anja, AU - Seibold,Petra, AU - Nevanlinna,Heli, AU - Muranen,Taru A, AU - Aaltonen,Kirsimari, AU - Blomqvist,Carl, AU - Matsuo,Keitaro, AU - Ito,Hidemi, AU - Iwata,Hiroji, AU - Horio,Akiyo, AU - John,Esther M, AU - Sherman,Mark, AU - Lissowska,Jolanta, AU - Figueroa,Jonine, AU - Garcia-Closas,Montserrat, AU - Anton-Culver,Hoda, AU - Shah,Mitul, AU - Hopper,John L, AU - Trichopoulou,Antonia, AU - Bueno-de-Mesquita,Bas, AU - Krogh,Vittorio, AU - Weiderpass,Elisabete, AU - Andersson,Anne, AU - Clavel-Chapelon,Françoise, AU - Dossus,Laure, AU - Fagherazzi,Guy, AU - Peeters,Petra H, AU - Olsen,Anja, AU - Wishart,Gordon C, AU - Easton,Douglas F, AU - Borgquist,Signe, AU - Overvad,Kim, AU - Barricarte,Aurelio, AU - González,Carlos A, AU - Sánchez,María-José, AU - Amiano,Pilar, AU - Riboli,Elio, AU - Key,Tim, AU - Pharoah,Paul D, Y1 - 2014/03/17/ PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2016/5/18/medline SP - 934 EP - 45 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 23 IS - 6 N2 - BACKGROUND: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. METHODS: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. RESULTS: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. CONCLUSION: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. IMPACT: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/24636975/Alcohol_consumption_and_survival_after_a_breast_cancer_diagnosis:_a_literature_based_meta_analysis_and_collaborative_analysis_of_data_for_29239_cases_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=24636975 DB - PRIME DP - Unbound Medicine ER -