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Trypanocidal action of tea tree oil (Melaleuca alternifolia) against Trypanosoma evansi in vitro and in vivo used mice as experimental model.
Exp Parasitol. 2014 Jun; 141:21-7.EP

Abstract

This study aimed to evaluate the Trypanosoma evansi susceptibility to tea tree oil (TTO - Melaleuca alternifolia) and tea tree oil nanocapsules (TTO nanocapsules) in vitro and in vivo tests. In vitro, we observed a mortality curve of trypomastigotes proportional to dose, i.e., the TTO and TTO nanocapsules have trypanocidal effect. Treatment with TTO in vivo was assessed in experiments (I and II). For Experiment I, T. evansi infected mice were treated with TTO and/or combinations of essential oil with chemotherapy (diminazene aceturate - D.A.). Treatment with TTO at a dose of 1mLkg(-1) was able to extend animal longevity, but had no curative efficacy. However, when TTO was combined with D.A. a disease curative efficacy of 100% for disease was observed, a much better result than the D.A. treatment (33.3%). In Experiment II, T. evansi infected mice were treated with TTO nanocapsules with doses of 0.3, 0.6 and 0.9mLkg(-1). Animals treated with 0.9mLkg(-1) showed higher longevity however without curative effect. Active compounds present in natural products, such as M. alternifolia, may potentiate the treatment of trypanosomosis when associated with other trypanocidal drugs.

Authors+Show Affiliations

Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil; Laboratory of Microbiology, Centro Universitário Franciscano, Santa Maria, RS, Brazil.Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC, Brazil. Electronic address: aleksandro_ss@yahoo.com.br.Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.Laboratory of Microbiology, Centro Universitário Franciscano, Santa Maria, RS, Brazil; Laboratory of Nanotechnology, Centro Universitário Franciscano, Santa Maria, RS, Brazil.Laboratory of Microbiology, Centro Universitário Franciscano, Santa Maria, RS, Brazil.Laboratory of Nanotechnology, Centro Universitário Franciscano, Santa Maria, RS, Brazil.Laboratory of Nanotechnology, Centro Universitário Franciscano, Santa Maria, RS, Brazil.Department of Animal Production, Universidade do Estado de Santa Catarina (UDESC), Lages, SC, Brazil.Department of Animal Production, Universidade do Estado de Santa Catarina (UDESC), Lages, SC, Brazil.Laboratory of Phytochemistry, UFSM, Santa Maria, RS, Brazil.Laboratory of Phytochemistry, UFSM, Santa Maria, RS, Brazil.Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil. Electronic address: sgmonteiro@uol.com.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24657576

Citation

Baldissera, Matheus D., et al. "Trypanocidal Action of Tea Tree Oil (Melaleuca Alternifolia) Against Trypanosoma Evansi in Vitro and in Vivo Used Mice as Experimental Model." Experimental Parasitology, vol. 141, 2014, pp. 21-7.
Baldissera MD, Da Silva AS, Oliveira CB, et al. Trypanocidal action of tea tree oil (Melaleuca alternifolia) against Trypanosoma evansi in vitro and in vivo used mice as experimental model. Exp Parasitol. 2014;141:21-7.
Baldissera, M. D., Da Silva, A. S., Oliveira, C. B., Santos, R. C., Vaucher, R. A., Raffin, R. P., Gomes, P., Dambros, M. G., Miletti, L. C., Boligon, A. A., Athayde, M. L., & Monteiro, S. G. (2014). Trypanocidal action of tea tree oil (Melaleuca alternifolia) against Trypanosoma evansi in vitro and in vivo used mice as experimental model. Experimental Parasitology, 141, 21-7. https://doi.org/10.1016/j.exppara.2014.03.007
Baldissera MD, et al. Trypanocidal Action of Tea Tree Oil (Melaleuca Alternifolia) Against Trypanosoma Evansi in Vitro and in Vivo Used Mice as Experimental Model. Exp Parasitol. 2014;141:21-7. PubMed PMID: 24657576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trypanocidal action of tea tree oil (Melaleuca alternifolia) against Trypanosoma evansi in vitro and in vivo used mice as experimental model. AU - Baldissera,Matheus D, AU - Da Silva,Aleksandro S, AU - Oliveira,Camila B, AU - Santos,Roberto C V, AU - Vaucher,Rodrigo A, AU - Raffin,Renata P, AU - Gomes,Patrícia, AU - Dambros,Maria G C, AU - Miletti,Luiz C, AU - Boligon,Aline A, AU - Athayde,Margareth L, AU - Monteiro,Silvia G, Y1 - 2014/03/19/ PY - 2013/11/14/received PY - 2014/02/16/revised PY - 2014/03/04/accepted PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2014/6/11/medline KW - TTO KW - Trypanocidal effect KW - Trypanosoma evansi SP - 21 EP - 7 JF - Experimental parasitology JO - Exp Parasitol VL - 141 N2 - This study aimed to evaluate the Trypanosoma evansi susceptibility to tea tree oil (TTO - Melaleuca alternifolia) and tea tree oil nanocapsules (TTO nanocapsules) in vitro and in vivo tests. In vitro, we observed a mortality curve of trypomastigotes proportional to dose, i.e., the TTO and TTO nanocapsules have trypanocidal effect. Treatment with TTO in vivo was assessed in experiments (I and II). For Experiment I, T. evansi infected mice were treated with TTO and/or combinations of essential oil with chemotherapy (diminazene aceturate - D.A.). Treatment with TTO at a dose of 1mLkg(-1) was able to extend animal longevity, but had no curative efficacy. However, when TTO was combined with D.A. a disease curative efficacy of 100% for disease was observed, a much better result than the D.A. treatment (33.3%). In Experiment II, T. evansi infected mice were treated with TTO nanocapsules with doses of 0.3, 0.6 and 0.9mLkg(-1). Animals treated with 0.9mLkg(-1) showed higher longevity however without curative effect. Active compounds present in natural products, such as M. alternifolia, may potentiate the treatment of trypanosomosis when associated with other trypanocidal drugs. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/24657576/Trypanocidal_action_of_tea_tree_oil__Melaleuca_alternifolia__against_Trypanosoma_evansi_in_vitro_and_in_vivo_used_mice_as_experimental_model_ DB - PRIME DP - Unbound Medicine ER -