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Changes in lipid measures and incident coronary heart disease: Tehran Lipid & Glucose Study.
Clin Biochem. 2014 Sep; 47(13-14):1239-44.CB

Abstract

BACKGROUND

Data on the impact of changes in lipid measures on subsequent coronary heart disease (CHD) outcomes are not consistent.

METHODS

Study was conducted in 4459 adults, aged ≥30 years, free of cardiovascular disease at baseline who attended two consecutive examinations first in 1999-2001 and second in 2001-2003, and were followed up until March 31, 2010. Multivariate Cox proportional hazard regression adjusted for baseline lipid measures and other risk factors was calculated for a 1 standard deviation (SD) change in total cholesterol (TC), log-transformed triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) (calculated using modified Friedewald formula), non-HDL-C, TC/HDL-C and log-transformed TG/HDL-C. Effect of change in dyslipidemia (TC ≥6.21 mmol/L or TG ≥2.26 mmol/L or HDL-C <1.03 mmol/L or non-HDL-C ≥4.91 mmol/L) on incident CHD was examined, considering those with no dyslipidemia at baseline and follow-up as the reference group.

RESULTS

During a mean follow-up of 9.5 years, 303 cases of CHD occurred. A 1-SD increase in TC, TG, non-HDL-C, TC/HDL-C and TG/HDL-C was associated with 14, 20, 19, 16 and 14% increase in risk of CHD event, respectively (all p values <0.05); the corresponding risk for LDL-C was [1.12 (0.99-1.27), P=0.07]. Participants with maintained dyslipidemia during follow-up had a significant risk for incident CHD [HR: 1.67(1.21-2.49)] compared to those with no dyslipidemia at baseline or follow-up.

CONCLUSION

Changes in TC, TG, and non-HDL-C, TC/HDL-C, TG/HDL-C were independent predictors of CHD events. Furthermore, maintained dyslipidemia was a strong predictor for CHD events.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: fzhadaegh@endocrine.ac.ir.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24657509

Citation

Nejat, Amirahmad, et al. "Changes in Lipid Measures and Incident Coronary Heart Disease: Tehran Lipid & Glucose Study." Clinical Biochemistry, vol. 47, no. 13-14, 2014, pp. 1239-44.
Nejat A, Mirbolouk M, Mohebi R, et al. Changes in lipid measures and incident coronary heart disease: Tehran Lipid & Glucose Study. Clin Biochem. 2014;47(13-14):1239-44.
Nejat, A., Mirbolouk, M., Mohebi, R., Hasheminia, M., Tohidi, M., Saadat, N., Azizi, F., & Hadaegh, F. (2014). Changes in lipid measures and incident coronary heart disease: Tehran Lipid & Glucose Study. Clinical Biochemistry, 47(13-14), 1239-44. https://doi.org/10.1016/j.clinbiochem.2014.03.004
Nejat A, et al. Changes in Lipid Measures and Incident Coronary Heart Disease: Tehran Lipid & Glucose Study. Clin Biochem. 2014;47(13-14):1239-44. PubMed PMID: 24657509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in lipid measures and incident coronary heart disease: Tehran Lipid & Glucose Study. AU - Nejat,Amirahmad, AU - Mirbolouk,Mohammadhassan, AU - Mohebi,Reza, AU - Hasheminia,Mitra, AU - Tohidi,Maryam, AU - Saadat,Navid, AU - Azizi,Fereidoun, AU - Hadaegh,Farzad, Y1 - 2014/03/21/ PY - 2013/09/09/received PY - 2014/03/11/revised PY - 2014/03/13/accepted PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2015/5/13/medline KW - Coronary heart disease KW - Dyslipidemia KW - Lipid change SP - 1239 EP - 44 JF - Clinical biochemistry JO - Clin. Biochem. VL - 47 IS - 13-14 N2 - BACKGROUND: Data on the impact of changes in lipid measures on subsequent coronary heart disease (CHD) outcomes are not consistent. METHODS: Study was conducted in 4459 adults, aged ≥30 years, free of cardiovascular disease at baseline who attended two consecutive examinations first in 1999-2001 and second in 2001-2003, and were followed up until March 31, 2010. Multivariate Cox proportional hazard regression adjusted for baseline lipid measures and other risk factors was calculated for a 1 standard deviation (SD) change in total cholesterol (TC), log-transformed triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) (calculated using modified Friedewald formula), non-HDL-C, TC/HDL-C and log-transformed TG/HDL-C. Effect of change in dyslipidemia (TC ≥6.21 mmol/L or TG ≥2.26 mmol/L or HDL-C <1.03 mmol/L or non-HDL-C ≥4.91 mmol/L) on incident CHD was examined, considering those with no dyslipidemia at baseline and follow-up as the reference group. RESULTS: During a mean follow-up of 9.5 years, 303 cases of CHD occurred. A 1-SD increase in TC, TG, non-HDL-C, TC/HDL-C and TG/HDL-C was associated with 14, 20, 19, 16 and 14% increase in risk of CHD event, respectively (all p values <0.05); the corresponding risk for LDL-C was [1.12 (0.99-1.27), P=0.07]. Participants with maintained dyslipidemia during follow-up had a significant risk for incident CHD [HR: 1.67(1.21-2.49)] compared to those with no dyslipidemia at baseline or follow-up. CONCLUSION: Changes in TC, TG, and non-HDL-C, TC/HDL-C, TG/HDL-C were independent predictors of CHD events. Furthermore, maintained dyslipidemia was a strong predictor for CHD events. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/24657509/Changes_in_lipid_measures_and_incident_coronary_heart_disease:_Tehran_Lipid_&_Glucose_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(14)00117-9 DB - PRIME DP - Unbound Medicine ER -