Pd(II)-catalyzed one-step construction of cycloalkane-fused indoles and its application in formal synthesis of (±)-aspidospermidine.Org Lett. 2014 Apr 04; 16(7):2058-61.OL
Abstract
A highly efficient, redox-free Pd(II)-catalyzed tandem cyclization reaction initiated by intramolecular aminopalladation of alkynes followed by nucleophilic addition to nitriles is developed. This method provides a versatile approach for the synthesis of six- to eight-membered ring-fused indoles in one step and has also shown advantages in the formal synthesis of (±)-aspidospermidine.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
24650163
Citation
Xia, Guoqin, et al. "Pd(II)-catalyzed One-step Construction of Cycloalkane-fused Indoles and Its Application in Formal Synthesis of (±)-aspidospermidine." Organic Letters, vol. 16, no. 7, 2014, pp. 2058-61.
Xia G, Han X, Lu X. Pd(II)-catalyzed one-step construction of cycloalkane-fused indoles and its application in formal synthesis of (±)-aspidospermidine. Org Lett. 2014;16(7):2058-61.
Xia, G., Han, X., & Lu, X. (2014). Pd(II)-catalyzed one-step construction of cycloalkane-fused indoles and its application in formal synthesis of (±)-aspidospermidine. Organic Letters, 16(7), 2058-61. https://doi.org/10.1021/ol500662f
Xia G, Han X, Lu X. Pd(II)-catalyzed One-step Construction of Cycloalkane-fused Indoles and Its Application in Formal Synthesis of (±)-aspidospermidine. Org Lett. 2014 Apr 4;16(7):2058-61. PubMed PMID: 24650163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Pd(II)-catalyzed one-step construction of cycloalkane-fused indoles and its application in formal synthesis of (±)-aspidospermidine.
AU - Xia,Guoqin,
AU - Han,Xiuling,
AU - Lu,Xiyan,
Y1 - 2014/03/21/
PY - 2014/3/22/entrez
PY - 2014/3/22/pubmed
PY - 2014/6/21/medline
SP - 2058
EP - 61
JF - Organic letters
JO - Org Lett
VL - 16
IS - 7
N2 - A highly efficient, redox-free Pd(II)-catalyzed tandem cyclization reaction initiated by intramolecular aminopalladation of alkynes followed by nucleophilic addition to nitriles is developed. This method provides a versatile approach for the synthesis of six- to eight-membered ring-fused indoles in one step and has also shown advantages in the formal synthesis of (±)-aspidospermidine.
SN - 1523-7052
UR - https://www.unboundmedicine.com/medline/citation/24650163/Pd_II__catalyzed_one_step_construction_of_cycloalkane_fused_indoles_and_its_application_in_formal_synthesis_of__±__aspidospermidine_
DB - PRIME
DP - Unbound Medicine
ER -
