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The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control study.
Arch Gynecol Obstet. 2014 Aug; 290(2):315-9.AG

Abstract

BACKGROUND

Previous studies have shown increased inflammatory activity in patients with polycystic ovary syndrome (PCOS); however, it remains uncertain whether this increased inflammatory activity is a consequence of the disorder itself or of the accompanying obesity. We therefore aimed to test the inflammatory marker levels in obese and lean patients with PCOS by using two separate control groups with matching body mass index (BMI).

METHOD

A total of 120 women in reproductive age with (n = 62) and without (n = 60) PCOS were recruited for the study. Patients with PCOS were divided into two groups as obese (n = 32) and lean (n = 30) PCOS groups according to BMI. Two BMI-matched control groups were created. Furthermore, high sensitive CRP protein (hsCRP), neutrophils, lymphocytes, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) were evaluated with complete blood count.

RESULTS

The hsCRP (5.5 ± 0.8 vs. 3.1 ± 0.7, p < 0.001), neutrophil count (3.8 ± 0.4 vs. 2.9 ± 0.7, p < 0.001), leukocyte count (7.2 ± 1.8 vs. 5.6 ± 1.6, p < 0.001), and NLR (2.6 ± 1.4 vs. 1.5 ± 0.4, p < 0.001) were higher in patients with PCOS compared to the control group while lymphocyte count was lower (1.71 ± 0.65 vs. 1.98 ± 0.39, p = 0.008). Similarly, both obese and lean patients with PCOS had higher levels of hsCRP, neutrophils, leukocytes and NLR ratios compared to BMI-matched controls. The correlation analysis revealed a moderate correlation between NLR and hsCRP (r 0.459, p < 0.001), and between HOMA-IR (r 0.476 p < 0.001) and BMI (r 0.310, p 0.001).

CONCLUSION

Our study results demonstrated that both lean and obese patients with PCOS have increased inflammatory markers compared to BMI-matched control groups indicating that the inflammation seen in PCOS might be related with the presence of the disorder rather than with obesity.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Keskin Kurt R
Department of Obstetrics and Gynecology, Mustafa Kemal University Medical School, Hatay, 31100, Turkey, drraziyekeskinkurt@yahoo.com.
Okyay AG
No affiliation info available
Hakverdi AU
No affiliation info available
Gungoren A
No affiliation info available
Dolapcioglu KS
No affiliation info available
Karateke A
No affiliation info available
Dogan MO
No affiliation info available

MeSH

AdultBiomarkersBlood Cell CountBody Mass IndexC-Reactive ProteinCase-Control StudiesFemaleHumansInflammationObesityPolycystic Ovary SyndromeThinness

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24643802

Citation

Keskin Kurt, Raziye, et al. "The Effect of Obesity On Inflammatory Markers in Patients With PCOS: a BMI-matched Case-control Study." Archives of Gynecology and Obstetrics, vol. 290, no. 2, 2014, pp. 315-9.
Keskin Kurt R, Okyay AG, Hakverdi AU, et al. The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control study. Arch Gynecol Obstet. 2014;290(2):315-9.
Keskin Kurt, R., Okyay, A. G., Hakverdi, A. U., Gungoren, A., Dolapcioglu, K. S., Karateke, A., & Dogan, M. O. (2014). The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control study. Archives of Gynecology and Obstetrics, 290(2), 315-9. https://doi.org/10.1007/s00404-014-3199-3
Keskin Kurt R, et al. The Effect of Obesity On Inflammatory Markers in Patients With PCOS: a BMI-matched Case-control Study. Arch Gynecol Obstet. 2014;290(2):315-9. PubMed PMID: 24643802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control study. AU - Keskin Kurt,Raziye, AU - Okyay,Ayşe Güler, AU - Hakverdi,Ali Ulvi, AU - Gungoren,Arif, AU - Dolapcioglu,Kenan Serdar, AU - Karateke,Atilla, AU - Dogan,Mustafa Ozcil, Y1 - 2014/03/19/ PY - 2013/08/23/received PY - 2014/02/28/accepted PY - 2014/3/20/entrez PY - 2014/3/20/pubmed PY - 2014/10/4/medline SP - 315 EP - 9 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 290 IS - 2 N2 - BACKGROUND: Previous studies have shown increased inflammatory activity in patients with polycystic ovary syndrome (PCOS); however, it remains uncertain whether this increased inflammatory activity is a consequence of the disorder itself or of the accompanying obesity. We therefore aimed to test the inflammatory marker levels in obese and lean patients with PCOS by using two separate control groups with matching body mass index (BMI). METHOD: A total of 120 women in reproductive age with (n = 62) and without (n = 60) PCOS were recruited for the study. Patients with PCOS were divided into two groups as obese (n = 32) and lean (n = 30) PCOS groups according to BMI. Two BMI-matched control groups were created. Furthermore, high sensitive CRP protein (hsCRP), neutrophils, lymphocytes, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) were evaluated with complete blood count. RESULTS: The hsCRP (5.5 ± 0.8 vs. 3.1 ± 0.7, p < 0.001), neutrophil count (3.8 ± 0.4 vs. 2.9 ± 0.7, p < 0.001), leukocyte count (7.2 ± 1.8 vs. 5.6 ± 1.6, p < 0.001), and NLR (2.6 ± 1.4 vs. 1.5 ± 0.4, p < 0.001) were higher in patients with PCOS compared to the control group while lymphocyte count was lower (1.71 ± 0.65 vs. 1.98 ± 0.39, p = 0.008). Similarly, both obese and lean patients with PCOS had higher levels of hsCRP, neutrophils, leukocytes and NLR ratios compared to BMI-matched controls. The correlation analysis revealed a moderate correlation between NLR and hsCRP (r 0.459, p < 0.001), and between HOMA-IR (r 0.476 p < 0.001) and BMI (r 0.310, p 0.001). CONCLUSION: Our study results demonstrated that both lean and obese patients with PCOS have increased inflammatory markers compared to BMI-matched control groups indicating that the inflammation seen in PCOS might be related with the presence of the disorder rather than with obesity. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/24643802/The_effect_of_obesity_on_inflammatory_markers_in_patients_with_PCOS:_a_BMI_matched_case_control_study_ DB - PRIME DP - Unbound Medicine ER -