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Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet.
Nutr Res 2014; 34(3):258-67NR

Abstract

Lotus (Nelumbo Nucifera) root, a well-known medicinal plant in Asia, is reported to have various therapeutic benefits, including anti-diabetes, anti-hypertension, and anti-hyperlipidaemia. We hypothesized that the ethanol extract of lotus root (ELR) would exhibit an anti-adipogenic effect in human pre-adipocytes as well as anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Treatment with ELR in human pre-adipocytes resulted in inhibition of lipid accumulation and attenuated expression of adipogenic transcription factors such as peroxisome proliferator-activated receptor gamma and adipocyte marker genes, such as glucose transporter 4 and leptin. Administration of ELR resulted in a significant decrease in relative weights of adipose tissues in rats fed a high-fat diet. Consumption of a high-fat diet resulted in an increase in serum total cholesterol (TC) and triglyceride (TG) levels; however, administration of ELR resulted in a decrease in the levels of TC and TG. Administration of ELR resulted in a decrease in the level of serum leptin and insulin. Administration of ELR in rats fed a high-fat diet resulted in a decrease in hepatic thiobarbituric acid reactive substance content, elevated by a high-fat diet and an increase in superoxide dismutase activity and hepatic glutathione content. These results suggest that lotus root exerts anti-oxidant and anti-obesity effects and could be used as a functional and nutraceutical ingredient in combatting obesity-related diseases.

Authors+Show Affiliations

Department of Food and Nutrition, Inha University, 100 Inha-ro, Nam-gu, Incheon, 402-751, Republic of Korea.Department of Food and Nutrition, Inha University, 100 Inha-ro, Nam-gu, Incheon, 402-751, Republic of Korea.East-west Bone & Joint Disease Research Institute, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, Gangdong-gu, Seoul, 134-727, Republic of Korea.Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 143-701, Republic of Korea.Department of Food and Nutrition, Inha University, 100 Inha-ro, Nam-gu, Incheon, 402-751, Republic of Korea. Electronic address: kjchang@inha.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24655493

Citation

You, Jeong Soon, et al. "Ethanol Extract of Lotus (Nelumbo Nucifera) Root Exhibits an Anti-adipogenic Effect in Human Pre-adipocytes and Anti-obesity and Anti-oxidant Effects in Rats Fed a High-fat Diet." Nutrition Research (New York, N.Y.), vol. 34, no. 3, 2014, pp. 258-67.
You JS, Lee YJ, Kim KS, et al. Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Nutr Res. 2014;34(3):258-67.
You, J. S., Lee, Y. J., Kim, K. S., Kim, S. H., & Chang, K. J. (2014). Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Nutrition Research (New York, N.Y.), 34(3), pp. 258-67. doi:10.1016/j.nutres.2014.01.003.
You JS, et al. Ethanol Extract of Lotus (Nelumbo Nucifera) Root Exhibits an Anti-adipogenic Effect in Human Pre-adipocytes and Anti-obesity and Anti-oxidant Effects in Rats Fed a High-fat Diet. Nutr Res. 2014;34(3):258-67. PubMed PMID: 24655493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet. AU - You,Jeong Soon, AU - Lee,Yun Ju, AU - Kim,Kyoung Soo, AU - Kim,Sung Hoon, AU - Chang,Kyung Ja, Y1 - 2014/01/21/ PY - 2013/09/25/received PY - 2013/12/10/revised PY - 2014/01/14/accepted PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2014/12/15/medline KW - Adipocyte KW - Ani-oxidant KW - Anti-obesity KW - Lotus (Nelumbo Nucifera) root KW - Rat SP - 258 EP - 67 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 3 N2 - Lotus (Nelumbo Nucifera) root, a well-known medicinal plant in Asia, is reported to have various therapeutic benefits, including anti-diabetes, anti-hypertension, and anti-hyperlipidaemia. We hypothesized that the ethanol extract of lotus root (ELR) would exhibit an anti-adipogenic effect in human pre-adipocytes as well as anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Treatment with ELR in human pre-adipocytes resulted in inhibition of lipid accumulation and attenuated expression of adipogenic transcription factors such as peroxisome proliferator-activated receptor gamma and adipocyte marker genes, such as glucose transporter 4 and leptin. Administration of ELR resulted in a significant decrease in relative weights of adipose tissues in rats fed a high-fat diet. Consumption of a high-fat diet resulted in an increase in serum total cholesterol (TC) and triglyceride (TG) levels; however, administration of ELR resulted in a decrease in the levels of TC and TG. Administration of ELR resulted in a decrease in the level of serum leptin and insulin. Administration of ELR in rats fed a high-fat diet resulted in a decrease in hepatic thiobarbituric acid reactive substance content, elevated by a high-fat diet and an increase in superoxide dismutase activity and hepatic glutathione content. These results suggest that lotus root exerts anti-oxidant and anti-obesity effects and could be used as a functional and nutraceutical ingredient in combatting obesity-related diseases. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24655493/Ethanol_extract_of_lotus__Nelumbo_nucifera__root_exhibits_an_anti_adipogenic_effect_in_human_pre_adipocytes_and_anti_obesity_and_anti_oxidant_effects_in_rats_fed_a_high_fat_diet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(14)00016-5 DB - PRIME DP - Unbound Medicine ER -