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Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin.

Abstract

BACKGROUND

The number of new syphilis diagnoses in Slovenia is steadily increasing, especially among HIV-infected men who have sex with men (MSM). We studied the effect of penicillin for treating syphilis in HIV co-infected patients and risk factors for treatment failure. The primary endpoint was response to therapy (fourfold reduction of VDRL at month 12).

METHODS

Three hundred forty-two paper records were reviewed and MSM with positive VDRL and/or TPHA and serological follow up of at least 12 months were enrolled in the survey.

RESULTS

Incidence of syphilis increased from 1.2% (2005) and 2.9% (2007) to 6.4% (2009) and 3.8% (2011, until July). Two hundred sixty-one (76.3%) were MSM and 102 (29.8%) were co-infected; 54.0% had primary/secondary syphilis, 37.0% latent syphilis, and 9.0% neurosyphilis. Patients with primary/secondary/latent syphilis were treated with three doses of benzathine penicillin (2.4 MU i.m.). Treatment was successful in 92.2%. With respect to risk factors, there was no difference between the "success" and "failure" group. Twenty-six patients (25.5%) had re-infections.

CONCLUSIONS

The rate of cure in our study population was excellent, probably due to a low degree of immunosuppression and a three-dose benzathine penicillin regimen.

Authors+Show Affiliations

Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana, Ljubljana, Slovenia. Corresponding author: sajecka@gmail.com.Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24638864

Citation

Saje, Andreja, and Janez Tomažič. "Syphilis and HIV Co-infection: Excellent Response to Multiple Doses of Benzathine Penicillin." Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, vol. 23, no. 1, 2014, pp. 1-3.
Saje A, Tomažič J. Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin. Acta Dermatovenerol Alp Pannonica Adriat. 2014;23(1):1-3.
Saje, A., & Tomažič, J. (2014). Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin. Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, 23(1), 1-3.
Saje A, Tomažič J. Syphilis and HIV Co-infection: Excellent Response to Multiple Doses of Benzathine Penicillin. Acta Dermatovenerol Alp Pannonica Adriat. 2014;23(1):1-3. PubMed PMID: 24638864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin. AU - Saje,Andreja, AU - Tomažič,Janez, PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2015/2/3/medline SP - 1 EP - 3 JF - Acta dermatovenerologica Alpina, Pannonica, et Adriatica JO - Acta Dermatovenerol Alp Pannonica Adriat VL - 23 IS - 1 N2 - BACKGROUND: The number of new syphilis diagnoses in Slovenia is steadily increasing, especially among HIV-infected men who have sex with men (MSM). We studied the effect of penicillin for treating syphilis in HIV co-infected patients and risk factors for treatment failure. The primary endpoint was response to therapy (fourfold reduction of VDRL at month 12). METHODS: Three hundred forty-two paper records were reviewed and MSM with positive VDRL and/or TPHA and serological follow up of at least 12 months were enrolled in the survey. RESULTS: Incidence of syphilis increased from 1.2% (2005) and 2.9% (2007) to 6.4% (2009) and 3.8% (2011, until July). Two hundred sixty-one (76.3%) were MSM and 102 (29.8%) were co-infected; 54.0% had primary/secondary syphilis, 37.0% latent syphilis, and 9.0% neurosyphilis. Patients with primary/secondary/latent syphilis were treated with three doses of benzathine penicillin (2.4 MU i.m.). Treatment was successful in 92.2%. With respect to risk factors, there was no difference between the "success" and "failure" group. Twenty-six patients (25.5%) had re-infections. CONCLUSIONS: The rate of cure in our study population was excellent, probably due to a low degree of immunosuppression and a three-dose benzathine penicillin regimen. SN - 1581-2979 UR - https://www.unboundmedicine.com/medline/citation/24638864/Syphilis_and_HIV_co_infection:_excellent_response_to_multiple_doses_of_benzathine_penicillin_ L2 - https://s3-eu-west-1.amazonaws.com/thejournalhub/10.15570/v10162-012-0045-9/v10162-012-0045-9.pdf DB - PRIME DP - Unbound Medicine ER -