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Serologic responses to Mycobacterium leprae-specific phenolic glycolipid-I antigen in sooty mangabey monkeys with experimental leprosy.
Int J Lepr Other Mycobact Dis. 1988 Dec; 56(4):537-45.IJ

Abstract

Four pairs of sooty mangabey monkeys (Cercocebus atys) were inoculated with serial, 10-fold dilutions of Mycobacterium leprae. The highest-dose pair received 4.8 X 10(10) M. leprae. Serum samples were obtained and clinical signs of leprosy were recorded at intervals of 35 months. Longitudinal serum samples were assayed by an ELISA method for the presence of IgG and IgM antibodies to the M. Leprae-specific phenolic glycolipid-I (PGL-I) antigen. In general, the onset of disease symptoms paralleled the number of M. leprae inoculated, but the ultimate course of disease depended upon individual animal susceptibility. Both IgG and IgM anti-PGL-I isotypes were observed in variable levels and patterns, related to the disease stage, among the eight mangabeys. The data suggest that high IgG and low IgM anti-PGL-I levels correlated with less severe disease; whereas initial high IgM titers and/or rising or sustained high IgM titers, especially together with low IgG anti-PGL-I titers, preceded or corresponded to periods of progressive leprosy. The results show that IgG and IgM anti-PGL-I antibodies can be present in significant titers among mangabeys early after infection with M. leprae. It appears likely that the relative levels of these anti-PGL-I isotypes may be correlated with the susceptibility of individual animals to the development of lepromatous leprosy.

Authors+Show Affiliations

Gormus BJ
Department of Microbiology, Delta Regional Primate Research Center, Tulane University, Covington, Louisiana 70433.
Ohashi DK
No affiliation info available
Ohkawa S
No affiliation info available
Walsh GP
No affiliation info available
Meyers WM
No affiliation info available
Brennan PJ
No affiliation info available
Trygg C
No affiliation info available

MeSH

AnimalsAntibodies, BacterialAntigens, BacterialCercopithecidaeEnzyme-Linked Immunosorbent AssayEpitopesGlycolipidsImmunoglobulin GImmunoglobulin MLeprosyMaleMycobacterium leprae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2464657

Citation

Gormus, B J., et al. "Serologic Responses to Mycobacterium Leprae-specific Phenolic glycolipid-I Antigen in Sooty Mangabey Monkeys With Experimental Leprosy." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 56, no. 4, 1988, pp. 537-45.
Gormus BJ, Ohashi DK, Ohkawa S, et al. Serologic responses to Mycobacterium leprae-specific phenolic glycolipid-I antigen in sooty mangabey monkeys with experimental leprosy. Int J Lepr Other Mycobact Dis. 1988;56(4):537-45.
Gormus, B. J., Ohashi, D. K., Ohkawa, S., Walsh, G. P., Meyers, W. M., Brennan, P. J., & Trygg, C. (1988). Serologic responses to Mycobacterium leprae-specific phenolic glycolipid-I antigen in sooty mangabey monkeys with experimental leprosy. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 56(4), 537-45.
Gormus BJ, et al. Serologic Responses to Mycobacterium Leprae-specific Phenolic glycolipid-I Antigen in Sooty Mangabey Monkeys With Experimental Leprosy. Int J Lepr Other Mycobact Dis. 1988;56(4):537-45. PubMed PMID: 2464657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serologic responses to Mycobacterium leprae-specific phenolic glycolipid-I antigen in sooty mangabey monkeys with experimental leprosy. AU - Gormus,B J, AU - Ohashi,D K, AU - Ohkawa,S, AU - Walsh,G P, AU - Meyers,W M, AU - Brennan,P J, AU - Trygg,C, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 537 EP - 45 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 56 IS - 4 N2 - Four pairs of sooty mangabey monkeys (Cercocebus atys) were inoculated with serial, 10-fold dilutions of Mycobacterium leprae. The highest-dose pair received 4.8 X 10(10) M. leprae. Serum samples were obtained and clinical signs of leprosy were recorded at intervals of 35 months. Longitudinal serum samples were assayed by an ELISA method for the presence of IgG and IgM antibodies to the M. Leprae-specific phenolic glycolipid-I (PGL-I) antigen. In general, the onset of disease symptoms paralleled the number of M. leprae inoculated, but the ultimate course of disease depended upon individual animal susceptibility. Both IgG and IgM anti-PGL-I isotypes were observed in variable levels and patterns, related to the disease stage, among the eight mangabeys. The data suggest that high IgG and low IgM anti-PGL-I levels correlated with less severe disease; whereas initial high IgM titers and/or rising or sustained high IgM titers, especially together with low IgG anti-PGL-I titers, preceded or corresponded to periods of progressive leprosy. The results show that IgG and IgM anti-PGL-I antibodies can be present in significant titers among mangabeys early after infection with M. leprae. It appears likely that the relative levels of these anti-PGL-I isotypes may be correlated with the susceptibility of individual animals to the development of lepromatous leprosy. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2464657/Serologic_responses_to_Mycobacterium_leprae_specific_phenolic_glycolipid_I_antigen_in_sooty_mangabey_monkeys_with_experimental_leprosy_ DB - PRIME DP - Unbound Medicine ER -