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Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas.Br J Cancer. 2014 Apr 29; 110(9):2246-9.BJ
Abstract
BACKGROUND
Kinase module of Mediator complex ('CDK8 submodule') consists of four subunits: CDK8, Cyclin C, MED12, and MED13. Recently, we reported recurrent MED12 mutations in 70% of uterine leiomyomas. The aim of this study was to analyse whether mutations in other components of the module contribute to the development of these lesions.
METHODS
Mutation screening of altogether 70 MED12 mutation-negative uterine leiomyomas was carried out by direct sequencing.
RESULTS
None of the tumours displayed somatic mutations in the coding regions of CDK8/CDK19, CCNC, or MED13.
CONCLUSIONS
Mutations in CDK8/CDK19, CCNC, and MED13 do not frequently contribute to genesis of uterine leiomyomas.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
24642626
Citation
Mäkinen, N, et al. "Mutation Analysis of Components of the Mediator Kinase Module in MED12 Mutation-negative Uterine Leiomyomas." British Journal of Cancer, vol. 110, no. 9, 2014, pp. 2246-9.
Mäkinen N, Heinonen HR, Sjöberg J, et al. Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas. Br J Cancer. 2014;110(9):2246-9.
Mäkinen, N., Heinonen, H. R., Sjöberg, J., Taipale, J., Vahteristo, P., & Aaltonen, L. A. (2014). Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas. British Journal of Cancer, 110(9), 2246-9. https://doi.org/10.1038/bjc.2014.138
Mäkinen N, et al. Mutation Analysis of Components of the Mediator Kinase Module in MED12 Mutation-negative Uterine Leiomyomas. Br J Cancer. 2014 Apr 29;110(9):2246-9. PubMed PMID: 24642626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas.
AU - Mäkinen,N,
AU - Heinonen,H-R,
AU - Sjöberg,J,
AU - Taipale,J,
AU - Vahteristo,P,
AU - Aaltonen,L A,
Y1 - 2014/03/18/
PY - 2013/11/22/received
PY - 2014/02/14/revised
PY - 2014/02/21/accepted
PY - 2014/3/20/entrez
PY - 2014/3/20/pubmed
PY - 2014/7/7/medline
SP - 2246
EP - 9
JF - British journal of cancer
JO - Br J Cancer
VL - 110
IS - 9
N2 - BACKGROUND: Kinase module of Mediator complex ('CDK8 submodule') consists of four subunits: CDK8, Cyclin C, MED12, and MED13. Recently, we reported recurrent MED12 mutations in 70% of uterine leiomyomas. The aim of this study was to analyse whether mutations in other components of the module contribute to the development of these lesions. METHODS: Mutation screening of altogether 70 MED12 mutation-negative uterine leiomyomas was carried out by direct sequencing. RESULTS: None of the tumours displayed somatic mutations in the coding regions of CDK8/CDK19, CCNC, or MED13. CONCLUSIONS: Mutations in CDK8/CDK19, CCNC, and MED13 do not frequently contribute to genesis of uterine leiomyomas.
SN - 1532-1827
UR - https://www.unboundmedicine.com/medline/citation/24642626/Mutation_analysis_of_components_of_the_Mediator_kinase_module_in_MED12_mutation_negative_uterine_leiomyomas_
L2 - https://doi.org/10.1038/bjc.2014.138
DB - PRIME
DP - Unbound Medicine
ER -