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Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents.
Nutr Metab Cardiovasc Dis. 2014 Jul; 24(7):737-43.NM

Abstract

BACKGROUND AND AIMS

The triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease. We evaluated in a large sample of children and adolescents the association of TG/HDL-C ratio with early signs of morphological vascular changes and cardiometabolic risk factors including nonalcoholic fatty liver disease (NAFLD).

METHODS AND RESULTS

The study population, including 548 children (aged 6-16 years), of whom 157 were normal-weight, 118 overweight, and 273 obese, had anthropometric, laboratory, liver and carotid ultrasonography (carotid artery intima-media thickness-cIMT) data collected. Subjects were stratified into tertiles of TG/HDL-C. There was a progressive increase in body mass index (BMI), BMI-SD score (SDS), waist circumference, blood pressure (BP), liver enzymes, glucose, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein (hsCRP), and cIMT values across TG/HDL-C tertiles. The odds ratios for central obesity, insulin resistance, high hsCRP, NAFLD, metabolic syndrome, and elevated cIMT increased significantly with the increasing tertile of TG/HDL-C ratio, after adjustment for age, gender, pubertal status, and BMI-SDS. In a stepwise multivariate logistic regression analysis, increased cIMT was associated with high TG/HDL-C ratio [OR, 1.81 (95% CI, 1.08-3.04); P < 0.05], elevated BP [5.13 (95% CI, 1.03-15.08); P < 0.05], insulin resistance [2.16 (95% CI, 1.30-3.39); P < 0.01], and NAFLD [2.70 (95% CI, 1.62-4.56); P < 0.01].

CONCLUSION

TG/HDL-C ratio may help identify children and adolescents at high risk for structural vascular changes and metabolic derangement.

Authors+Show Affiliations

Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Italy.Department of Experimental Medicine, Sapienza University of Rome, Italy.Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Italy.Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Italy.Department of Radiological Sciences, Sapienza University of Rome, Italy.Department of Radiological Sciences, Sapienza University of Rome, Italy.Institute of Translational Pharmacology, National Research Council, Via del Fosso del Cavaliere 100, 00133 Rome, Italy. Electronic address: lucia.pacifico@uniroma1.it.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24656140

Citation

Pacifico, L, et al. "Association of Serum triglyceride-to-HDL Cholesterol Ratio With Carotid Artery Intima-media Thickness, Insulin Resistance and Nonalcoholic Fatty Liver Disease in Children and Adolescents." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 24, no. 7, 2014, pp. 737-43.
Pacifico L, Bonci E, Andreoli G, et al. Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents. Nutr Metab Cardiovasc Dis. 2014;24(7):737-43.
Pacifico, L., Bonci, E., Andreoli, G., Romaggioli, S., Di Miscio, R., Lombardo, C. V., & Chiesa, C. (2014). Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 24(7), 737-43. https://doi.org/10.1016/j.numecd.2014.01.010
Pacifico L, et al. Association of Serum triglyceride-to-HDL Cholesterol Ratio With Carotid Artery Intima-media Thickness, Insulin Resistance and Nonalcoholic Fatty Liver Disease in Children and Adolescents. Nutr Metab Cardiovasc Dis. 2014;24(7):737-43. PubMed PMID: 24656140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents. AU - Pacifico,L, AU - Bonci,E, AU - Andreoli,G, AU - Romaggioli,S, AU - Di Miscio,R, AU - Lombardo,C V, AU - Chiesa,C, Y1 - 2014/01/29/ PY - 2013/10/10/received PY - 2013/12/17/revised PY - 2014/01/07/accepted PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2015/1/31/medline KW - Carotid artery intima-media thickness KW - Children KW - Insulin resistance KW - Nonalcoholic fatty liver disease KW - Triglyceride-to-HDL cholesterol ratio SP - 737 EP - 43 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 24 IS - 7 N2 - BACKGROUND AND AIMS: The triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease. We evaluated in a large sample of children and adolescents the association of TG/HDL-C ratio with early signs of morphological vascular changes and cardiometabolic risk factors including nonalcoholic fatty liver disease (NAFLD). METHODS AND RESULTS: The study population, including 548 children (aged 6-16 years), of whom 157 were normal-weight, 118 overweight, and 273 obese, had anthropometric, laboratory, liver and carotid ultrasonography (carotid artery intima-media thickness-cIMT) data collected. Subjects were stratified into tertiles of TG/HDL-C. There was a progressive increase in body mass index (BMI), BMI-SD score (SDS), waist circumference, blood pressure (BP), liver enzymes, glucose, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein (hsCRP), and cIMT values across TG/HDL-C tertiles. The odds ratios for central obesity, insulin resistance, high hsCRP, NAFLD, metabolic syndrome, and elevated cIMT increased significantly with the increasing tertile of TG/HDL-C ratio, after adjustment for age, gender, pubertal status, and BMI-SDS. In a stepwise multivariate logistic regression analysis, increased cIMT was associated with high TG/HDL-C ratio [OR, 1.81 (95% CI, 1.08-3.04); P < 0.05], elevated BP [5.13 (95% CI, 1.03-15.08); P < 0.05], insulin resistance [2.16 (95% CI, 1.30-3.39); P < 0.01], and NAFLD [2.70 (95% CI, 1.62-4.56); P < 0.01]. CONCLUSION: TG/HDL-C ratio may help identify children and adolescents at high risk for structural vascular changes and metabolic derangement. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/24656140/Association_of_serum_triglyceride_to_HDL_cholesterol_ratio_with_carotid_artery_intima_media_thickness_insulin_resistance_and_nonalcoholic_fatty_liver_disease_in_children_and_adolescents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(14)00041-6 DB - PRIME DP - Unbound Medicine ER -