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Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism.
Curr Pharm Des. 2014; 20(38):6048-57.CP

Abstract

Immune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a characteristic feature of ageing. Immune deviations which are most widely expressed in the elderly include increased neopterin production and tryptophan breakdown. These biochemical events result from the activation of the immune system and are preferentially triggered by pro-inflammatory stimuli, such as the Th1-type cytokine interferon-γ. They seem to play a role in the development of several age-related disorders and might be involved in the pathogenesis of common symptoms, including neurobehavioral disorders (e.g., cognitive and mood disturbances), anemia, cachexia, weight-loss but also immunodeficiency. Concentrations of the biomarkers neopterin and Kyn/Trp were found to be predictive of overall disease specific mortality in coronary artery disease, infections and various types of cancer. Immune activation and inflammation are also accompanied by high output of reactive oxygen species and thereby may lead to the development of oxidative stress and contribute to the vitamin deficiency which is often observed in the elderly. Accordingly, increases in neopterin were found to correlate with a substantial decline in key vitamins, including folate and vitamin-B6, - B12, -C, -D and -E.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDivision of Biological Chemistry, Biocenter, Innsbruck Medical University, Center for Chemistry and Biochemistry, Innsbruck, Austria. dietmar.fuchs@i-med.ac.at.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24641220

Citation

Capuron, Lucile, et al. "Activated Immune System and Inflammation in Healthy Ageing: Relevance for Tryptophan and Neopterin Metabolism." Current Pharmaceutical Design, vol. 20, no. 38, 2014, pp. 6048-57.
Capuron L, Geisler S, Kurz K, et al. Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism. Curr Pharm Des. 2014;20(38):6048-57.
Capuron, L., Geisler, S., Kurz, K., Leblhuber, F., Sperner-Unterweger, B., & Fuchs, D. (2014). Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism. Current Pharmaceutical Design, 20(38), 6048-57.
Capuron L, et al. Activated Immune System and Inflammation in Healthy Ageing: Relevance for Tryptophan and Neopterin Metabolism. Curr Pharm Des. 2014;20(38):6048-57. PubMed PMID: 24641220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism. AU - Capuron,Lucile, AU - Geisler,Simon, AU - Kurz,Katharina, AU - Leblhuber,Friedrich, AU - Sperner-Unterweger,Barbara, AU - Fuchs,Dietmar, PY - 2013/10/02/received PY - 2014/03/12/accepted PY - 2014/3/20/entrez PY - 2014/3/20/pubmed PY - 2015/6/24/medline SP - 6048 EP - 57 JF - Current pharmaceutical design JO - Curr. Pharm. Des. VL - 20 IS - 38 N2 - Immune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a characteristic feature of ageing. Immune deviations which are most widely expressed in the elderly include increased neopterin production and tryptophan breakdown. These biochemical events result from the activation of the immune system and are preferentially triggered by pro-inflammatory stimuli, such as the Th1-type cytokine interferon-γ. They seem to play a role in the development of several age-related disorders and might be involved in the pathogenesis of common symptoms, including neurobehavioral disorders (e.g., cognitive and mood disturbances), anemia, cachexia, weight-loss but also immunodeficiency. Concentrations of the biomarkers neopterin and Kyn/Trp were found to be predictive of overall disease specific mortality in coronary artery disease, infections and various types of cancer. Immune activation and inflammation are also accompanied by high output of reactive oxygen species and thereby may lead to the development of oxidative stress and contribute to the vitamin deficiency which is often observed in the elderly. Accordingly, increases in neopterin were found to correlate with a substantial decline in key vitamins, including folate and vitamin-B6, - B12, -C, -D and -E. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/24641220/Activated_immune_system_and_inflammation_in_healthy_ageing:_relevance_for_tryptophan_and_neopterin_metabolism_ L2 - http://www.eurekaselect.com/120991/article DB - PRIME DP - Unbound Medicine ER -