Tags

Type your tag names separated by a space and hit enter

Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice.
J Microbiol Immunol Infect. 2016 Feb; 49(1):91-6.JM

Abstract

BACKGROUND/PURPOSE

Interleukin-33 (IL-33) could play an important role in the pathogenesis of angiostrongylosis. However, the role of IL-33/ST2 pathway in this parasitic infection is uncertain.

METHODS

C57BL/six mice were each infected with 35 Angiostrongylus cantonensis larvae. One group of mice received an intraperitoneal injection of anti-ST2 monoclonal antibody (mAb; 50 μg) 3 days postinfection and subsequent booster shots of the same dose at 5-day intervals. Blood samples from each group were collected every week for assays.

RESULTS

The level of IL-5 significantly decreased in the mAb-treated group, and the infiltration of eosinophils in the meninges was also significantly reduced.

CONCLUSION

The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this parasitic infection.

Authors+Show Affiliations

School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan; Section of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.Department of Cosmetic Science, Vanung University, Zhongli City, Taoyuan, Taiwan.School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan.School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan. Electronic address: 059262@mail.fju.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24657070

Citation

Chuang, Chih-Cheng, et al. "Anti-ST2 Monoclonal Antibody Inhibits Eosinophil Infiltration in Angiostrongylus Cantonensis-infected Mice." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 49, no. 1, 2016, pp. 91-6.
Chuang CC, Chen CW, Huang YT, et al. Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice. J Microbiol Immunol Infect. 2016;49(1):91-6.
Chuang, C. C., Chen, C. W., Huang, Y. T., & Du, W. Y. (2016). Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 49(1), 91-6. https://doi.org/10.1016/j.jmii.2014.01.009
Chuang CC, et al. Anti-ST2 Monoclonal Antibody Inhibits Eosinophil Infiltration in Angiostrongylus Cantonensis-infected Mice. J Microbiol Immunol Infect. 2016;49(1):91-6. PubMed PMID: 24657070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice. AU - Chuang,Chih-Cheng, AU - Chen,Chi-Wu, AU - Huang,Yu-Tzu, AU - Du,Wen-Yuan, Y1 - 2014/03/21/ PY - 2013/11/15/received PY - 2014/01/22/revised PY - 2014/01/22/accepted PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2016/11/2/medline KW - Angiostrongylus cantonensis KW - Interleukin-33 KW - ST2 SP - 91 EP - 6 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 49 IS - 1 N2 - BACKGROUND/PURPOSE: Interleukin-33 (IL-33) could play an important role in the pathogenesis of angiostrongylosis. However, the role of IL-33/ST2 pathway in this parasitic infection is uncertain. METHODS: C57BL/six mice were each infected with 35 Angiostrongylus cantonensis larvae. One group of mice received an intraperitoneal injection of anti-ST2 monoclonal antibody (mAb; 50 μg) 3 days postinfection and subsequent booster shots of the same dose at 5-day intervals. Blood samples from each group were collected every week for assays. RESULTS: The level of IL-5 significantly decreased in the mAb-treated group, and the infiltration of eosinophils in the meninges was also significantly reduced. CONCLUSION: The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this parasitic infection. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/24657070/Anti_ST2_monoclonal_antibody_inhibits_eosinophil_infiltration_in_Angiostrongylus_cantonensis_infected_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1684-1182(14)00012-7 DB - PRIME DP - Unbound Medicine ER -