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The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis.
J Endocrinol Invest. 2014 May; 37(5):473-6.JE

Abstract

BACKGROUND

Vitamin D is shown to be a potent immunomodulator. Considering the potential role of low serum vitamin D levels in autoimmune disorder, we evaluated the association between Hashimoto's thyroiditis (HT) (with subclinical or overt hypothyroidism) and serum 25-hydroxyvitamin D (25OHD) levels in an Iranian population.

METHODS

A total number of 86 individuals were enrolled. The case group included 41 patients with hypothyroid HT (overt or subclinical). The control group comprised 45 healthy euthyroid persons. Serum 25OHD levels were measured in all subjects.

THE CASE

control ratio of geometric means of 25OHD levels was 0.66 (95 % CI: 0.49-0.90; P = 0.008). There was a significant inverse association between serum 25OHD levels and HT (OR: 0.81 for 5 ng/ml increase in 25OHD level, 95 % CI: 0.68-0.96; P = 0.018). This association remained significant after adjustment for potential confounding factors including age, sex and BMI.

CONCLUSIONS

Our study suggested that higher serum 25OHD levels was associated with decreased risk of HT so that each 5 ng/ml increase in the serum 25OHD levels results in 19 % decrease in odds of HT.

Authors+Show Affiliations

Department of Endocrinology, AJA University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24639121

Citation

Mansournia, Nasrin, et al. "The Association Between Serum 25OHD Levels and Hypothyroid Hashimoto's Thyroiditis." Journal of Endocrinological Investigation, vol. 37, no. 5, 2014, pp. 473-6.
Mansournia N, Mansournia MA, Saeedi S, et al. The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. J Endocrinol Invest. 2014;37(5):473-6.
Mansournia, N., Mansournia, M. A., Saeedi, S., & Dehghan, J. (2014). The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. Journal of Endocrinological Investigation, 37(5), 473-6. https://doi.org/10.1007/s40618-014-0064-y
Mansournia N, et al. The Association Between Serum 25OHD Levels and Hypothyroid Hashimoto's Thyroiditis. J Endocrinol Invest. 2014;37(5):473-6. PubMed PMID: 24639121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. AU - Mansournia,Nasrin, AU - Mansournia,Mohammad Ali, AU - Saeedi,Sandra, AU - Dehghan,Jafar, Y1 - 2014/03/18/ PY - 2013/12/28/received PY - 2014/02/11/accepted PY - 2014/3/19/entrez PY - 2014/3/19/pubmed PY - 2015/6/24/medline SP - 473 EP - 6 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 37 IS - 5 N2 - BACKGROUND: Vitamin D is shown to be a potent immunomodulator. Considering the potential role of low serum vitamin D levels in autoimmune disorder, we evaluated the association between Hashimoto's thyroiditis (HT) (with subclinical or overt hypothyroidism) and serum 25-hydroxyvitamin D (25OHD) levels in an Iranian population. METHODS: A total number of 86 individuals were enrolled. The case group included 41 patients with hypothyroid HT (overt or subclinical). The control group comprised 45 healthy euthyroid persons. Serum 25OHD levels were measured in all subjects. THE CASE: control ratio of geometric means of 25OHD levels was 0.66 (95 % CI: 0.49-0.90; P = 0.008). There was a significant inverse association between serum 25OHD levels and HT (OR: 0.81 for 5 ng/ml increase in 25OHD level, 95 % CI: 0.68-0.96; P = 0.018). This association remained significant after adjustment for potential confounding factors including age, sex and BMI. CONCLUSIONS: Our study suggested that higher serum 25OHD levels was associated with decreased risk of HT so that each 5 ng/ml increase in the serum 25OHD levels results in 19 % decrease in odds of HT. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/24639121/The_association_between_serum_25OHD_levels_and_hypothyroid_Hashimoto's_thyroiditis_ L2 - https://link.springer.com/article/10.1007/s40618-014-0064-y DB - PRIME DP - Unbound Medicine ER -