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Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study.
Nutr Res. 2014 Mar; 34(3):210-8.NR

Abstract

Several dietary recommendations have been made for marine n-3 polyunsaturated fatty acid (PUFA) intake; however, the effectiveness of these fatty acids has not been thoroughly examined. The aim of this study was to investigate whether public-aimed dietary recommendations for long-chain n-3 PUFA from oily fish or fish oil supplements are efficient in optimizing their status in red blood cells (RBCs) and platelets of healthy middle-aged subjects with low customary fish consumption. In a randomized, cross-over trial conducted over an 8-week period and separated by a 6-month washout period, 33 participants received an oily fish (salmon), providing 274 mg eicosapentaenoic acid (EPA) + 671 mg docosahexaenoic acid (DHA) per day, or a commercial fish oil supplement, providing 396 mg EPA + 250 mg DHA per day. Blood samples were collected before and after each intervention period, and RBCs and platelets were used for analysis of fatty acids. After 8 weeks, there were significant increases in EPA and DHA content in RBCs and platelets with both salmon and fish oil capsules. The increase in EPA in both RBCs and platelets was higher with capsules, whereas the increase in DHA in both RBCs and platelets was higher with salmon. In spite of the quantitative and qualitative differences between n-3 fatty acid profiles in salmon and the fish oil supplement, the overall incorporation of these fatty acids into RBCs and platelets did not differ in our short-term study (P > .05). The sum of EPA + DHA significantly increased in both compartments following dietary recommendations for oily fish and fish oil supplements intake in middle-aged healthy subjects with low baseline long-chain n-3 PUFA status, although targeted values with optimal cardioprotective effect of more than 8% were not achieved.

Authors+Show Affiliations

Department of Bromatology, School of Pharmacy, University of Belgrade, Belgrade, Serbia. Electronic address: ivanakaja@yahoo.com.Department of Physiology, School of Medicine, University of Belgrade, Belgrade, Serbia.Department of Medical Biochemistry, School of Pharmacy, University of Belgrade, Belgrade, Serbia.Clinic for Digestive Surgery-I Surgical Clinic, Clinical Center of Serbia, Belgrade, Serbia.Department of Bromatology, School of Pharmacy, University of Belgrade, Belgrade, Serbia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24655487

Citation

Djuricic, Ivana D., et al. "Long-chain N-3 Polyunsaturated Fatty Acid Dietary Recommendations Are Moderately Efficient in Optimizing Their Status in Healthy Middle-aged Subjects With Low Fish Consumption: a Cross-over Study." Nutrition Research (New York, N.Y.), vol. 34, no. 3, 2014, pp. 210-8.
Djuricic ID, Mazic SD, Kotur-Stevuljevic JM, et al. Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study. Nutr Res. 2014;34(3):210-8.
Djuricic, I. D., Mazic, S. D., Kotur-Stevuljevic, J. M., Djordjevic, V. R., & Sobajic, S. S. (2014). Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study. Nutrition Research (New York, N.Y.), 34(3), 210-8. https://doi.org/10.1016/j.nutres.2013.12.008
Djuricic ID, et al. Long-chain N-3 Polyunsaturated Fatty Acid Dietary Recommendations Are Moderately Efficient in Optimizing Their Status in Healthy Middle-aged Subjects With Low Fish Consumption: a Cross-over Study. Nutr Res. 2014;34(3):210-8. PubMed PMID: 24655487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study. AU - Djuricic,Ivana D, AU - Mazic,Sanja D, AU - Kotur-Stevuljevic,Jelena M, AU - Djordjevic,Vladimir R, AU - Sobajic,Sladjana S, Y1 - 2014/01/03/ PY - 2013/09/30/received PY - 2013/12/25/revised PY - 2013/12/30/accepted PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2014/12/15/medline KW - Fed blood cells KW - Fish KW - Fish oil supplements KW - Humans KW - Platelets KW - n-3 fatty acids SP - 210 EP - 8 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 3 N2 - Several dietary recommendations have been made for marine n-3 polyunsaturated fatty acid (PUFA) intake; however, the effectiveness of these fatty acids has not been thoroughly examined. The aim of this study was to investigate whether public-aimed dietary recommendations for long-chain n-3 PUFA from oily fish or fish oil supplements are efficient in optimizing their status in red blood cells (RBCs) and platelets of healthy middle-aged subjects with low customary fish consumption. In a randomized, cross-over trial conducted over an 8-week period and separated by a 6-month washout period, 33 participants received an oily fish (salmon), providing 274 mg eicosapentaenoic acid (EPA) + 671 mg docosahexaenoic acid (DHA) per day, or a commercial fish oil supplement, providing 396 mg EPA + 250 mg DHA per day. Blood samples were collected before and after each intervention period, and RBCs and platelets were used for analysis of fatty acids. After 8 weeks, there were significant increases in EPA and DHA content in RBCs and platelets with both salmon and fish oil capsules. The increase in EPA in both RBCs and platelets was higher with capsules, whereas the increase in DHA in both RBCs and platelets was higher with salmon. In spite of the quantitative and qualitative differences between n-3 fatty acid profiles in salmon and the fish oil supplement, the overall incorporation of these fatty acids into RBCs and platelets did not differ in our short-term study (P > .05). The sum of EPA + DHA significantly increased in both compartments following dietary recommendations for oily fish and fish oil supplements intake in middle-aged healthy subjects with low baseline long-chain n-3 PUFA status, although targeted values with optimal cardioprotective effect of more than 8% were not achieved. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24655487/Long_chain_n_3_polyunsaturated_fatty_acid_dietary_recommendations_are_moderately_efficient_in_optimizing_their_status_in_healthy_middle_aged_subjects_with_low_fish_consumption:_a_cross_over_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00291-1 DB - PRIME DP - Unbound Medicine ER -