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Dietary intake of vitamin K is inversely associated with mortality risk.
J Nutr. 2014 May; 144(5):743-50.JN

Abstract

Vitamin K has been related to cardiovascular disease and cancer risk. However, data on total mortality are scarce. The aim of the present study was to assess the association between the dietary intake of different types of vitamin K and mortality in a Mediterranean population at high cardiovascular disease risk. A prospective cohort analysis was conducted in 7216 participants from the PREDIMED (Prevención con Dieta Mediterránea) study (median follow-up of 4.8 y). Energy and nutrient intakes were evaluated using a validated 137-item food frequency questionnaire. Dietary vitamin K intake was calculated annually using the USDA food composition database and other published sources. Deaths were ascertained by an end-point adjudication committee unaware of the dietary habits of participants after they had reviewed medical records and linked up to the National Death Index. Cox proportional hazard models were fitted to assess the RR of mortality. Energy-adjusted baseline dietary phylloquinone intake was inversely associated with a significantly reduced risk of cancer and all-cause mortality after controlling for potential confounders (HR: 0.54; 95% CI: 0.30, 0.96; and HR: 0.64; 95% CI: 0.45, 0.90, respectively). In longitudinal assessments, individuals who increased their intake of phylloquinone or menaquinone during follow-up had a lower risk of cancer (HR: 0.64; 95% CI: 0.43, 0.95; and HR: 0.41; 95% CI: 0.26, 0.64, respectively) and all-cause mortality (HR: 0.57; 95% CI: 0.44, 0.73; and HR: 0.55; 95% CI: 0.42, 0.73, respectively) than individuals who decreased or did not change their intake. Also, individuals who increased their intake of dietary phylloquinone had a lower risk of cardiovascular mortality risk (HR: 0.52; 95% CI: 0.31, 0.86). However, no association between changes in menaquinone intake and cardiovascular mortality was observed (HR: 0.76; 95% CI: 0.44, 1.29). An increase in dietary intake of vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality in a Mediterranean population at high cardiovascular disease risk. This trial was registered at http://www.controlled-trials.com as ISRCTN35739639.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Juanola-Falgarona M
Human Nutrition Unit, Department of Biochemistry and Biotechnology, Sant Joan de Reus University Hospital, Faculty of Medicine and Health Sciences, Pere Virgili Institute of Health Research.
Salas-Salvadó J
No affiliation info available
Martínez-González MÁ
No affiliation info available
Corella D
No affiliation info available
Estruch R
No affiliation info available
Ros E
No affiliation info available
Fitó M
No affiliation info available
Arós F
No affiliation info available
Gómez-Gracia E
No affiliation info available
Fiol M
No affiliation info available
Lapetra J
No affiliation info available
Basora J
No affiliation info available
Lamuela-Raventós RM
No affiliation info available
Serra-Majem L
No affiliation info available
Pintó X
No affiliation info available
Muñoz MÁ
No affiliation info available
Ruiz-Gutiérrez V
No affiliation info available
Fernández-Ballart J
No affiliation info available
Bulló M
No affiliation info available

MeSH

AgedAged, 80 and overCardiovascular DiseasesDiabetes Mellitus, Type 2Diet, MediterraneanFemaleFollow-Up StudiesHumansIncidenceMaleMediterranean RegionMiddle AgedNeoplasmsPlant OilsProportional Hazards ModelsProspective StudiesRisk FactorsVegetablesVitamin KVitamin K 1Vitamin K 2

