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Early risk factors for psychopathology in offspring of parents with bipolar disorder: the role of obstetric complications and maternal comorbid anxiety.
Depress Anxiety. 2014 Jul; 31(7):583-90.DA

Abstract

OBJECTIVE

Offspring of parents with bipolar disorder (BD) are at increased risk for developing a range of psychiatric disorders. Although genetic factors clearly confer risk to offspring, environmental factors also play a role in increasing vulnerability. Such environmental factors may occur at the initial stages of development in the form of obstetric complications (OCs). The current investigation examined the relationship between OCs and the development of psychopathology in offspring at risk for BD and the influence of parental psychopathology in this relationship.

METHODS

This cross-sectional study included 206 offspring of 119 parents with BD. Probit regression analyses examined associations between: (1) OC history and offspring psychopathology; and (2) maternal lifetime comorbid anxiety diagnoses and OCs in pregnancy/delivery with their offspring. Path analyses then tested whether OCs mediate the relationship between maternal comorbid anxiety disorders and offspring lifetime psychopathology.

RESULTS

Results indicated a specific association between OCs, particularly delivery complications, and increased risk for offspring anxiety disorders. Data also showed a significant relationship between maternal anxiety disorder comorbidity and OCs. Finally, path analyses suggested that delivery complications act as a mediator in the relationship between comorbid maternal anxiety disorder and offspring anxiety disorder.

CONCLUSIONS

Our findings lend support to the importance of identifying and reducing anxiety in pregnant woman with BD. The identification of OCs as early vulnerability factors for psychopathology in offspring at familial risk may also lead to earlier detection and intervention in these offspring.

Authors+Show Affiliations

Department of Psychology, Boston University, Boston, Massachusetts.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24643978

Citation

Freed, Rachel D., et al. "Early Risk Factors for Psychopathology in Offspring of Parents With Bipolar Disorder: the Role of Obstetric Complications and Maternal Comorbid Anxiety." Depression and Anxiety, vol. 31, no. 7, 2014, pp. 583-90.
Freed RD, Tompson MC, Otto MW, et al. Early risk factors for psychopathology in offspring of parents with bipolar disorder: the role of obstetric complications and maternal comorbid anxiety. Depress Anxiety. 2014;31(7):583-90.
Freed, R. D., Tompson, M. C., Otto, M. W., Nierenberg, A. A., Hirshfeld-Becker, D., Wang, C. H., & Henin, A. (2014). Early risk factors for psychopathology in offspring of parents with bipolar disorder: the role of obstetric complications and maternal comorbid anxiety. Depression and Anxiety, 31(7), 583-90. https://doi.org/10.1002/da.22254
Freed RD, et al. Early Risk Factors for Psychopathology in Offspring of Parents With Bipolar Disorder: the Role of Obstetric Complications and Maternal Comorbid Anxiety. Depress Anxiety. 2014;31(7):583-90. PubMed PMID: 24643978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early risk factors for psychopathology in offspring of parents with bipolar disorder: the role of obstetric complications and maternal comorbid anxiety. AU - Freed,Rachel D, AU - Tompson,Martha C, AU - Otto,Michael W, AU - Nierenberg,Andrew A, AU - Hirshfeld-Becker,Dina, AU - Wang,Christine H, AU - Henin,Aude, Y1 - 2014/03/18/ PY - 2013/10/17/received PY - 2014/01/22/revised PY - 2014/01/24/accepted PY - 2014/3/20/entrez PY - 2014/3/20/pubmed PY - 2015/3/31/medline KW - anxiety disorder KW - bipolar disorder KW - obstetric complications KW - offspring of impaired parents KW - risk factors SP - 583 EP - 90 JF - Depression and anxiety JO - Depress Anxiety VL - 31 IS - 7 N2 - OBJECTIVE: Offspring of parents with bipolar disorder (BD) are at increased risk for developing a range of psychiatric disorders. Although genetic factors clearly confer risk to offspring, environmental factors also play a role in increasing vulnerability. Such environmental factors may occur at the initial stages of development in the form of obstetric complications (OCs). The current investigation examined the relationship between OCs and the development of psychopathology in offspring at risk for BD and the influence of parental psychopathology in this relationship. METHODS: This cross-sectional study included 206 offspring of 119 parents with BD. Probit regression analyses examined associations between: (1) OC history and offspring psychopathology; and (2) maternal lifetime comorbid anxiety diagnoses and OCs in pregnancy/delivery with their offspring. Path analyses then tested whether OCs mediate the relationship between maternal comorbid anxiety disorders and offspring lifetime psychopathology. RESULTS: Results indicated a specific association between OCs, particularly delivery complications, and increased risk for offspring anxiety disorders. Data also showed a significant relationship between maternal anxiety disorder comorbidity and OCs. Finally, path analyses suggested that delivery complications act as a mediator in the relationship between comorbid maternal anxiety disorder and offspring anxiety disorder. CONCLUSIONS: Our findings lend support to the importance of identifying and reducing anxiety in pregnant woman with BD. The identification of OCs as early vulnerability factors for psychopathology in offspring at familial risk may also lead to earlier detection and intervention in these offspring. SN - 1520-6394 UR - https://www.unboundmedicine.com/medline/citation/24643978/Early_risk_factors_for_psychopathology_in_offspring_of_parents_with_bipolar_disorder:_the_role_of_obstetric_complications_and_maternal_comorbid_anxiety_ L2 - https://doi.org/10.1002/da.22254 DB - PRIME DP - Unbound Medicine ER -