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The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China.
PLoS One. 2014; 9(3):e92700.Plos

Abstract

BACKGROUND

Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS is a fulminant, infectious disease that occurs worldwide and is endemic in all 31 provinces of China. Since the first HFRS case in Hubei Province was reported in 1957, the disease has spread across the province and Hubei has become one of the seriously affected areas in China with the greatest number of reported HFRS cases in the 1980's. However, the epidemic characteristics of HFRS in Hubei are still not entirely clear and long-term, systematic investigations of this epidemic area have been very limited.

METHODS

The spatiotemporal distribution of HFRS was investigated using data spanning the years 1980 to 2009. The annual HFRS incidence, fatality rate and seasonal incidence between 1980 and 2009 were calculated and plotted. GIS-based spatial analyses were conducted to detect the spatial distribution and seasonal pattern of HFRS. A spatial statistical analysis, using Kulldorff's spatial scan statistic, was performed to identify clustering of HFRS.

RESULTS

A total of 104,467 HFRS cases were reported in Hubei Province between 1980 and 2009. Incidence of and mortality due to HFRS declined after the outbreak in 1980s and HFRS cases have been sporadic in recent years. The locations and scale of disease clusters have changed during the three decades. The seasonal epidemic pattern of HFRS was characterized by the shift from the unimodal type (autumn/winter peak) to the bimodal type.

CONCLUSIONS

Socioeconomic development has great influence on the transmission of hantaviruses to humans and new epidemic characteristics have emerged in Hubei Province. It is necessary to reinforce preventative measures against HFRS according to the newly-presented seasonal variation and to intensify these efforts especially in the urban areas of Hubei Province.

Authors+Show Affiliations

State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.Tianjin Institute of Surveying and Mapping, Tianjin, PR China.Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, PR China.Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.Institute of Military Medical Sciences, Nanjing Command, Nanjing, PR China.State Key Laboratory of Information Engineering in Survey, Mapping and Remote Sensing, Wuhan University, Wuhan, Hubei, PR China.State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan, Hubei, PR China.

Pub Type(s)

Historical Article
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24658382

Citation

Zhang, Yi-Hui, et al. "The Epidemic Characteristics and Changing Trend of Hemorrhagic Fever With Renal Syndrome in Hubei Province, China." PloS One, vol. 9, no. 3, 2014, pp. e92700.
Zhang YH, Ge L, Liu L, et al. The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. PLoS ONE. 2014;9(3):e92700.
Zhang, Y. H., Ge, L., Liu, L., Huo, X. X., Xiong, H. R., Liu, Y. Y., Liu, D. Y., Luo, F., Li, J. L., Ling, J. X., Chen, W., Liu, J., Hou, W., Zhang, Y., Fan, H., & Yang, Z. Q. (2014). The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. PloS One, 9(3), e92700. https://doi.org/10.1371/journal.pone.0092700
Zhang YH, et al. The Epidemic Characteristics and Changing Trend of Hemorrhagic Fever With Renal Syndrome in Hubei Province, China. PLoS ONE. 2014;9(3):e92700. PubMed PMID: 24658382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. AU - Zhang,Yi-Hui, AU - Ge,Liang, AU - Liu,Li, AU - Huo,Xi-Xiang, AU - Xiong,Hai-Rong, AU - Liu,Yuan-Yuan, AU - Liu,Dong-Ying, AU - Luo,Fan, AU - Li,Jin-Lin, AU - Ling,Jia-Xin, AU - Chen,Wen, AU - Liu,Jing, AU - Hou,Wei, AU - Zhang,Yun, AU - Fan,Hong, AU - Yang,Zhan-Qiu, Y1 - 2014/03/21/ PY - 2013/10/28/received PY - 2014/02/24/accepted PY - 2014/3/25/entrez PY - 2014/3/25/pubmed PY - 2014/11/19/medline SP - e92700 EP - e92700 JF - PloS one JO - PLoS ONE VL - 9 IS - 3 N2 - BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS is a fulminant, infectious disease that occurs worldwide and is endemic in all 31 provinces of China. Since the first HFRS case in Hubei Province was reported in 1957, the disease has spread across the province and Hubei has become one of the seriously affected areas in China with the greatest number of reported HFRS cases in the 1980's. However, the epidemic characteristics of HFRS in Hubei are still not entirely clear and long-term, systematic investigations of this epidemic area have been very limited. METHODS: The spatiotemporal distribution of HFRS was investigated using data spanning the years 1980 to 2009. The annual HFRS incidence, fatality rate and seasonal incidence between 1980 and 2009 were calculated and plotted. GIS-based spatial analyses were conducted to detect the spatial distribution and seasonal pattern of HFRS. A spatial statistical analysis, using Kulldorff's spatial scan statistic, was performed to identify clustering of HFRS. RESULTS: A total of 104,467 HFRS cases were reported in Hubei Province between 1980 and 2009. Incidence of and mortality due to HFRS declined after the outbreak in 1980s and HFRS cases have been sporadic in recent years. The locations and scale of disease clusters have changed during the three decades. The seasonal epidemic pattern of HFRS was characterized by the shift from the unimodal type (autumn/winter peak) to the bimodal type. CONCLUSIONS: Socioeconomic development has great influence on the transmission of hantaviruses to humans and new epidemic characteristics have emerged in Hubei Province. It is necessary to reinforce preventative measures against HFRS according to the newly-presented seasonal variation and to intensify these efforts especially in the urban areas of Hubei Province. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24658382/The_epidemic_characteristics_and_changing_trend_of_hemorrhagic_fever_with_renal_syndrome_in_Hubei_Province_China_ L2 - http://dx.plos.org/10.1371/journal.pone.0092700 DB - PRIME DP - Unbound Medicine ER -