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24647393

Citation

Juanola-Falgarona, Martí, et al. "Dietary Intake of Vitamin K Is Inversely Associated With Mortality Risk." The Journal of Nutrition, vol. 144, no. 5, 2014, pp. 743-50.
Juanola-Falgarona M, Salas-Salvadó J, Martínez-González MÁ, et al. Dietary intake of vitamin K is inversely associated with mortality risk. J Nutr. 2014;144(5):743-50.
Juanola-Falgarona, M., Salas-Salvadó, J., Martínez-González, M. Á., Corella, D., Estruch, R., Ros, E., Fitó, M., Arós, F., Gómez-Gracia, E., Fiol, M., Lapetra, J., Basora, J., Lamuela-Raventós, R. M., Serra-Majem, L., Pintó, X., Muñoz, M. Á., Ruiz-Gutiérrez, V., Fernández-Ballart, J., & Bulló, M. (2014). Dietary intake of vitamin K is inversely associated with mortality risk. The Journal of Nutrition, 144(5), 743-50. https://doi.org/10.3945/jn.113.187740
Juanola-Falgarona M, et al. Dietary Intake of Vitamin K Is Inversely Associated With Mortality Risk. J Nutr. 2014;144(5):743-50. PubMed PMID: 24647393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of vitamin K is inversely associated with mortality risk. AU - Juanola-Falgarona,Martí, AU - Salas-Salvadó,Jordi, AU - Martínez-González,Miguel Ángel, AU - Corella,Dolores, AU - Estruch,Ramón, AU - Ros,Emili, AU - Fitó,Montserrat, AU - Arós,Fernando, AU - Gómez-Gracia,Enrique, AU - Fiol,Miquel, AU - Lapetra,José, AU - Basora,Josep, AU - Lamuela-Raventós,Rosa María, AU - Serra-Majem,Lluis, AU - Pintó,Xavier, AU - Muñoz,Miguel Ángel, AU - Ruiz-Gutiérrez,Valentina, AU - Fernández-Ballart,Joan, AU - Bulló,Mònica, Y1 - 2014/03/19/ PY - 2014/3/21/entrez PY - 2014/3/22/pubmed PY - 2014/6/11/medline SP - 743 EP - 50 JF - The Journal of nutrition JO - J Nutr VL - 144 IS - 5 N2 - Vitamin K has been related to cardiovascular disease and cancer risk. However, data on total mortality are scarce. The aim of the present study was to assess the association between the dietary intake of different types of vitamin K and mortality in a Mediterranean population at high cardiovascular disease risk. A prospective cohort analysis was conducted in 7216 participants from the PREDIMED (Prevención con Dieta Mediterránea) study (median follow-up of 4.8 y). Energy and nutrient intakes were evaluated using a validated 137-item food frequency questionnaire. Dietary vitamin K intake was calculated annually using the USDA food composition database and other published sources. Deaths were ascertained by an end-point adjudication committee unaware of the dietary habits of participants after they had reviewed medical records and linked up to the National Death Index. Cox proportional hazard models were fitted to assess the RR of mortality. Energy-adjusted baseline dietary phylloquinone intake was inversely associated with a significantly reduced risk of cancer and all-cause mortality after controlling for potential confounders (HR: 0.54; 95% CI: 0.30, 0.96; and HR: 0.64; 95% CI: 0.45, 0.90, respectively). In longitudinal assessments, individuals who increased their intake of phylloquinone or menaquinone during follow-up had a lower risk of cancer (HR: 0.64; 95% CI: 0.43, 0.95; and HR: 0.41; 95% CI: 0.26, 0.64, respectively) and all-cause mortality (HR: 0.57; 95% CI: 0.44, 0.73; and HR: 0.55; 95% CI: 0.42, 0.73, respectively) than individuals who decreased or did not change their intake. Also, individuals who increased their intake of dietary phylloquinone had a lower risk of cardiovascular mortality risk (HR: 0.52; 95% CI: 0.31, 0.86). However, no association between changes in menaquinone intake and cardiovascular mortality was observed (HR: 0.76; 95% CI: 0.44, 1.29). An increase in dietary intake of vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality in a Mediterranean population at high cardiovascular disease risk. This trial was registered at http://www.controlled-trials.com as ISRCTN35739639. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/24647393/Dietary_intake_of_vitamin_K_is_inversely_associated_with_mortality_risk_ DB - PRIME DP - Unbound Medicine ER -