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Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin.
Acta Dermatovenerol Alp Pannonica Adriat. 2014 Mar; 23(1):1-3.AD

Abstract

BACKGROUND

The number of new syphilis diagnoses in Slovenia is steadily increasing, especially among HIV-infected men who have sex with men (MSM). We studied the effect of penicillin for treating syphilis in HIV co-infected patients and risk factors for treatment failure. The primary endpoint was response to therapy (fourfold reduction of VDRL at month 12).

METHODS

Three hundred forty-two paper records were reviewed and MSM with positive VDRL and/or TPHA and serological follow up of at least 12 months were enrolled in the survey.

RESULTS

Incidence of syphilis increased from 1.2% (2005) and 2.9% (2007) to 6.4% (2009) and 3.8% (2011, until July). Two hundred sixty-one (76.3%) were MSM and 102 (29.8%) were co-infected; 54.0% had primary/secondary syphilis, 37.0% latent syphilis, and 9.0% neurosyphilis. Patients with primary/secondary/latent syphilis were treated with three doses of benzathine penicillin (2.4 MU i.m.). Treatment was successful in 92.2%. With respect to risk factors, there was no difference between the "success" and "failure" group. Twenty-six patients (25.5%) had re-infections.

CONCLUSIONS

The rate of cure in our study population was excellent, probably due to a low degree of immunosuppression and a three-dose benzathine penicillin regimen.

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Authors+Show Affiliations

Saje A
Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana, Ljubljana, Slovenia. Corresponding author: sajecka@gmail.com.
Tomažič J
Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana, Ljubljana, Slovenia.

MeSH

AdultAnti-Bacterial AgentsCoinfectionHIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedPenicillin G BenzathineRetrospective StudiesRisk FactorsSloveniaSyphilisTreatment Failure

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24638864

Citation

Saje, Andreja, and Janez Tomažič. "Syphilis and HIV Co-infection: Excellent Response to Multiple Doses of Benzathine Penicillin." Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, vol. 23, no. 1, 2014, pp. 1-3.
Saje A, Tomažič J. Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin. Acta Dermatovenerol Alp Pannonica Adriat. 2014;23(1):1-3.
Saje, A., & Tomažič, J. (2014). Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin. Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, 23(1), 1-3.
Saje A, Tomažič J. Syphilis and HIV Co-infection: Excellent Response to Multiple Doses of Benzathine Penicillin. Acta Dermatovenerol Alp Pannonica Adriat. 2014;23(1):1-3. PubMed PMID: 24638864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin. AU - Saje,Andreja, AU - Tomažič,Janez, PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2015/2/3/medline SP - 1 EP - 3 JF - Acta dermatovenerologica Alpina, Pannonica, et Adriatica JO - Acta Dermatovenerol Alp Pannonica Adriat VL - 23 IS - 1 N2 - BACKGROUND: The number of new syphilis diagnoses in Slovenia is steadily increasing, especially among HIV-infected men who have sex with men (MSM). We studied the effect of penicillin for treating syphilis in HIV co-infected patients and risk factors for treatment failure. The primary endpoint was response to therapy (fourfold reduction of VDRL at month 12). METHODS: Three hundred forty-two paper records were reviewed and MSM with positive VDRL and/or TPHA and serological follow up of at least 12 months were enrolled in the survey. RESULTS: Incidence of syphilis increased from 1.2% (2005) and 2.9% (2007) to 6.4% (2009) and 3.8% (2011, until July). Two hundred sixty-one (76.3%) were MSM and 102 (29.8%) were co-infected; 54.0% had primary/secondary syphilis, 37.0% latent syphilis, and 9.0% neurosyphilis. Patients with primary/secondary/latent syphilis were treated with three doses of benzathine penicillin (2.4 MU i.m.). Treatment was successful in 92.2%. With respect to risk factors, there was no difference between the "success" and "failure" group. Twenty-six patients (25.5%) had re-infections. CONCLUSIONS: The rate of cure in our study population was excellent, probably due to a low degree of immunosuppression and a three-dose benzathine penicillin regimen. SN - 1581-2979 UR - https://www.unboundmedicine.com/medline/citation/24638864/Syphilis_and_HIV_co_infection:_excellent_response_to_multiple_doses_of_benzathine_penicillin_ L2 - https://s3-eu-west-1.amazonaws.com/thejournalhub/10.15570/v10162-012-0045-9/v10162-012-0045-9.pdf DB - PRIME DP - Unbound Medicine ER -