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Follicular mucinosis: clinical and histopathologic study.
J Am Acad Dermatol. 1989 Mar; 20(3):441-6.JA

Abstract

Fifty-nine patients with the histologic diagnosis of follicular mucinosis (alopecia mucinosa) were evaluated retrospectively. Thirty-seven were male and 22 were female; ages ranged from 10 to 76 years. Of 19 patients with mycosis fungoides, 16 had initial lesions of follicular mucinosis on the trunk or extremities. Two patients had Hodgkin's disease and follicular mucinosis; both were younger than 20 years of age. Seven other patients were 20 years of age or younger. Two of the nine adolescent patients had persistent plaques of follicular mucinosis up to 18 years after diagnosis. Evaluation of biopsy specimens for lymphocytes, eosinophils, nonlymphoid cell infiltration, epidermal lymphocytic exocytosis, mucin deposition, and epidermal hyperplasia revealed no predominant feature that differentiated the group with benign disease from the group with mycosis fungoides. We conclude that no single clinical or histopathologic observation predicts which patients with follicular mucinosis will have a benign course and that evaluation of multiple clinical and histologic variables is necessary.

Authors+Show Affiliations

Department of Dermatology, Mayo Clinic, Rochester, MN 55905.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2465327

Citation

Gibson, L E., et al. "Follicular Mucinosis: Clinical and Histopathologic Study." Journal of the American Academy of Dermatology, vol. 20, no. 3, 1989, pp. 441-6.
Gibson LE, Muller SA, Leiferman KM, et al. Follicular mucinosis: clinical and histopathologic study. J Am Acad Dermatol. 1989;20(3):441-6.
Gibson, L. E., Muller, S. A., Leiferman, K. M., & Peters, M. S. (1989). Follicular mucinosis: clinical and histopathologic study. Journal of the American Academy of Dermatology, 20(3), 441-6.
Gibson LE, et al. Follicular Mucinosis: Clinical and Histopathologic Study. J Am Acad Dermatol. 1989;20(3):441-6. PubMed PMID: 2465327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular mucinosis: clinical and histopathologic study. AU - Gibson,L E, AU - Muller,S A, AU - Leiferman,K M, AU - Peters,M S, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 441 EP - 6 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 20 IS - 3 N2 - Fifty-nine patients with the histologic diagnosis of follicular mucinosis (alopecia mucinosa) were evaluated retrospectively. Thirty-seven were male and 22 were female; ages ranged from 10 to 76 years. Of 19 patients with mycosis fungoides, 16 had initial lesions of follicular mucinosis on the trunk or extremities. Two patients had Hodgkin's disease and follicular mucinosis; both were younger than 20 years of age. Seven other patients were 20 years of age or younger. Two of the nine adolescent patients had persistent plaques of follicular mucinosis up to 18 years after diagnosis. Evaluation of biopsy specimens for lymphocytes, eosinophils, nonlymphoid cell infiltration, epidermal lymphocytic exocytosis, mucin deposition, and epidermal hyperplasia revealed no predominant feature that differentiated the group with benign disease from the group with mycosis fungoides. We conclude that no single clinical or histopathologic observation predicts which patients with follicular mucinosis will have a benign course and that evaluation of multiple clinical and histologic variables is necessary. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/2465327/Follicular_mucinosis:_clinical_and_histopathologic_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(89)70055-4 DB - PRIME DP - Unbound Medicine ER -