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Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats.
J Med Food. 2014 Mar; 17(3):339-49.JM

Abstract

The effect of pomegranate juice (PJ) on hepatic antioxidant enzyme activities, lipid peroxidation, DNA fragmentation (DNAF), and caspase-3 activity in rats both treated and not treated with diethylnitrosamine (DEN) and phenobarbital (PB) was studied. Administration of rats with DEN and PB caused an elevation in the levels of malondialde-hyde (MDA), DNAF, and activities of glutathione reductase (GSR) and caspase-3, while the activities of superoxide dismutase, glutathione S-transferase, total glutathione peroxidase (t-GPx), and glutathione (GSH) level were decreased in hepatocytes compared to the control. Treatment of rats with PJ pre, during, and post DEN and PB administration improved liver function and decreased the levels of MDA, DNAF, t-GPx, GSR, and caspase-3 activities, but the GSH level did not change compared to the D-P group. This indicates that PJ reduced the oxidative stress and apoptosis induced by DEN and PB. Administration of healthy rats with PJ only for a long period induced oxidative stress and apoptosis for hepatocytes.

Authors+Show Affiliations

1 Biochemistry Department, Faculty of Science, Alexandria University , Alexandria, Egypt .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24650251

Citation

Shaban, Nadia Z., et al. "Effect of Punica Granatum (pomegranate) Juice Extract On Healthy Liver and Hepatotoxicity Induced By Diethylnitrosamine and Phenobarbital in Male Rats." Journal of Medicinal Food, vol. 17, no. 3, 2014, pp. 339-49.
Shaban NZ, El-Kersh MA, Bader-Eldin MM, et al. Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats. J Med Food. 2014;17(3):339-49.
Shaban, N. Z., El-Kersh, M. A., Bader-Eldin, M. M., Kato, S. A., & Hamoda, A. F. (2014). Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats. Journal of Medicinal Food, 17(3), 339-49. https://doi.org/10.1089/jmf.2012.0306
Shaban NZ, et al. Effect of Punica Granatum (pomegranate) Juice Extract On Healthy Liver and Hepatotoxicity Induced By Diethylnitrosamine and Phenobarbital in Male Rats. J Med Food. 2014;17(3):339-49. PubMed PMID: 24650251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats. AU - Shaban,Nadia Z, AU - El-Kersh,Mohamed A R, AU - Bader-Eldin,Mohamed M, AU - Kato,Sosan Amin, AU - Hamoda,Asmaa F, PY - 2014/3/22/entrez PY - 2014/3/22/pubmed PY - 2014/11/18/medline SP - 339 EP - 49 JF - Journal of medicinal food JO - J Med Food VL - 17 IS - 3 N2 - The effect of pomegranate juice (PJ) on hepatic antioxidant enzyme activities, lipid peroxidation, DNA fragmentation (DNAF), and caspase-3 activity in rats both treated and not treated with diethylnitrosamine (DEN) and phenobarbital (PB) was studied. Administration of rats with DEN and PB caused an elevation in the levels of malondialde-hyde (MDA), DNAF, and activities of glutathione reductase (GSR) and caspase-3, while the activities of superoxide dismutase, glutathione S-transferase, total glutathione peroxidase (t-GPx), and glutathione (GSH) level were decreased in hepatocytes compared to the control. Treatment of rats with PJ pre, during, and post DEN and PB administration improved liver function and decreased the levels of MDA, DNAF, t-GPx, GSR, and caspase-3 activities, but the GSH level did not change compared to the D-P group. This indicates that PJ reduced the oxidative stress and apoptosis induced by DEN and PB. Administration of healthy rats with PJ only for a long period induced oxidative stress and apoptosis for hepatocytes. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/24650251/Effect_of_Punica_granatum__pomegranate__juice_extract_on_healthy_liver_and_hepatotoxicity_induced_by_diethylnitrosamine_and_phenobarbital_in_male_rats_ L2 - https://www.liebertpub.com/doi/full/10.1089/jmf.2012.0306?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -