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Depression and chronic kidney disease: A review for clinicians.
Aust N Z J Psychiatry. 2014 Jun; 48(6):530-41.AN

Abstract

OBJECTIVE

To review the recent academic literature surrounding the prevalence, aetiopathology, associations and management of depression in chronic kidney disease (CKD), in order to provide a practical and up-to-date resource for clinicians.

METHODS

We conducted electronic searches of the following databases: MEDLINE, EMBASE and PsycINFO. The main search terms were: depression, mood disorders, depressive disorder, mental illness, in combination with kidney disease, renal insufficiency, dialysis, kidney failure. Separate searches were conducted regarding antidepressant use in CKD.

RESULTS

A number of recent, large and well-conducted studies have confirmed markedly raised rates of depression amongst those with CKD, with meta-analysis suggesting the prevalence of interview-defined depression to be approximately 20%. The interactions between depression and CKD are complex, bidirectional and multifactorial. Depression in CKD has been shown to be associated with multiple poor outcomes, including increased mortality and hospitalisation rates, as well as poorer treatment compliance and quality of life. Clinical evaluation of depression in patients with CKD can be challenging; however, once a diagnosis is made, a range of treatment modalities can be considered.

CONCLUSIONS

Depression is common in CKD and is associated with a significant risk of adverse outcomes. Given the importance of this issue, there is now an urgent need for well-conducted randomised trials of interventions for depression in CKD in order to provide information on the safety and efficacy of treatments.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Bautovich A
School of Psychiatry, University of New South Wales, Sydney, Australia NSW Institute of Psychiatry, Westmead, Australia St George Hospital, Kogarah, Australia a.bautovich@unsw.edu.au.
Katz I
St George Hospital, Kogarah, Australia Faculty of Medicine, University of New South Wales, Sydney, Australia.
Smith M
School of Psychiatry, University of New South Wales, Sydney, Australia Prince of Wales Hospital, Randwick, Australia.
Loo CK
School of Psychiatry, University of New South Wales, Sydney, Australia St George Hospital, Kogarah, Australia Black Dog Institute, Sydney, Australia.
Harvey SB
School of Psychiatry, University of New South Wales, Sydney, Australia St George Hospital, Kogarah, Australia Black Dog Institute, Sydney, Australia.

MeSH

DepressionHumansRenal Insufficiency, Chronic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24658294

Citation

Bautovich, Alison, et al. "Depression and Chronic Kidney Disease: a Review for Clinicians." The Australian and New Zealand Journal of Psychiatry, vol. 48, no. 6, 2014, pp. 530-41.
Bautovich A, Katz I, Smith M, et al. Depression and chronic kidney disease: A review for clinicians. Aust N Z J Psychiatry. 2014;48(6):530-41.
Bautovich, A., Katz, I., Smith, M., Loo, C. K., & Harvey, S. B. (2014). Depression and chronic kidney disease: A review for clinicians. The Australian and New Zealand Journal of Psychiatry, 48(6), 530-41. https://doi.org/10.1177/0004867414528589
Bautovich A, et al. Depression and Chronic Kidney Disease: a Review for Clinicians. Aust N Z J Psychiatry. 2014;48(6):530-41. PubMed PMID: 24658294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression and chronic kidney disease: A review for clinicians. AU - Bautovich,Alison, AU - Katz,Ivor, AU - Smith,Michelle, AU - Loo,Colleen K, AU - Harvey,Samuel B, Y1 - 2014/03/21/ PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2016/4/9/medline KW - Antidepressive agents KW - depression KW - dialysis KW - kidney disease KW - mental illness KW - renal failure SP - 530 EP - 41 JF - The Australian and New Zealand journal of psychiatry JO - Aust N Z J Psychiatry VL - 48 IS - 6 N2 - OBJECTIVE: To review the recent academic literature surrounding the prevalence, aetiopathology, associations and management of depression in chronic kidney disease (CKD), in order to provide a practical and up-to-date resource for clinicians. METHODS: We conducted electronic searches of the following databases: MEDLINE, EMBASE and PsycINFO. The main search terms were: depression, mood disorders, depressive disorder, mental illness, in combination with kidney disease, renal insufficiency, dialysis, kidney failure. Separate searches were conducted regarding antidepressant use in CKD. RESULTS: A number of recent, large and well-conducted studies have confirmed markedly raised rates of depression amongst those with CKD, with meta-analysis suggesting the prevalence of interview-defined depression to be approximately 20%. The interactions between depression and CKD are complex, bidirectional and multifactorial. Depression in CKD has been shown to be associated with multiple poor outcomes, including increased mortality and hospitalisation rates, as well as poorer treatment compliance and quality of life. Clinical evaluation of depression in patients with CKD can be challenging; however, once a diagnosis is made, a range of treatment modalities can be considered. CONCLUSIONS: Depression is common in CKD and is associated with a significant risk of adverse outcomes. Given the importance of this issue, there is now an urgent need for well-conducted randomised trials of interventions for depression in CKD in order to provide information on the safety and efficacy of treatments. SN - 1440-1614 UR - https://www.unboundmedicine.com/medline/citation/24658294/Depression_and_chronic_kidney_disease:_A_review_for_clinicians_ DB - PRIME DP - Unbound Medicine ER -